Cu(I)/TF-BiphamPhos-catalyzed asymmetric Michael addition of cyclic ketimino esters to alkylidene malonates

Cu(I)-catalyzed asymmetric Michael addition of cyclic ketimino esters with alkylidene malonates has been developed for efficient construction of beta-branched alpha-amino acids containing adjacent quaternary and tertiary stereogenic centers in good yields with excellent diastereo-/enantioselectivities. The generated Michael adduct was further converted to the biologically important pyrrolizidine analogues via one-pot sequential reduction/lactamization.