期刊
ORGANIC LETTERS
卷 17, 期 15, 页码 3706-3709出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01686
关键词
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资金
- National Program on Key Basic Research Project (973 programs) [2010CB833802, 2012CB721005]
- National Natural Science Foundation of China [81373304, 31100079]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13028]
- IIFSDU [2013GN014]
Genome mining is a rational approach to discovering new natural products. The genome sequence analysis of Streptomyces sp. LZ35 revealed the presence of a putative ansamycin gene cluster (nam). Constitutive overexpression of the pathway-specific transcriptional regulatory gene nam1 successfully activated the nam gene cluster, and three novel naphthalenic octaketide ansamycins were discovered with unprecedented n-pentylmalonyl-CoA or n-butylmalonyl-CoA extender units. This study represents the first example of discovering novel ansamycin scaffolds via activation of a cryptic gene cluster.
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