Review
Biochemistry & Molecular Biology
Claudine Moratal, Audrey Laurain, Mourad Naimi, Thibault Florin, Vincent Esnault, Jaap G. Neels, Nicolas Chevalier, Giulia Chinetti, Guillaume Favre
Summary: Diabetic nephropathy is characterized by proteinuria, renal dysfunction, renal fibrosis, and infiltration of macrophages derived from peripheral monocytes. Research focuses on the control of monocyte recruitment and modulation of macrophage polarization in the context of diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Joao Pedro Thimotheo Batista, Andre Oliveira Vilela de Faria, Thomas Felipe Silva Ribeiro, Ana Cristina Simoes e Silva
Summary: Diabetic cardiomyopathy is characterized by myocardial dysfunction in type 2 diabetes patients without traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease. The activation of the renin-angiotensin system (RAS), oxidative stress, lipotoxicity, maladaptive immune responses, imbalanced mitochondrial dynamics, impaired myocyte autophagy, increased myocyte apoptosis, and fibrosis all contribute to the development of diabetic cardiomyopathy. Research has shown that the RAS plays a crucial role in this condition, with over-activation of the classical RAS axis leading to increased oxidative stress, fibrosis, and cardiac remodeling, while angiotensin-(1-7) has a protective effect. ACE inhibitors and angiotensin receptor blockers have been shown to improve heart functioning and reduce the occurrence of diabetic cardiomyopathy.
Article
Medicine, Research & Experimental
Xiaohan Wu, He Li, Zhijie Wan, Ran Wang, Jing Liu, Qingfeng Liu, Haiyun Zhao, Zhehuan Wang, Huiru Zhang, Hui Guo, Caihong Qi, Xiangyue Jiao, Xiaotian Li
Summary: This study investigates the combined effects of ursolic acid and empagliflozin in treating diabetic nephropathy using a diabetic rat model. The results showed that the combination treatment was more effective in improving blood glucose, renal function indicators, inflammation levels, oxidative stress responses, and renal fibrosis compared to monotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Jin-Yan Zheng, Zhi-Tao Wei, Shu-Kun Liu, Ji-Lei Sun, Yin-Hui Mao, Yong-De Xu, Yong Yang
Summary: This study investigates the therapeutic effect of the combination of ursolic acid and insulin on diabetic nephropathy. The results show that the combined treatment has better outcomes compared to insulin-only treatment. The combination therapy improves renal function and pathological damage, reduces apoptosis and oxidative stress, and inhibits renal fibrosis and epithelial-mesenchymal transition (EMT).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Kengo Azushima, Jean -Paul Kovalik, Takahiro Yamaji, Jianhong Ching, Tze Wei Chng, Jing Guo, Jian-Jun Liu, Mien Nguyen, Rashidah Binte Sakban, Simi E. George, Puay Hoon Tan, Su Chi Lim, Susan B. Gurley, Thomas M. Coffman
Summary: This study found that in a mouse model of diabetic nephropathy, there were elevated lactate levels and impaired energy metabolism in the kidneys. Treatment with an angiotensin-receptor blocker (ARB) improved these abnormalities. Increased expression of lactate dehydrogenase isoforms, specifically LdhA in the proximal tubule, was also observed. Urinary lactate levels were found to be predictive of clinical outcomes in diabetic patients with kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura
Summary: Tubular ATRAP-mediated modulation of angiotensin II type 1 receptor signaling affects glomerular manifestations of diabetic nephropathy.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Isabel Cristina Mallostro Emerich de Abreu, Raquel Cristina Melo Ferreira de Albuquerque, Ana Beatriz Pereira Brandao, Leticia Barssotti, Livia Bruni de Souza, Fabiana Gomes Ferreira, Lilian Caroline Goncalves de Oliveira, Rodrigo Yokota, Luiz Gustavo Sparvoli, Danielle da Silva Dias, Miguel Angel Castillo Salgado, Carla Taddei, Katia De Angelis, Dulce Elena Casarini, Tatiana Sousa Cunha
Summary: Probiotic administration with Saccharomyces boulardii improved kidney structure and function in streptozotocin-induced diabetic mice, which is associated with modulation of intestinal microbiota.
