Article
Peripheral Vascular Disease
Christine Y. Bakhoum, Matthew B. Matheson, Jason H. Greenberg, Susan L. Furth, Joachim H. Ix, Pranav S. Garimella
Summary: The study found no association between urine uromodulin levels and blood pressure in children with chronic kidney disease. Further research is needed to confirm this finding in healthy pediatric cohorts.
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Peripheral Vascular Disease
Sang Gon Yoon, Seung Ku Lee, Seong Hwan Kim, Chol Shin, Sang Youb Han
Summary: This study found that differences in eGFR are associated with different 24-hour ABPM patterns in individuals without chronic kidney disease. ABPM can identify individuals with a nondipper status in this population.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Mark M. Mitsnefes, Yunwen Xu, Derek K. Ng, Garick Hill, Thomas Kimball, Susan L. Furth, Bradley A. Warady
Summary: Diastolic dysfunction is an early cardiac abnormality in patients with chronic kidney disease, with E/e' ratio being a marker to assess it. Abnormal E/e' ratio is associated with younger age, lower glomerular filtration rate, lower hemoglobin, hypertension, left ventricular hypertrophy, and sustained hypertension. Ambulatory blood pressure may better identify chronic kidney disease in children at risk for subclinical cardiac dysfunction compared to casual blood pressure.
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pathology
Rouvick M. Gama, Kathryn Griffiths, Royce P. Vincent, Adrien Michael Peters, Kate Bramham
Summary: Accurate diagnosis, classification, and risk stratification for chronic kidney disease (CKD) are important for early recognition and optimal care. Creatinine-based glomerular filtration rate (GFR), urinary albumin: creatinine ratio (UACR), and the kidney failure risk equation (KFRE) are important tools for achieving this, but understanding their limitations is crucial for optimal implementation.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Young Su Joo, Ki Heon Nam, Jong Hyun Jhee, Hae-Ryong Yun, Sangmi Lee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Summary: This study found that body weight fluctuations were significantly associated with an increased risk of rapid kidney function decline in individuals with normal kidney function. The higher the body weight fluctuations, the more common rapid eGFR decline was observed. Individuals in the highest ASV tertile group faced a higher risk of rapid eGFR decline.
Article
Peripheral Vascular Disease
Yunmi Kim, Jayoun Kim, Sung Woo Lee, Suah Sung, Tae-Hyun Yoo, Kyu-Beck Lee, Young-Hwan Hwang, Taehee Kim, Sun Woo Kang, Yeong Hoon Kim, Kook-Hwan Oh
Summary: This study found no significant difference in renal outcomes between ambulatory blood pressure monitoring (ABPM) and conventional office blood pressure monitoring for controlling hypertension in patients with chronic kidney disease (CKD).
JOURNAL OF HYPERTENSION
(2021)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Peripheral Vascular Disease
Sean D. Stocker, Jacob B. Sullivan
Summary: TRPV1 channels are involved in 2K1C renovascular hypertension, regulating renal afferent and sympathetic nerve activity, glomerular filtration rate, and arterial blood pressure.
Article
Medical Laboratory Technology
Ulf Nyman, Jonas Bjork, Pierre Delanaye, Alexandre Lahens, Hans Pottel, Emmanuelle Vidal-Petiot, Martin Flamant
Summary: GFR estimating equations can be re-expressed to include rescaled creatinine (sCr/Q) and used across populations with different creatinine generation if population-specific average creatinine concentrations (Q-values) for healthy persons are established.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Urology & Nephrology
Edouard L. Fu, Andrew S. Levey, Josef Coresh, Carl-Gustaf Elinder, Joris I. Rotmans, Friedo W. Dekker, Julie M. Paik, Peter Barany, Morgan E. Grams, Lesley A. Inker, Juan-Jesus Carrero
Summary: Cystatin C is recommended as a confirmatory test to eGFR when more precise estimates are needed for clinical decision making. However, it is uncertain whether eGFR(cr-cys) is the most accurate estimate in real-world settings, especially when there are large discordances between eGFR(cr) and eGFR(cys).
