Article
Medicine, Research & Experimental
Nehal R. Patel, K. C. Rajan, Avery Blanks, Yisu Li, Minolfa C. Prieto, Stryder M. Meadows
Summary: This study investigates the role of ATP6AP2 in blood vessel development using a mouse model and demonstrates its critical role in developmental and pathological angiogenesis, highlighting its regulatory functions in cell migration, cell polarity, and extracellular matrix composition.
Article
Urology & Nephrology
Monique E. Cho, Carol Sweeney, Nora Fino, Tom Greene, Nirupama Ramkumar, Yufeng Huang, Ana C. Ricardo, Tariq Shafi, Rajat Deo, Amanda Anderson, Katherine T. Mills, Alfred K. Cheung
Summary: In patients with chronic kidney disease (CKD), plasma concentrations of prorenin and renin showed a decreasing trend, especially in those with severe conditions at baseline. Women and non-Hispanic blacks had lower prorenin and renin values at year 1, while diabetes, lower eGFR, and use of certain medications were associated with higher levels of prorenin and renin.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Review
Medical Laboratory Technology
Ilja Burdman, Bjoern B. Burckhardt
Summary: Renin and prorenin have been areas of research interest in the renin-angiotensin-aldosterone system for decades, with studies showing varying associations with disease. Studies in paediatrics are limited and show an age-dependent decline in renin levels in newborns compared to adolescents. Sample handling and quantification methods remain challenges, highlighting the need for accurate procedures in assessing renin and prorenin levels.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Venkateswara R. Gogulamudi, Danielle Y. Arita, Camille R. T. Bourgeois, Justine Jorgensen, Jing He, William C. Wimley, Ryosuke Satou, Alexis A. Gonzalez, Minolfa C. Prieto
Summary: Evidence suggests that high glucose conditions stimulate the translocation of PRR to the plasma membrane in CD cells, leading to activation of downstream fibrotic factors. This may represent a novel mechanism underlying the development of tubulointerstitial fibrosis in diabetic kidneys.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sae Saigo, Tabito Kino, Kotaro Uchida, Takuya Sugawara, Lin Chen, Michiko Sugiyama, Kengo Azushima, Hiromichi Wakui, Kouichi Tamura, Tomoaki Ishigami
Summary: The study demonstrated that overexpression of the (P)RR gene in mice resulted in hypertension, alkalized urine, lower osmolality, and Na+ excretion. It was found that (P)RR may function as a V-ATPase in renal tubules. Furthermore, mating (P)RR-TG mice with ARen2-TG mice to generate double transgenic mice (DT-TG) revealed that intracellular renin could be a ligand for (P)RR in tubules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andrea Lopez-Lopez, Begona Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, Maria Garcia-Garrote, Carmen Diaz-Ruiz, Ana Munoz, Jose L. Labandeira-Garcia
Summary: The dysregulation of tissue RAS plays a role in oxidative and inflammatory responses. This study focused on PRR in microglia during neuroinflammatory responses, finding that (pro)renin induced a pro-inflammatory response in microglia through various mechanisms including upregulation of NADPH-oxidase and Rho-kinase activities, downregulation of autophagy, and upregulation of inflammasome activity. Additionally, microglial PRR activation was linked to deleterious effects on dopaminergic cells, which could be blocked by a Rho-kinase inhibitor.
Article
Peripheral Vascular Disease
Sayuki Kawamura, Kazumi Fujimoto, Akinori Hayashi, Yuji Kamata, Ibuki Moriguchi, Naoyuki Kobayashi, Masayoshi Shichiri
Summary: Although the measurement of plasma prorenin levels is still unavailable in clinical practice, this study found that utilizing a sandwich enzyme-linked immunosorbent assay that captures posttranslationally modified prorenins with their prosegment antibodies, plasma and serum prorenin concentrations can be measured in patients with diabetes mellitus, hypertension and/or renal disease. The results showed no significant difference compared to healthy controls, but were significantly higher than previously reported levels using conventional assay kits. Furthermore, the study found that plasma prorenin levels were negatively correlated with body weight, serum albumin levels, and serum creatinine levels, while the use of loop diuretics was associated with elevated plasma prorenin levels.
