Article
Cardiac & Cardiovascular Systems
Lucas Busch, Yvonne Heinen, Manuel Stern, Georg Wolff, Goksen Ozaslan, Konstantina Tzetou, Roberto Sansone, Christian Heiss, Malte Kelm
Summary: Angioplasty of flow-limiting stenoses in patients with peripheral artery disease can lower aortic and brachial blood pressure, especially in patients with more severe lesions and higher baseline systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Physiology
Matthew P. Harber, Allison McCurry, Nicholas Carlini, Brandon Kistler, Bradley S. Fleenor
Summary: The study found that in healthy middle-aged men, pre-exercise caffeine ingestion led to higher central and peripheral systolic blood pressures, PWV, and AIx at 30 minutes post-exercise, indicating an increased left ventricular workload which may have implications for cardiovascular event risk.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Minyoung Kim, Ruda Lee, Nyeonju Kang, Moon-Hyon Hwang
Summary: This study investigated the impact of limb-specific resistance training on arterial stiffness in young adults. Results showed that upper-limb resistance training could decrease central artery wave reflection and potentially improve local peripheral artery stiffness in healthy young adults.
APPLIED SCIENCES-BASEL
(2021)
Article
Physiology
Norsuhana Omar, Boon Seng Yeoh, Kalaivani Chellappan, Sara Zijiun Chui, Norizam Salamt, Amilia Aminuddin
Summary: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in Malaysia and worldwide. The prevalence of risk factors such as hypertension, dyslipidemia, smoking, and obesity has contributed to this trend. Increased physical activity, as assessed by pulse wave velocity (PWVCF), augmentation index (AI), and finger photoplethysmography fitness (PPGF) index, has been associated with improved CVD risk factors. However, the effects of long-term exercise on PPGF index are still unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Mariana P. de Souza, Paulo Cesar Lopes, Gabriel Bazo, Paulo Ricardo H. Rocha, Daniela Aparecida Lorencini, Heloisa Bettiol, Marco Antonio Barbieri, Eduardo B. Coelho
Summary: The study aimed to determine the most accurate diagnostic criteria of arterial hypertension (AH) for detecting early vascular aging (EVA). The results of the cross-sectional study on 1775 participants showed that the 2017 ACC/AHA criteria had higher accuracy in diagnosing EVA.
Article
Cardiac & Cardiovascular Systems
Egidija Rinkuniene, Vilma Dzenkeviciute, Zaneta Petrulioniene, Egle Majauskiene, Ligita Ryliskyte, Roma Puronaite, Jolita Badariene, Rokas Navickas, Aleksandras Laucevicius
Summary: The study found that elevated triglycerides are independently associated with increased arterial stiffness and thickness, specifically cfPWV, crPWV, and cIMT, potentially modifying cardiovascular disease risk in patients with metabolic syndrome.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Takanobu Okamoto, Yuto Hashimoto, Madoka Ogawa
Summary: Increased arterial stiffness, as indicated by AI@75, is associated with lower pulmonary function in postmenopausal women, as measured by FVC, FEV1, and FEV1/FVC ratio.
HEART LUNG AND CIRCULATION
(2021)
Article
Cardiac & Cardiovascular Systems
Gilberto Campos Guimaraes Filho, Priscila Valverde de Oliveira Vitorino, Sayuri Inuzuka, Adriana Sebba Barroso, Robson Pierre Pacifico Alves Filho, Victoria Alves Melo, Luiz Fernando de Oliveira Urzeda, Ana Luiza Lima Sousa, Antonio Coca, Paulo Cesar Brandao Veiga Jardim, Weimar Kunz Sebba Barroso
Summary: This study compared the parameters, arterial stiffness, target organ damage, and renal profile between central blood pressure (CBP) and peripheral blood pressure (PBP) guided hypertension treatments. The intervention guided by CBP resulted in reductions in central diastolic blood pressure and augmentation index (AIx) compared to the peripheral group (PG). Additionally, the frequency of changed pulse wave velocity (PWV) and left ventricular mass index (LVMI) was lower in the CBP group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Agne Laucyte-Cibulskiene, Chen-Huan Chen, John Cockroft, Pedro G. Cunha, Maryam Kavousi, Aleksandras Laucevicius, Maria Lorenza Muiesan, Ernst R. Rietzschel, Ligita Ryliskyte, Irina D. Strazhesko, Charalambos Vlachopoulos, Jorge Cotter, Ekatherina N. Dudinskaya, Nichola Gale, Fariba Ahmadizar, Francesco U. S. Mattace-Raso, Maggie Munnery, Pedro Oliveira, Anna Paini, Massimo Salvetti, Olga N. Tkacheva, Edward G. Lakatta, Peter M. Nilsson, Angelo Scuteri
Summary: This study aimed to investigate the effect of metabolic syndrome (MetS) and its components on central blood pressure (CBP). The results showed that individuals with MetS were 50% more likely to have higher CBP. Furthermore, specific clusters of MetS components were found to be associated with higher CBP, with some associations being more significant in women.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yan-Feng Zhou, Yanxiu Wang, Guodong Wang, Zhen Zhou, Shuohua Chen, Tingting Geng, Yan-Bo Zhang, Yi Wang, Jun-Xiang Chen, An Pan, Shouling Wu
Summary: This study aimed to investigate the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk. The results showed that statin use was associated with lower baseline baPWV and slower progression of baPWV.