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Young Su Joo, Tyler Hyungtaek Rim, Hee Byung Koh, Joseph Yi, Hyeonmin Kim, Geunyoung Lee, Young Ah Kim, Shin-Wook Kang, Sung Soo Kim, Jung Tak Park
Summary: A predictive risk score for chronic kidney disease (CKD) was derived from a deep learning algorithm using retinal photographs. The Reti-CKD score showed superior performance in predicting CKD incidence compared to eGFR-based methods. Validation was done in two longitudinal cohorts, demonstrating its effectiveness in stratifying future CKD risk.
NPJ DIGITAL MEDICINE
(2023)
Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Infectious Diseases
Silvijus Abramavicius, Vaidotas Galaune, Agile Tunaityte, Astra Vitkauskiene, Gintautas Gumbrevicius, Aurelija Radzeviciene, Romaldas Maciulaitis
Summary: The study found that current eGFR estimators for patients with acute kidney injury (AKI) pose risks of inaccuracy in renal function assessment and drug dosing, with the exception of the Cockcroft-Gault estimator, which is more appropriate.
Article
Endocrinology & Metabolism
Flavia Agata Cimini, Ilaria Barchetta, Laura Bertoccini, Valentina Ceccarelli, Marco Giorgio Baroni, Olle Melander, Maria Gisella Cavallo
Summary: The study showed that elevated pro-NT levels in T1D patients predict the development of adverse metabolic profile, leading to a higher cardiovascular risk profile at the 10-year follow-up. Pro-NT serves as a novel predictor/marker of cardiovascular risk factors in adults with T1D.
ACTA DIABETOLOGICA
(2022)
Article
Medicine, General & Internal
Torgny Wessman, Rafid Tofik, Thoralph Ruge, Olle Melander
Summary: This study assessed whether biomarkers associated with comorbidity burden can predict outcome in acute dyspnea patients. The findings suggest that the biomarker score is superior to the multimorbidity score in predicting both long and short-term mortality. Measurement of the biomarker score may serve as a biological fingerprint of the multimorbidity score at the emergency department, aiding in risk prediction, treatment decisions, and follow-up needs.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Torgny Wessman, Johan Arnlov, Axel Carl Carlsson, Ulf Ekelund, Per Wandell, Olle Melander, Toralph Ruge
Summary: The study found that increased length of stay at the emergency department was slightly associated with higher short-term mortality rates in patients with lower clinical urgency or those discharged from the ED. However, for patients with higher priority levels, the opposite trend was observed.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Kevin Bronton, Torgny Wessman, Klas Gransbo, Janin Schulte, Oliver Hartmann, Olle Melander
Summary: This study demonstrates that plasma levels of bio-ADM sampled at ED presentation in patients with acute dyspnea are independently associated with 90-day mortality and hospitalization risk, indicating the need for decongestive therapy.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Bevilacqua, Paolo De Togni, Filippo Cattazzo, Davide Dell'Atti, Andrea Dalbeni, Fulvia Mazzaferri, Evelina Tacconelli, Afshin Farzaneh-Far, Cristiano Fava, Pietro Minuz, Simone Romano
Summary: Evidence shows that the cardiovascular system is involved in patients with COVID-19. Evaluating subclinical cardiac involvement is crucial for risk stratification. Left ventricular global longitudinal strain (LVGLS) can help identify high-risk patients and guide early treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Filippo Cattazzo, Francesco Inglese, Andrea Dalbeni, Salvatore Piano, Martino Francesco Pengo, Martina Montagnana, Davide Dell'Atti, Francesco Soliani, Andrea Cascella, Stefano Vicini, Carmine Gambino, Pietro Minuz, Roberto Vettor, Gianfranco Parati, Paolo Angeli, Cristiano Fava
Summary: This study evaluated the performance of two non-invasive respiratory function indices in predicting a clinically relevant composite outcome in COVID-19 pneumonia patients. The ROX index and the SatO2/FiO2 ratio showed comparable accuracy to the traditional PaO2/FiO2 ratio in predicting intubation or death for patients admitted to medical wards.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ayesha Fawad, Andreas Bergmann, Janin Schulte, Zahra A. Butt, Peter M. Nilsson, Louise Bennet, Marju Orho-Melander, Olle Melander
Summary: This study found that high levels of proneurotensin are associated with increased mortality risk in middle-aged individuals, particularly for deaths related to cardiovascular disease, digestive tract disease, mental and behavioral disease, and unspecific causes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Hematology
Eric Manderstedt, Christer Hallden, Christina Lind-Hallden, Johan Elf, Peter J. Svensson, Gunnar Engstrom, Olle Melander, Aris Baras, Luca A. Lotta, Bengt Zoller, Regeneron Genetics Center
Summary: This study aimed to investigate the relationship between THBD gene variations and VTE. The results showed that rare qualifying THBD variants were associated with VTE, suggesting their contribution to the development of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Filip Ottosson, Einar Smith, Ulrika Ericson, Louise Brunkwall, Marju Orho-Melander, Salvatore Di Somma, Paola Antonini, Peter M. Nilsson, Celine Fernandez, Olle Melander
Summary: Lean individuals with an obesity-related metabolome have an increased risk for type 2 diabetes and all-cause mortality compared with lean individuals with a healthy metabolome.