HYPERTENSION RESEARCH
(2022)
Review
Urology & Nephrology
Minolfa C. Prieto, Alexis A. Gonzalez, Bruna Visniauskas, L. Gabriel Navar
Summary: The intrarenal renin-angiotensin system is crucial for regulating kidney function and blood pressure, especially the control in the collecting duct plays a key role in the development of hypertension and kidney injury.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Obstetrics & Gynecology
Rosalieke E. Wiegel, A. H. Jan Danser, Linette van Duijn, Sten P. Willemsen, Joop S. E. Laven, Eric A. P. Steegers, Esther B. Baart, Regine P. M. Steegers-Theunissen
Summary: This study investigated whether circulating maternal prorenin could serve as a proxy for oocyte and preimplantation embryo development. The results showed that high circulating maternal prorenin concentrations were associated with a larger oocyte area, faster cleavage divisions, and increased chance of successful implantation.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday
Summary: The PRR abundant in extracellular vesicles shed by osteoclasts stimulates the activity of (pro)renin. This discovery reveals a novel mechanism for intercellular regulation by extracellular vesicles, with direct implications for bone biology.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Rosalieke E. Wiegel, Frauke Von Versen-Hoynck, Regine P. M. Steegers-Theunissen, Eric A. P. Steegers, A. H. Jan Danser
Summary: In pregnancy, the renin-angiotensin-aldosterone system undergoes major changes to adapt to the increased demand for blood supply for the growing fetus. Prorenin, released from various sources during preconception and pregnancy, plays a crucial role and may have implications for conditions like preeclampsia. Understanding the role of prorenin during these periods may lead to the development of tools for diagnosing and preventing reproductive complications in the future.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Rosalieke E. Wiegel, Frauke Von Versen-Hoeynck, Regine P. M. Steegers-Theunissen, Eric A. P. Steegers, A. H. Jan Danser
Summary: Pregnancy involves significant cardiovascular, renal, and endocrine changes, with the renin-angiotensin-aldosterone system playing a key role in providing adequate blood supply for the growing fetus. Prorenin, released in large amounts during this adaptation process from the ovary and uteroplacental unit, is the focus of research on its effects during pregnancy, particularly related to conditions like preeclampsia. Future research directions include understanding the long-term consequences of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and developing tools for diagnosing or preventing reproductive complications.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Pediatrics
Ihor Yosypiv
Summary: Mutations in genes of the renin-angiotensin system can lead to congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. Understanding the underlying mechanisms of CAKUT is crucial for improving the care of affected children. Recent advances have shed light on how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.
PEDIATRIC NEPHROLOGY
(2021)
Article
Plant Sciences
Yimin Chang, Qian Che, Li Xing, Chuanteng Ma, Yaxin Han, Tianjiao Zhu, Blaine A. Pfeifer, Jixing Peng, Guojian Zhang, Dehai Li
Summary: Five new p-terphenyl derivatives, named nocarterphenyls D-H, were isolated and characterized from the cultures of Nocardiopsis sp. HDN154086 with potential antibacterial activity, among which compound 2 displayed remarkable activity against MRSA exceeding the positive control ciprofloxacin.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Endocrinology & Metabolism
Takashi Yamaguchi, Satoshi Morimoto, Chikahito Suda, Atsuhiro Ichihara, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno
Summary: This study examined the relationship between soluble (pro)renin receptor (s[P]RR) levels and body composition and metabolic factors in severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG). The results showed that blood s(P)RR levels were high in these patients and decreased after weight loss through LSG. The study suggests that blood s(P)RR levels in obese patients may be associated with visceral fat and play a role in insulin resistance and renal damage mechanisms associated with obesity.
Review
Cardiac & Cardiovascular Systems
Charlotte D. C. C. van der Heijden, Jaap Deinum, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
CARDIOVASCULAR RESEARCH
(2018)
Letter
Endocrinology & Metabolism
Marieke S. Velema, Tanja Dekkers, Ad R. M. M. Hermus, Henri J. L. M. Timmers, Johan Langenhuijsen, Mark Arntz, Benno Kusters, Graeme Eisenhofer, Jacques W. M. Lenders, Jaap Deinum
CLINICAL ENDOCRINOLOGY
(2018)
Article
Primary Health Care
Sabine C. Kayser, Bianca W. M. Schalk, Wim J. C. de Grauw, Tjard R. Schermer, Reinier P. Akkermans, Jacques W. M. Lenders, Jaap Deinum, Marion C. J. Biermans
Article
Endocrinology & Metabolism
Marieke S. Velema, Jannie M. Terlouw, Aline H. de Nooijer, Marjan D. Nijkamp, Nele Jacobs, Jaap Deinum
HORMONE AND METABOLIC RESEARCH
(2018)
Article
Clinical Neurology