Article
Pharmacology & Pharmacy
Yancui Sun, Ying Zhang, Fei Liu, Xiaojie Liu, Tesfaldet H. Hidru, Xiaolei Yang, Yinong Jiang
Summary: This study found that the circadian rhythm of blood pressure is associated with arterial stiffness and endothelial dysfunction in patients with essential hypertension. The results showed that baPWV was highest in the reverse dipping group, followed by the non-dipper and dipper groups. Additionally, endothelial function improved with increased nocturnal blood pressure decline. Therefore, a decrease in nighttime systolic blood pressure may be associated with endothelial function and arterial stiffness.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Medicine, General & Internal
Konstantinos Markakis, Nikolaos Pagonas, Eleni Georgianou, Panagiota Zgoura, Benjamin J. Rohn, Sebastian Bertram, Maximilian Seidel, Sebastian Bettag, Hans-Joachim Trappe, Nina Babel, Timm H. Westhoff, Felix S. Seibert
Summary: The study found that in patients with shock, both oscillometric blood pressure monitoring devices were successful in completing hemodynamic assessments, but there were significant differences between invasive and non-invasive techniques. There were discrepancies in pulse wave velocity measurements between the two devices. Non-invasive peripheral blood pressure measurement may not always be successful in certain circumstances.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Kim Phan, Ian Schiller, Nandini Dendukuri, Yessica-Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella S. Daskalopoulou
Summary: The study found that pregnant women who developed PrE showed alterations in arterial stiffness and wave reflection parameters in the early second trimester, while those who did not develop PrE did not exhibit these changes. This suggests the potential clinical utility of arterial stiffness and wave reflection parameters as an early screening tool for PrE to inform clinical management of high-risk pregnancies.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
Rumyana Dimova, Nevena Chakarova, Giuseppe Daniele, Cristina Bianchi, Angela Dardano, Stefano Del Prato, Tsvetalina Tankova
Summary: This study aimed to assess the relationship between insulin secretion and sensitivity, and daily glucose variability (GV) in the early stages of dysglycemia. The results showed that impairment of glucose tolerance was associated with worsening GV, and the increase in GV was inversely related to insulin secretion and action.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Monia Garofolo, Vinicio Napoli, Daniela Lucchesi, Sandra Accogli, Maria Letizia Mazzeo, Piercarlo Rossi, Emanuele Neri, Stefano Del Prato, Giuseppe Penno
Summary: The study explores the role of kidney ultrasonography in differentiating diabetic kidney disease (DKD) phenotypes in type 2 diabetes patients, showing that there are differences in morphological and vascular properties among different DKD phenotypes. The findings suggest the potential of imaging techniques in better characterizing DKD phenotypes in clinical practice.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Endocrinology & Metabolism
Chantal Mathieu, Stefano Del Prato
Editorial Material
Endocrinology & Metabolism
Chantal Mathieu, Jeannette Soderberg, Stefano Del Prato, Anne-Marie Felton, Xavier Cos, Carine de Beaufort, Jean-Francois Gautier, Bastian Hauck, Angus Forbes, Robert Heine, Peter Schwarz, Bart Torbeyns
Article
Neurosciences
Silvia Animali, Cecilia Steinwurzel, Angela Dardano, Veronica Sancho-Bornez, Stefano Del Prato, Maria Concetta Morrone, Giuseppe Daniele, Paola Binda
Summary: Brain function is affected by metabolic changes and obesity, but little is known about the impact of transient metabolic changes on brain plasticity. In this study, researchers investigated the effect of fasting and fed states on ocular dominance plasticity following short-term monocular deprivation. They also examined the correlation between plasticity changes and variations in glucose metabolism, leptin signaling, and fatty acid metabolism. The results showed that fasting reduced the manifestation of short-term plasticity compared to the fed state, and GLP-1 infusion did not have reliable effects. The reduction in plasticity during fasting was associated with an increase in plasma beta-hydroxybutyrate levels, suggesting a link between neural function and alternative energy substrates. These findings reveal a previously unexplored connection between homeostatic brain plasticity and the physiological changes associated with the daily fast-fed cycle.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Tadej Battelino, Charles M. Alexander, Stephanie A. Amiel, Guillermo Arreaza-Rubin, Roy W. Beck, Richard M. Bergenstal, Bruce A. Buckingham, James Carroll, Antonio Ceriello, Elaine Chow, Pratik Choudhary, Kelly Close, Thomas Danne, Sanjoy Dutta, Robert Gabbay, Satish Garg, Julie Heverly, Irl B. Hirsch, Tina Kader, Julia Kenney, Boris Kovatchev, Lori Laffel, David Maahs, Chantal Mathieu, Didac Mauricio, Revital Nimri, Rimei Nishimura, Mauro Scharf, Stefano Del Prato, Eric Renard, Julio Rosenstock, Banshi Saboo, Kohjiro Ueki, Guillermo E. Umpierrez, Stuart A. Weinzimer, Moshe Phillip
