期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 12, 页码 3585-3588出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00183h
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资金
- DST, SERB, India [SB/FT/CS-54/2011]
- Council of Scientific and Industrial Research (CSIR), New Delhi
A straightforward and unified strategy to access Amaryllidaceae alkaloids comprising a cis-3a-aryloctahydroindole scaffold has been developed. The strategy features Eschenmoser-Claisen rearrangement of allylalcohol as a key step for the installation of all-carbon quaternary stereocenters present in these alkaloids. The consequent iodolactonization-reduction-oxidation sequence beautifully assembles the advanced intermediate keto-aldehyde 10a, b in synthetically viable yields. The methodology has been successfully applied in the efficient syntheses of (+/-)-mesembrane (1a) and (+/-)-crinane (2a).
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