Article
Cardiac & Cardiovascular Systems
Pierre Boutouyrie, Phil Chowienczyk, Jay D. Humphrey, Gary F. Mitchell
Summary: Arterial stiffness is a key marker of risk in hypertension, and can be measured at material or structural levels. Studies have shown that structural stiffness predicts outcomes, with elastic arteries being most sensitive to blood pressure and age. Stiffness is considered an index of vascular aging and affects brain, kidneys, and heart function. Reduction of stiffness through antihypertensive treatments and preventive drugs may have additional benefits beyond lowering blood pressure. Newer anti-inflammatory drugs also have effects on stiffness independent of blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Hirofumi Tomiyama, Takumi Imai, Kazuki Shiina, Yukihito Higashi, Hiroki Nakano, Takamichi Takahashi, Masatsune Fujii, Chisa Matsumoto, Akira Yamashina, Taishiro Chikamori
Summary: This study examines the association of cardiovascular risk factors (CVRFs) with the rate of progression of arterial stiffness based on long-term repeated measurements. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were found to be independently associated with a fast progression of arterial stiffness, while lower values in certain biomarkers were associated with a slow progression. The findings highlight the importance of early interventions to control CVRFs in maintaining arterial health.
Article
Peripheral Vascular Disease
Keeron Stone, Simon Fryer, James Faulkner, Michelle L. Meyer, Kevin Heffernan, Anna Kucharska-Newton, Gabriel Zieff, Craig Paterson, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner
Summary: The study found no significant relationship between aortic-femoral arterial stiffness gradient (af-SG) and mean arterial pressure (MAP) in healthy older adults, as well as adults with hypertension and diabetes, indicating that af-SG may be considered as a MAP independent index of arterial health and cardiovascular disease (CVD) risk in older adults.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Michelle A. -K. Renlund, Tiina J. Jaaskelainen, Anni S. E. Kivela, Seppo T. Heinonen, Hannele M. Laivuori, Taisto A. Sarkola
Summary: This study found that children with preeclampsia develop alterations in blood pressure and arterial stiffness early in life, which are associated with gestational, perinatal, and child cardiovascular risk factors. The changes in blood pressure are related to maternal gestational blood pressure and prematurity, while arterial stiffness is determined by child characteristics.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Jesus D. Melgarejo, Wen-Yi Yang, Lutgarde Thijs, Yan Li, Kei Asayama, Tine W. Hansen, Fang-Fei Wei, Masahiro Kikuya, Takayoshi Ohkubo, Eamon Dolan, Katarzyna Stolarz-Skrzypek, Qi-Fang Huang, Valerie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Lars Lind, Edgardo Sandoya, Jan Filipovsky, Natasza Gilis-Malinowska, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Jose Boggia, Ji-Guang Wang, Yutaka Imai, Thomas Vanassche, Peter Verhamme, Stefan Janssens, Eoin O'Brien, Gladys E. Maestre, Jan A. Staessen, Zhen-Yu Zhang
Summary: This study found a close association between 24-hour mean arterial pressure and major adverse cardiovascular events, with higher 24-hour systolic blood pressure increasing risk and higher 24-hour diastolic blood pressure reducing risk. Using thresholds for 24-hour mean arterial pressure in conjunction with systolic and diastolic blood pressure can refine risk estimates.
Article
Cardiac & Cardiovascular Systems
Lin Jin, Mengjiao Zhang, Lei Sha, Mengmeng Cao, Lanyue Tong, Qingqing Chen, Cuiqin Shen, Lianfang Du, Liping Liu, Zhaojun Li
Summary: This study explores the use of the non-invasive arterial stiffness index (API) as a marker for residual stress in the peripheral muscular arteries in clinical settings, and investigates its association with cardiovascular disease (CVD) risk in China. The results show a U-shaped association between API and the China-PAR score, suggesting that API may play an important role in predicting CVD risk in the Chinese population.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Yu-Tsung Chou, Hung-Yu Chen, Wei-Chen Shen, I-Hsuan Wu, Fei-Lin Su, Wen-Huang Lee, Hung-Lung Hsu, Jui-Ting Tai, Chung-Yi Li, Ting-Hsing Chao
Summary: High blood pressure indices are positively associated with arterial stiffness, and in normotensive individuals, systolic blood pressure and mean arterial pressure exhibit a more prominent relationship with arterial stiffness.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Frederick K. Ho, Stuart R. Gray, Paul Welsh, Jason M. R. Gill, Naveed Sattar, Jill P. Pell, Carlos Celis-Morales
Summary: This study explores the differences in cardiovascular disease (CVD) risk and associated factors among South Asian, Black, and White individuals. The results suggest that adiposity is an important risk factor for CVD regardless of ethnicity. Targeting interventions based on different risk profiles may be the most effective approach to address ethnic inequalities in CVD incidence.