Article
Medicine, General & Internal
Sofia Enhorning, Olle Melander, Gunnar Engstrom, Solve Elmstahl, Lars Lind, Peter M. Nilsson, Mats Pihlsgard, Simon Timpka
Summary: A study in Malmo, Sweden found that copeptin, a surrogate marker of vasopressin, exhibits a distinct seasonal variation with a peak in winter and a nadir in late summer. This seasonal variation may be related to an increased risk of cardiometabolic disease.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Alice Giontella, Luca A. Lotta, Aris Baras, Pietro Minuz, Dipender Gill, Olle Melander, Cristiano Fava
Summary: This study found a direct association between genetically predicted calcium level and diastolic blood pressure, and a weaker association with systolic blood pressure. No clear association was found for genetically predicted calciotropic hormone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Maria-Chiara Ambrosetti, Giulia Battocchio, Stefania Montemezzi, Filippo Cattazzo, Tissjana Bejko, Evelina Tacconelli, Pietro Minuz, Ernesto Crisafulli, Cristiano Fava, Giancarlo Mansueto
Summary: This study shows for the first time that COVID-19 patients have significantly enlarged segmental and subsegmental vessel calibers in the lungs, indicating distinct pathophysiology compared to other inflammatory and thromboembolic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Anita Morandi, Claudia Piona, Massimiliano Corradi, Marco Marigliano, Alice Giontella, Silvia Orsi, Federica Emiliani, Angela Tagetti, Denise Marcon, Cristiano Fava, Claudio Maffeis
Summary: This study aimed to assess the association between overall oxidative stress, oxidized lipoproteins, and glycemic variability with early macro-vascular damage in type 1 diabetes (T1D), in addition to traditional risk factors. The results showed that oxidative stress, gender, insulin dose, diabetes duration, and changes in lipids and blood pressure contributed to the variance of early vascular damage in young patients with T1D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Simone Romano, Denise Marcon, Lorella Branz, Angela Tagetti, Giada Monami, Alice Giontella, Francesca Malesani, Luca Pecoraro, Pietro Minuz, Milena Brugnara, Cristiano Fava
Summary: Subclinical cardiovascular damage, including increased RWT and high cIMT, is already present in children with ADPKD. RWT is significantly correlated with cDC and PWV, indicating an association between vascular stiffening and cardiac remodeling. It is noteworthy that subclinical cardiovascular damage may occur before a decline in glomerular filtration rate, even in the absence of renal function abnormalities.
MEDICINA-LITHUANIA
(2023)
Article
Cardiac & Cardiovascular Systems
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Malarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Arnlov, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans-Peter Brunner-La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G. F. Cleland, James P. Cook, Simon de Denus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Doerr, Samuel C. Dudley, Gunnar Engstrom, Tonu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, Rene Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daniel F. Guobjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van der Harst, Asa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay-Tee Khaw, Marcus E. Kleber, Lars Kober, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried Maerz, John J. V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton-Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N. A. Palmer, Guillaume Pare, Markus Perola, Louis-Philippe Lemieux Perreault, Eliana Portilla-Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P. R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garoar Sveinbjornsson, Mari-Liis Tammesoo, Jean-Claude Tardif, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Guomundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Voelker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges-Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie-Pierre Dube, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith
Summary: HERMES consortium aims to identify the genetic and molecular basis of heart failure, with 51 studies from 11 countries currently included. The studies predominantly recruited male participants with heart failure, and the mean age ranged from 54 to 84 years.
