期刊
ORGANIC LETTERS
卷 17, 期 11, 页码 2772-2775出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01193
关键词
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资金
- NIH [GM-43214]
- NDSEG
A new primary amine catalyst for the asymmetric a-hydroxylation and a-fluorination of alpha-branched aldehydes is described. The products of the title transformations are generated in excellent yields with high enantioselectivities. Both processes can be performed within short reaction times and on gram scale. The similarity in results obtained in both reactions, combined with computational evidence, implies a common basis for stereoinduction and the possibility of a general catalytic mechanism for a-functionalizations. Promising initial results in alpha-amination and alpha-chlorination reactions support this hypothesis.
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