Article
Medicine, Research & Experimental
Weiquan Zeng, Xiuli Zhang, Yao Lu, Ying Wen, Qiurong Xie, Xuan Yang, Shuyu He, Zhi Guo, Jiapeng Li, Aling Shen, Jun Peng
Summary: This study investigates the effect of neferine on hypertensive vascular remodeling and its underlying mechanisms. The results demonstrate that neferine can effectively reduce blood pressure, pulse wave velocity, and abdominal aortic thickening in hypertensive rats. It also suppresses the abnormal activation of PI3K/AKT and TGF-beta/Smad2/3 signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Bing Xiao, Fan Liu, Ye-Hui Jin, Ya-Qiong Jin, Li Wang, Jing-Chao Lu, Xiu-Chun Yang
Summary: In SHRs, RSD can effectively lower blood pressure, alleviate hypertension-induced left ventricular hypertrophy, and improve cardiac function by suppressing the Raf/MEK/ERK signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Toxicology
Lidieli P. Tardelli, Francine Duchatsch, Naiara A. Herrera, Carlos Alberto Vicentini, Katashi Okoshi, Sandra L. Amaral
Summary: The study found that the effects of dexamethasone on normotensive and hypertensive rats were different. For hypertensive rats (SHR), dexamethasone did not change blood pressure or autonomic balance to the heart, but reduced certain cardiac parameters. However, in normotensive rats (Wistar), dexamethasone led to changes in blood pressure and autonomic regulation, as well as arterial stiffness and cardiac structure.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Leticia Estevam Engel, Francilene Lima Agostinho de Souza, Ines Cristina Giometti, Katashi Okoshi, Thaoan Bruno Mariano, Natalia Zamberlan Ferreira, Dyovana Gomes Pinheiro, Rafael Stuani Floriano, Andreo Fernando Aguiar, Antonio Carlos Cicogna, Ivan Jose Vechetti, Francis Lopes Pacagnelli
Summary: This study evaluated the effects of high-intensity interval training on cardiac structural and functional characteristics in hypertensive rats. The results showed that high-intensity interval training decreased blood pressure, improved cardiac function, and reversed alterations in gene encoding.
Article
Biochemistry & Molecular Biology
Xiaoqin Zhang, Pingcui Xu, Bingfeng Lin, Xuehui Deng, Jiazhen Zhu, Xinyi Chen, Shuang Liu, Rui Li, Nani Wang, Liping Chen
Summary: Chimonanthus salicifolius (CS), an effective tea for preventing and treating hypertension in China, has been found to protect against vascular remodeling by suppressing endoplasmic reticulum stress-related apoptosis. It also improves dyslipidemia associated with hypertension.
Article
Biochemistry & Molecular Biology
Sayeman Islam Niloy, Yue Shen, Lirong Guo, Stephen T. O'Rourke, Chengwen Sun
Summary: This study reveals that dysfunction of BKCa channels in vascular smooth muscle cells (VSMCs) is related to abnormal proliferation and morphological changes in hypertension, possibly due to decoupling of IP3R-BKCa. Genetic disruption of IP3R-BKCa coupling increases VSMC proliferation, while infusion of the BKCa opener NS1619 attenuates vascular hypertrophy in hypertensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nan Wu, Fen Zheng, Na Li, Ying Han, Xiao-Qing Xiong, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ye-Bo Zhou
Summary: The study revealed that RND3 plays critical roles in attenuating superoxide production, vascular smooth muscle cells migration and proliferation, and vascular remodeling in hypertension by inhibiting ROCK1-NOX1/2 and mitochondria superoxide signaling.
Article
Geriatrics & Gerontology
Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming Ji
Summary: Vascular remodeling is an initial step in the development of hypertension, and limb remote ischemic conditioning (LRIC) has shown promising effects on ameliorating blood pressure and vascular remodeling through inflammation regulation in animal models and patients with prehypertension and early-stage hypertension. The study suggests that long-term LRIC treatment may be a potential preventive approach for individuals with elevated blood pressure or prehypertension.
