Orthostatic hypotension in genetically related hypertensive and normotensive individuals

Objectives Prevalence and determinants of orthostatic hypotension remain largely unexplored in younger individuals without significant burden of chronic diseases. Methods We investigated frequency and main associations of impaired orthostatic response in a cohort of 469 middle-aged hypertensive patients and 453 of their normotensive first-degree relatives. Results 13.4% of hypertensive and 5.5% of normotensive study participants were found to have orthostatic hypotension. In a backward logistic regression the following determinants of orthostatic hypotension were identified: sex [female, odds ratio (OR) 2.45, 95% confidence interval (CI) 1.14-5.25, P = 0.022], reduced glomerular filtration rate [OR (per ml/min/1.73m(2)) 0.97, 95% CI 0.94-0.99, P = 0.002], systolic (OR (per mmHg) 1.02,95% CI 1.00-1.05, P = 0.047] and diastolic blood pressure [OR (per mmHg) 1.04, 95% CI 1.00-1.09, P = 0.033], and anti hypertensive treatment (OR 0.41, 95% CI 0.18-0.93, P = 0.034). In hypertensive patients use of angiotensin-converting enzyme inhibitors was related to lower orthostatic hypotension frequency. Percentage of orthostatic hypotension-positive patients in the highest blood pressure stratum (>= 160 mmHg) decreased from 20.2 to 7.6, when diagnostic criteria of orthostatic hypotension were adjusted for mean systolic orthostatic reaction (2 SD value: 30 mmHg). During follow-up (t = 6.6 years) individuals with impaired orthostatic response showed a trend towards increased total mortality (OR 2.16, 95% CI 0.97-4.80, P = 0.06) in a crude model. Conclusion Prevalence of orthostatic hypotension in hypertensive patients is higher than in their normotensive first-degree relatives. Independently of age, sex, and elevated blood pressure, orthostatic hypotension may be additionally determined by impaired renal function. Anti hypertensive treatment seems to protect from orthostatic hypotension, in particular, use of angiotensin-converting enzyme inhibitors in hypertensive patients. The diagnostic criteria of orthostatic hypotension may need adjustment for initial supine systolic blood pressure to increase clinical accuracy. The prognostic value of impaired orthostatic response regarding risk of cardiovascular disease and mortality remains uncertain and requires further studies. J Hypertens 27:976-982 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.