期刊
ORGANIC LETTERS
卷 17, 期 17, 页码 4248-4251出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02039
关键词
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资金
- National Health Research Institutes
- Ministry of Science and Technology of Taiwan [MOST-103-2113-M-400-002-MY3]
Making use of the Hauser-Kraus annulation as a key step, the first total synthesis of tetarimycin A has been accomplished in a highly convergent and operationally simple manner. Preliminary SAR not only validated that tetarimycin A exhibited potent activity against MRSA and VRE at a low MIC value but also identified that the hydroxyl group at C-10 was essential for antibacterial activities.
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