Summary: Randomised controlled trials and other prospective clinical studies have traditionally used HbA1c as a measure of average blood glucose levels, but with the increasing use of continuous glucose monitoring (CGM), CGM-derived metrics are being considered for use in these studies. This consensus statement recommends the use of CGM data in clinical studies to provide additional clinical information beyond HbA1c. Standardizing the collection and reporting of CGM data in clinical trials can enhance the interpretability of the data and inform therapeutic decisions related to hypoglycaemia, postprandial hyperglycaemia, and glucose variability.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hertzel C. Gerstein, Zhuoru Li, Chinthanie Ramasundarahettige, Seungjae Baek, Kelley R. H. Branch, Stefano Del Prato, Carolyn S. P. Lam, Renato D. Lopes, Richard Pratley, Julio Rosenstock, Naveed Sattar
Summary: In the AMPLITUDE-O trial, adding either 4 mg or 6 mg weekly of efpeglenatide reduced major adverse cardiovascular events in people with type 2 diabetes. The benefits of efpeglenatide appear to be dose-related.
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Anna Solini, Domenico Trico, Stefano Del Prato
Summary: Major cardiovascular outcome trials and real-life observations have shown that GLP-1 receptor agonists (GLP-1RAs) provide clinically relevant cardiovascular protection regardless of GLP-1 homology. GLP-1RAs offer cardioprotective benefits through various mechanisms, including improved insulin secretion and action, weight loss, reduced blood pressure, improved lipid profile, as well as direct effects on the heart and vasculature. The available evidence has led professional and medical societies to recommend GLP-1RAs for reducing cardiovascular risk in people with type 2 diabetes.
Article
Plant Sciences
Nafiou Arouna, Morena Gabriele, Elena Tomassi, Laura Pucci
Summary: African locust bean seeds are essential in the diet and health of Western African populations. Fermentation increases the polyphenol content and antioxidant activity of the seeds, while both fermented and non-fermented seeds exhibit antihypertensive effects.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Cell Biology
Rosario Amato, Alberto Melecchi, Laura Pucci, Alessio Canovai, Silvia Marracci, Maurizio Cammalleri, Massimo Dal Monte, Carla Caddeo, Giovanni Casini
Summary: Encapsulating Lisosan G (LG) in liposomes can enhance its protective effects against diabetic retinopathy-induced damage to the retina.
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Francesca Nicoli, Fabrizia Citro, Annamaria Ciccarone, Monia Garofolo, Stefano Del Prato, Cristina Bianchi
Summary: The study aimed to evaluate the impact of adding a GLP-1 RA in individuals with T2D on a BB insulin regimen. The results showed that HbA1c and body weight significantly decreased at 6 months after starting GLP-1 RA therapy and remained stable up to 24 months. In addition, at 24 months, a large percentage of subjects discontinued prandial and basal insulin. The findings suggest that replacing prandial insulin with GLP-1 RA is a valuable strategy to simplify the BB insulin regimen, improve glycemic control, and promote weight loss in people with T2D.
ACTA DIABETOLOGICA
(2023)
Article
Food Science & Technology
Elena Tomassi, Daniela Lucchesi, Carla Caddeo, Donatella Valenti, Veronica Sancho, Ramon Pons, Laura Pucci
Summary: Research has shown that liposomes can effectively address the instability, low solubility, and poor absorption of compounds such as polyphenols, polyunsaturated fatty acids, vitamins, and alpha-lipoic acid in therapy. They provide protection from physiological degradation and offer a safe method of application to cells.
Meeting Abstract
Endocrinology & Metabolism
M. Garofolo, V. Napoli, D. Lucchesi, S. Accogli, M. Mazzeo, P. Rossi, P. Falcetta, M. Giambalvo, E. Neri, G. Penno, S. Del Prato