期刊
ORGANIC LETTERS
卷 17, 期 21, 页码 5188-5191出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02512
关键词
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资金
- National Natural Science Foundation (NSF) [21272101, 21472074, 21472073]
- Fundamental Research Funds for the Central Universities [lzujbky-2014-243]
- 111 Project [J1103307]
- Program for Changjiang Scholars, and Innovative Research Team in University [IRT1138]
A palladium-catalyzed aryldifluoroalkylation of alkynes with ethyl difluoroiodoacetate and arylboronic acids as reaction partners is described. The alkyne difunctionalization process provides various aryldifluoroalkylated products in one pot under mild reaction conditions. A wide range of alkynes and diverse arylboronic acids are compatible with these reaction conditions. High reaction efficiency and broad substrate scope are the notable features of this transformation. Preliminary mechanistic investigations indicate that a difluoroalkyl radical addition pathway is involved in this transformation.
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