☆ 4.8 Article

Lewis Acid Catalyzed Annulation of Nitrones with Oxiranes, Aziridines, and Thiiranes

ORGANIC LETTERS (2015)

期刊

ORGANIC LETTERS

卷 17, 期 18, 页码 4506-4509

出版社

AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.5b02195

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Chemistry, Organic

资金

Swedish Research Council
Lars Hierta Memorial Foundation
Carl Trygger Foundation

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摘要

A highly selective Lewis acid catalyzed annulation of three-membered heterocycles with nitrones has been developed. Oxiranes, aziridines, and thiiranes were used as substrates for the synthesis of various six-membered heterocycles using Al or In catalysts. This catalytic protocol demonstrates a broad substrate scope and provides access to new structural motifs in high yields and in excellent selectivity under mild reaction conditions.

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