Review
Pharmacology & Pharmacy
Chhanda Charan Danta, Andrew N. Boa, Sunil Bhandari, Thozhukat Sathyapalan, Shang-Zhong Xu
Summary: This review addresses the pathophysiological mechanisms, new drug targets, and potential therapeutic compounds for DKD. While some positive results have been shown in controlling DKD progression, treatment regimens to reduce mortality in patients with DKD globally have not been well developed. Therefore, the discovery of new therapeutic targets and effective target-based drugs is urgently needed.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Review
Pharmacology & Pharmacy
Jaspreet Singh, Akash Jain, Rashmi Bhamra, Vaibhav Rathi, Ashwani K. Dhingra
Summary: Nephropathy has become the most common cause of end-stage renal disease worldwide. The progression of nephropathy is caused by decreased glomerular filtration rate, damage to renal glomerular capillaries, or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The pathogenesis of nephropathy involves various mechanisms such as the generation of AGEs, elevation of growth factors, hemodynamic and metabolic factors, inflammatory mediators, oxidative stress, and dyslipidemia. Interruption in the renin-angiotensin system, oxidative stress, and dyslipidemia have shown promising results in terms of renoprotection and slowing down the progression of nephropathy.
CURRENT DRUG TARGETS
(2023)
Article
Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Neha Dagar, Pamelika Das, Priya Bisht, Amit Kumar Taraphdar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Diabetic nephropathy is a persistent microvascular problem of diabetes mellitus characterized by elevated albumin excretion in urine and impaired renal function. The pathogenesis is multifactorial and requires novel treatment approaches beyond glucose and blood pressure control.
Article
Biochemistry & Molecular Biology
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
Summary: This study demonstrates that 3-OHB delays the progression of diabetic nephropathy (DN) by enhancing autophagy and inhibiting oxidative stress, as observed in both in vivo and in vitro models.
Article
Medicine, Research & Experimental
Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragao, Rodolfo de Paula Vieira, Nadia Bertoncello, Nestor Schor, Flavio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha
Summary: The study aimed to investigate the effects of resistance training on renal renin-angiotensin system components and inflammatory mediators in diabetic rats. The results showed that resistance training improved kidney function in diabetic rats by modulating intrarenal RAS towards the ACE2/Ang 1-7 axis and reducing inflammatory cytokines levels.
Article
Medicine, General & Internal
Piero Ruggenenti, Monica Cortinovis, Aneliya Parvanova, Matias Trillini, Ilian P. Iliev, Antonio C. Bossi, Antonio Belviso, Maria C. Aparicio, Roberto Trevisan, Stefano Rota, Annalisa Perna, Tobia Peracchi, Nadia Rubis, Davide Martinetti, Silvia Prandini, Flavio Gaspari, Fabiola Carrara, Salvatore De Cosmo, Giancarlo Tonolo, Ruggero Mangili, Giuseppe Remuzzi
Summary: Combined therapy with ACE inhibitor and ARB did not show superior efficacy in preventing microalbuminuria compared to monotherapy with benazepril or valsartan in normoalbuminuric type 2 diabetic patients.