Article
Biochemistry & Molecular Biology
Sijo Joseph Thandapilly, Xavier Louis, Wilhelmina Kalt, Pema Raj, Jillian L. Stobart, Basma M. Aloud, Melinda Vinqvist-Tymchuk, Liping Yu, Jacques Kaminski, Norbert Latruffe, Christopher M. Anderson, Hope D. Anderson, Thomas Netticadan
Summary: This study found that blueberry polyphenolic extract can reduce vascular remodeling in hypertensive rats, providing cardiovascular protection.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Article
Computer Science, Interdisciplinary Applications
Xiaowen Zuo, Zhike Xu, Huaping Jia, Yang Mu, Mingming Zhang, Manli Yuan, Chengwei Wu
Summary: This study examined the flow field of the left ventricle in patients with hypertensive myocardial hypertrophy and found that the characteristics of the flow field in these patients were consistent with clinical data. It confirmed that myocardial hypertrophy has a significant impact on left ventricular blood flow.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Tingjun Wang, Xiaoqi Cai, Jinze Li, Liangdi Xie
Summary: This study investigated global changes in protein profile in the myocardium of spontaneously hypertensive rats using liquid chromatography coupled with tandem mass spectrometry. There were 369 differentially expressed proteins in the myocardium between spontaneously hypertensive rats and normotensive rats. These differentially expressed proteins were involved in important pathways related to biological processes, molecular functions, and cellular components, and the drug metabolism-cytochrome P450 pathway was the most significantly enriched. FYN proto-oncogene, Src family tyrosine kinase had the highest number of interactions with other proteins. These differentially expressed proteins may serve as targets for further study of hypertension-related left ventricular hypertrophy.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Maria Cecilia Teles, Alexandre Martins Oliveira Portes, Bianca Iara Campos Coelho, Leticia Teresinha Resende, Mauro Cesar Isoldi
Summary: Systemic arterial hypertension is a clinical condition characterized by high and sustained levels of blood pressure. Research on spontaneously hypertensive animals has provided insights into the physiological changes that affect the heart in hypertension. Aerobic exercise has shown to improve cardiac function and reduce inflammation and oxidative stress in the heart, although the precise mechanisms are not fully understood. This review provides an overview of the pathological changes in the heart of spontaneously hypertensive animals and the modulatory effects of aerobic exercise.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Tomasz K. Bednarski, Monika K. Duda, Pawel Dobrzyn
Summary: Disturbances in cardiac lipid metabolism are associated with the development of cardiac hypertrophy and heart failure in spontaneously hypertensive rats. Triglyceride accumulation in cardiomyocytes, due to lower rates of lipolysis and beta-oxidation, is linked to the development of left ventricular hypertrophy and myocardial dysfunction in SHR.
Article
Sport Sciences
Kelly M. Stanton, Laura Wylie, Irina Kotchetkova, Amy Coy, Gerard Carroll, Andre La Gerche, David S. Celermajer
Summary: Increasing exercise intensity is associated with cardiac remodeling in healthy young soldiers, with chamber dimensions increasing in a dose-dependent manner. However, fitness did not increase further after high-intensity exercise.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Primary Health Care
B. Rodriguez-Borlado Diaz, D. Sanz-Rosa, B. Sanz Pozo, J. L. Llisterri Caro, M. Herrero Barbero
Summary: This study evaluated pain, quality of life, and psychological state in patients with gonalgia due to gonarthrosis. The results showed that patients with arthrosis experienced moderate pain and had limitations in mobility, personal care, and daily activities, negatively impacting their quality of life. They also exhibited a higher prevalence of psychopathology. Therefore, the development of self-care and treatment strategies for this group is crucial for improving their overall quality of life.
MEDICINA DE FAMILIA-SEMERGEN
(2022)
Article
Critical Care Medicine
Henrique Doria de Vasconcellos, Karen Ruggeri Saad, Paulo Fernandes Saad, Denise Aya Otsuki, Luisa A. Ciuffo, Laeben Lester, Marcia Kiyomi Koike, Anderson da Costa Armstrong, Joao A. C. Lima, Edna Frasson de Souza Montero
Summary: Speckle tracking echocardiography accurately evaluates myocardial deformation in a hemorrhagic shock swine model, showing a significant decrease in global longitudinal strain during severe hemorrhagic shock.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ernesto Martinez-Martinez, Victoria Cachofeiro
Article
Biochemistry & Molecular Biology
Luis Felipe Rodrigues, Bruno Rocha Avila Pelozin, Natan Daniel da Silva Junior, Ursula Paula Reno Soci, Everton Crivoi do Carmo, Gloria de Fatima Alves da Mota, Victoria Cachofeiro, Vicente Lahera, Edilamar Menezes Oliveira, Tiago Fernandes
Summary: Aerobic exercise training promotes angiogenesis through the miRNA-27a/b-ACE1/Ang II/VEGF axis and improves the redox balance in skeletal muscles. The involvement of the renin-angiotensin system suggests its important role in exercise training-induced vascular growth. miRNAs and RAS components are promising potential targets to modulate angiogenesis for combating vascular diseases, as well as potential biomarkers to monitor training interventions and physical performance.
Article
Biochemistry & Molecular Biology
Hiviny A. Raquel, Louisi A. Manica, Alexandre Ceroni, Lisete C. Michelini
Summary: Previous studies have shown that removing baroreceptors and chemoreceptors impairs central autonomic circuitry and worsens cardiovascular function in rats. Exercise training can improve autonomic control of circulation. In rats without baroreceptors, exercise training can improve cardiovascular control but does not reduce blood pressure levels.