Tessa van Middelaar, Tanja E. Argillander, Floris H. B. M. Schreuder, Jaap Deinum, Edo Richard, Catharina J. M. Klijn
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Van Den Berg, A. C. van Mil, J. Deinum, P. H. van den Broek, G. A. Rongen, H. Monajemi, D. H. Thijssen, N. P. Riksen
Article
Endocrinology & Metabolism
Marieke S. Velema, Evie J. M. Linssen, Ad R. M. M. Hermus, Hans J. M. M. Groenewoud, Gert-Jan van der Wilt, Antonius E. van Herwaarden, Jacques W. M. Lenders, Henri J. L. M. Timmers, Jaap Deinum
ENDOCRINE CONNECTIONS
(2018)
Article
Endocrinology & Metabolism
Marieke Stientje Velema, Aline de Nooijer, Ad R. M. M. Hermus, Henri J. L. M. Timmers, Jacques W. M. Lenders, Olga Husson, Jaap Deinum
ENDOCRINE CONNECTIONS
(2019)
Article
Endocrinology & Metabolism
Youichi Ohno, Mitsuhide Naruse, Felix Beuschlein, Florentine Schreiner, Mirko Parasiliti-Caprino, Jaap Deinum, William M. Drake, Francesco Fallo, Carmina T. Fuss, Marianne A. Grytaas, Takamasa Ichijo, Nobuya Inagaki, Miki Kakutani, Darko Kastelan, Ivana Kraljevic, Takuyuki Katabami, Tomaz Kocjan, Silvia Monticone, Paolo Mulatero, Sam O'Toole, Hiroki Kobayashi, Masakatsu Sone, Mika Tsuiki, Norio Wada, Tracy Ann Williams, Martin Reincke, Akiyo Tanabe
Summary: AVS is the standard lateralization technique in PA. International data showed lower rates of unilateral PA and adrenalectomy in Japanese centers compared to European centers. Reasons for not performing adrenalectomy in patients with unilateral PA were more likely to be physician-derived in Japan and patient-derived in Europe.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Daan H. H. M. Viering, Anneke P. Bech, Jeroen H. F. de Baaij, Eric J. Steenbergen, A. H. Jan Danser, Jack F. M. Wetzels, Rene J. M. Bindels, Jaap Deinum
Summary: This study reports a case of a 28-year-old male with a homozygous truncating mutation in AGTR1 gene, demonstrating that even truncating loss-of-function mutations in AGTR1 are compatible with life and relatively good GFR. The patient-tailored functional test showed that high doses of fludrocortisone induced renal potassium excretion and mitigated salt-wasting, providing evidence for the prescription of fludrocortisone in such patients.
PEDIATRIC NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolaos G. Bliziotis, Leo A. J. Kluijtmans, Gerjen H. Tinnevelt, Parminder Reel, Smarti Reel, Katharina Langton, Mercedes Robledo, Christina Pamporaki, Alessio Pecori, Josie Van Kralingen, Martina Tetti, Udo F. H. Engelke, Zoran Erlic, Jasper Engel, Timo Deutschbein, Svenja Noelting, Aleksander Prejbisz, Susan Richter, Jerzy Adamski, Andrzej Januszewicz, Filippo Ceccato, Carla Scaroni, Michael C. Dennedy, Tracy A. Williams, Livia Lenzini, Anne-Paule Gimenez-Roqueplo, Eleanor Davies, Martin Fassnacht, Hanna Remde, Graeme Eisenhofer, Felix Beuschlein, Matthias Kroiss, Emily Jefferson, Maria-Christina Zennaro, Ron A. Wevers, Jeroen J. Jansen, Jaap Deinum, Henri J. L. M. Timmers
Summary: This study aimed to establish signatures for different forms of endocrine hypertension (EHT) and investigate unbiased disease biomarkers. Plasma samples from 13 biobanks across seven countries were analyzed using untargeted NMR metabolomics. While signatures that could differentiate different forms of EHT were found, confounding effects related to sample center and age were also identified. Various approaches were applied to correct these confounding effects, but no biomarkers for differentiating primary hypertension from EHT could be identified.
Article
Biochemistry & Molecular Biology
Smarti Reel, Parminder S. Reel, Zoran Erlic, Laurence Amar, Alessio Pecori, Casper K. Larsen, Martina Tetti, Christina Pamporaki, Cornelia Prehn, Jerzy Adamski, Aleksander Prejbisz, Filippo Ceccato, Carla Scaroni, Matthias Kroiss, Michael C. Dennedy, Jaap Deinum, Graeme Eisenhofer, Katharina Langton, Paolo Mulatero, Martin Reincke, Gian Paolo Rossi, Livia Lenzini, Eleanor Davies, Anne-Paule Gimenez-Roqueplo, Guillaume Assie, Anne Blanchard, Maria-Christina Zennaro, Felix Beuschlein, Emily R. Jefferson
Summary: Hypertension is a major global health problem with high prevalence and complex associated health risks. Primary hypertension is the most common form, while the reasons behind it are largely unknown. Endocrine hypertension is another complex form often misdiagnosed as primary hypertension. This study used targeted metabolomics and machine learning methods to predict key biomarkers and successfully classify different subtypes of hypertension.
Review
Urology & Nephrology
Daan H. H. M. Viering, Lars Vermeltfoort, Rene J. M. Bindels, Jaap Deinum, Jeroen H. F. de Baaij
Summary: This systematic review investigated the presence of electrolyte disorders in patients with mitochondrial cytopathies and found that electrolyte disorders are commonly reported in these patients. The study highlights the importance of recognizing mitochondrial diseases as a cause of disturbances in electrolyte homeostasis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Bas C. Stunnenberg, Jaap Deinum, Tom Nijenhuis, Frans Huysmans, Gert Jan van der Wilt, Baziel G. M. van Engelen, Frans van Agt