期刊
ORGANIC LETTERS
卷 17, 期 6, 页码 1433-1436出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00279
关键词
-
资金
- National Science Foundation [CHE-1145236]
- National Institute of Health [GM033049]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1360634] Funding Source: National Science Foundation
The phosphine-catalyzed synthesis of 1,2-dihydropyridines via an alkyne isomerization/electrocyclization sequence is described. Propargylidenecarbamate substrates were prepared following a one-pot procedure between a terminal alkyne, a benzonitrile, and a chloroformate in the presence of trimethylaluminum. This methodology gives access to a diverse set of 2,6-disubstituted 1,2-dihydropyridines in high yield. The products can be easily converted into substituted piperidines or pyridines, and this methodology was applied to the synthesis of indolizidines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据