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Article
Medicine, Research & Experimental
Camila S. Balbino-Silva, Gisele K. Couto, Caroline A. Lino, Tabatha de Oliveira-Silva, Guilherme Lunardon, Zhan-Peng Huang, William T. Festuccia, Maria Luiza Barreto-Chaves, Da-Zhi Wang, Luciana V. Rossoni, Gabriela P. Diniz
Summary: This study found that miRNA-22 plays an important role in vascular reactivity and obesity-induced PVAT dysfunction, and its deletion attenuates the impact of obesity on the anticontractile effect of PVAT.
Article
Medicine, Research & Experimental
Milene T. Fontes, Daniel F. Arruda-Junior, Danubia Silva dos Santos, Joao Carlos Ribeiro-Silva, Edinei L. Anto, Paulo F. J. Tucci, Luciana V. Rossoni, Adriana C. C. Girardi
Summary: This study tested the effects of DPP4 inhibitor vildagliptin on aortic hyperreactivity in male HF rats. The results showed that DPP4i mitigated the hypercontractility of HF aortas and enhanced NO bioavailability, suggesting a potential protective effect on the arteries.
Article
Physiology
Vanessa B. Candido, Sany M. Perego, Alexandre Ceroni, Martin Metzger, Alison Colquhoun, Lisete C. Michelini
Summary: Chronic hypertension is accompanied by blood-brain barrier (BBB) leakage and autonomic dysfunction. The mechanism determining increased BBB permeability within autonomic areas is unclear. Exercise training can restore BBB permeability and autonomic control of the circulation. This study aimed to clarify the mechanism(s) governing hypertension- and exercise-induced BBB permeability. The results showed that transcytosis, not the paracellular transport, is the primary mechanism underlying both hypertension- and exercise-induced BBB permeability changes within autonomic areas.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Hiviny de Ataides Raquel, Sany M. Perego, Gustavo S. Masson, Leonardo Jensen, Alison Colquhoun, Lisete C. Michelini
Article
Urology & Nephrology
Victor Duque-Santana, Ana Diaz-Gavela, Manuel Recio, Luis Leonardo Guerrero, Marina Pena, Sofia Sanchez, Fernando Lopez-Campos, Israel J. Thuissard, Cristina Andreu, David Sanz-Rosa, Verane Achard, Alfonso Gomez-Iturriaga, Yolanda Molina, Elia Del Cerro Penalver, Felipe Counago
Summary: This study analyzes the long-term survival outcomes of localized prostate adenocarcinoma patients treated with radiotherapy and androgen deprivation therapy. The results show that multiparametric magnetic resonance imaging is a key tool in diagnosing and establishing risk groups for these patients, leading to optimized treatment.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Surgery
Marcia Kiyomi Koike, Denise Frediani Barbeiro, Heraldo Possolo de Souza, Marcel Cerqueira Cesar Machado
Summary: This study evaluated the local and systemic effects of 24-hour fasting in liver ischemia and reperfusion injury. The results showed that fasting did not provide protection but instead may be detrimental to the liver in the context of ischemia/reperfusion damage. Therefore, long fasting before liver surgery should be avoided in clinical practice.
ACTA CIRURGICA BRASILEIRA
(2023)
Article
Surgery
Rafael Izar Domingues da Costa, Joao Marcos da Silva Fischer, Roberto Rasslan, Marcia Kiyomi Koike, Edvaldo Massazo Utiyama, Edna Frasson de Souza Montero
Summary: The N-acetylcysteine (NAC) associated with Ringer lactate (RL) can alleviate the inflammatory process in the kidneys and lungs of rats following intestinal obstruction and ischemia.
ACTA CIRURGICA BRASILEIRA
(2022)
Meeting Abstract
Surgery
Sergio H. B. Damous, Luciana L. Damous, Victor A. Borges, Amanda K. Fontella, Jocielle S. Miranda, Marcia K. Koike, Osmar C. Saito, Claudio A. V. Birolini, Edivaldo M. Utiyama
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Review
Ophthalmology
Camila Q. Felipe, Ana Luiza Biancardi, Vinicius T. Civile, Nelson Carvas Junior, Pedro D. Serracarbassa, Marcia K. Koike
Summary: The efficacy of mineralocorticoid receptor antagonists (MRAs) for chronic central serous chorioretinopathy (cCSCR) remains unclear. This review of randomized clinical trials found that MRAs have little to no effect on best-corrected visual acuity (BCVA) and the impact on adverse events and anatomical parameters (central subfield thickness, subretinal fluid height, and central choroidal thickness) is uncertain. These findings should be taken into account when prescribing MRAs for cCSCR.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2022)