Article
Cardiac & Cardiovascular Systems
Rayan Anbar, Nish Chaturvedi, Sophie V. Eastwood, Therese Tillin, Alun D. Hughes
Summary: The risk of coronary heart disease and stroke in South Asian people in the UK is higher than that in Europeans, while African Caribbean people have a lower risk of coronary heart disease but a higher risk of stroke. Differences in carotid atherosclerosis among ethnic groups were found, which can be partially explained by ASCVD risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Stephanie Pan, Vanessa Xanthakis, Alexa Beiser, Martin G. Larson, Sudha Seshadri, Gary F. Mitchell
Summary: This study examines the association between arterial stiffness and various health outcomes, including hypertension, diabetes, chronic kidney disease, dementia, cardiovascular disease, coronary heart disease, stroke, and death. The results show that arterial stiffness is associated with an increased risk of these health outcomes.
Article
Medicine, Research & Experimental
Vladiana Turi, Stela Iurciuc, Octavian Marius Cretu, Delia Mirela Tit, Simona Bungau, Adrian Apostol, Radu Dumitru Moleriu, Cristiana Bustea, Tapan Behl, Camelia Cristina Diaconu, Izabella Petre
Summary: The study revealed significant differences in hemodynamic and arterial stiffness parameters as well as heart rate between pregnant women with hypertension and those without. Arterial function parameters in women with pregnancy-induced hypertension differed long before the onset of high blood pressure, and body mass index had a deleterious effect, especially in pregnant women with hypertension. The assessment of arterial function parameters and BMI is important for predicting future blood pressure values and outcomes during pregnancy.
Article
Peripheral Vascular Disease
Lin Jin, Jianxiong Chen, Mengjiao Zhang, Lei Sha, Mengmeng Cao, Lanyue Tong, Qingqing Chen, Cuiqin Shen, Lianfang Du, Zhaojun Li, Liping Liu
Summary: This study included 4,311 participants aged 20 to 79 years and found that uncontrolled hypertension is associated with increased arterial stiffness and central artery pressure, which are important predictors of cardiovascular disease risk.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Li-Wei Wu, Te OuYoung, Yu-Chih Chiu, Ho-Feng Hsieh, Hsin Hsiu
Summary: This study aimed to determine the effects of sarcopenia on pulse waveform and develop discriminating models for possible sarcopenia using noninvasive pulse measurements, frequency-domain analysis, and machine learning. The results showed significant differences in spectral indices of the blood pressure waveform between subjects with possible sarcopenia and robust individuals. The developed machine learning and scoring system exhibited excellent discrimination performance.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Yi Ying Ong, Mya-Thway Tint, Izzuddin M. Aris, Wen Lun Yuan, Ling-Wei Chen, Marielle Fortier, Jonathan Choo, Lieng Hsi Ling, Lynette Shek, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Mary F-F Chong, Shiao-Yng Chan, Johan G. Eriksson, Mary E. Wlodek, Emanuella De Lucia Rolfe, Ken K. Ong, Navin Michael, Yung Seng Lee
Summary: This study examined the relationship between birthweight components and childhood cardiovascular risk. The findings suggest that low adiposity at birth is associated with increased childhood blood pressure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Kartik Gupta, Mahmoud Al Rifai, Aliza Hussain, Abdul Mannan Khan Minhas, Jaideep Patel, Dinesh Kalra, Zainab Samad, Salim S. Virani
Summary: South Asians, accounting for approximately 25% of the global population, are the fastest-growing ethnicity in the US. This population faces an increasing burden of atherosclerotic cardiovascular disease (ASCVD), with current risk prediction equations underestimating their risk.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)