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Meeting Abstract
Cardiac & Cardiovascular Systems
Taishi Nakamura, Hisao Ogawa
JOURNAL OF CARDIAC FAILURE
(2015)
Article
Medicine, Research & Experimental
Taishi Nakamura, Mark J. Ranek, Dong I. Lee, Virginia Shalkey Hahn, Choel Kim, Philip Eaton, David A. Kass
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Cardiac & Cardiovascular Systems
Taishi Nakamura, Guangshuo Zhu, Mark J. Ranek, Kristen Kokkonen-Simon, Manling Zhang, Grace E. Kim, Kenichi Tsujita, David A. Kass
CIRCULATION-HEART FAILURE
(2018)
Article
Cardiac & Cardiovascular Systems
Shinsuke Hanatani, Yasuhiro Izumiya, Yoshiro Onoue, Tomoko Tanaka, Masahiro Yamamoto, Toshifumi Ishida, Satoru Yamamura, Yuichi Kimura, Satoshi Araki, Yuichiro Arima, Taishi Nakamura, Koichiro Fujisue, Seiji Takashio, Daisuke Sueta, Kenji Sakamoto, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Kenichi Tsujita
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Manling Zhang, Eiki Takimoto, Dong-ik Lee, Celio X. C. Santos, Taishi Nakamura, Steven Hsu, Aiyang Jiang, Takahiro Nagayama, Djahida Bedja, Yuan Yuan, Philip Eaton, Ajay M. Shah, David A. Kass
Article
Cardiac & Cardiovascular Systems
Yoshiro Onoue, Yasuhiro Izumiya, Shinsuke Hanatani, Toshifumi Ishida, Yuichiro Arima, Satoru Yamamura, Yuichi Kimura, Satoshi Araki, Masanobu Ishii, Taishi Nakamura, Yu Oimatsu, Kenji Sakamoto, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Kenichi Tsujita
CIRCULATION JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Masafumi Takae, Eiichiro Yamamoto, Koichiro Fujisue, Fumi Oike, Taiki Nishihara, Daisuke Sueta, Hiroki Usuku, Kota Motozato, Miwa Ito, Shinsuke Hanatani, Hisanori Kanazawa, Yuichiro Arima, Seiji Takashio, Taishi Nakamura, Satoru Suzuki, Kenji Sakamoto, Yasuhiro Izumiya, Hirofumi Soejima, Sunao Kojima, Hiroshige Yamabe, Koichi Kaikita, Kenichi Tsujita
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Junichi Matsubara, Seigo Sugiyama, Koichi Sugamura, Taishi Nakamura, Yukio Fujiwara, Eiichi Akiyama, Hirofumi Kurokawa, Toshimitsu Nozaki, Keisuke Ohba, Masaaki Konishi, Hirofumi Maeda, Yasuhiro Izumiya, Koichi Kaikita, Hitoshi Sumida, Hideaki Jinnouchi, Kunihiko Matsui, Shokei Kim-Mitsuyama, Motohiro Takeya, Hisao Ogawa
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Satoru Yamamura, Yasuhiro Izumiya, Satoshi Araki, Toshifumi Ishida, Masahiro Yamamoto, Taishi Nakamura, Yuichiro Arima, Kenichi Tsujita
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee, David A. Kass
Article
Medicine, Research & Experimental
Kristen M. Kokkonen-Simon, Amir Saberi, Taishi Nakamura, Mark J. Ranek, Guangshuo Zhu, Djahida Bedja, Michaela Kuhn, Marc K. Halushka, Dong Ik Lee, David A. Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Taishi Nakamura, Guangshuo Zhu, Mark J. Ranek, Kenichi Tsujita, David Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark J. Ranek, Kristen M. Kokkonen, Ronald J. Holewinski, Dong I. Lee, Taishi Nakamura, Guangshuo Zhu, Masayuki Sasaki, Jennifer E. Van Eyk, David A. Kass
Article
Peripheral Vascular Disease
Guangshuo Zhu, Dieter Groneberg, Gautam Sikka, Daijiro Hori, Mark J. Ranek, Taishi Nakamura, Eiki Takimoto, Nazareno Paolocci, Dan E. Berkowitz, Andreas Friebe, David A. Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark J. Ranek, Taishi Nakamura, Ronald Holewinski, Dong-ik Lee, Guangshuo Zhu, Khalid Chakir, Philip Eaton, Jennifer Van Eyk, David A. Kass