Article
Chemistry, Multidisciplinary
Lingxiu Liu, Chunbin Li, Jianye Gong, Ying Zhang, Weiwei Ji, Lina Feng, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang
Summary: By utilizing the distinctive structural characteristics of anion-p(+) interactions, a highly water-soluble type I photosensitizer (DPBC-Br) with aggregation-induced emission (AIE) and near-infrared (NIR) emission is developed. DPBC-Br displays remarkable water solubility, outstanding photobleaching resistance, and enables efficient differentiation between tumor cells and normal cells via NIR-I imaging. Additionally, DPBC-Br produces superior type I reactive oxygen species (ROS), showing specific killing of cancer cells and inhibition of tumor growth with negligible systemic toxicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Xuehong Min, Fan Yi, Xiao-Le Han, Ming Li, Qianci Gao, Xiaocui Liang, Zhao Chen, Yue Sun, Yi Liu
Summary: This study presents an effective synthetic strategy for preparing water-soluble AIE photosensitizers with high targeted capacity mediated by supramolecular assembly. The reversible control of singlet oxygen generation and photodynamic targeting of cancer cells in an acidic environment is achieved.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Nanoscience & Nanotechnology
Jincong Yan, Tian Gao, Zhongzhong Lu, Jingbo Yin, Ye Zhang, Renjun Pei
Summary: Aptamers, short oligonucleotide sequences with selective binding abilities, have shown promise in improving controlled and accurate delivery of photosensitizers into tumor sites for enhanced photodynamic therapy. Modification of aptamers onto PSs or nanocarriers enables specific recognition and binding to tumor cells, resulting in superior therapeutic efficiency. The development of aptamer-targeted platforms for tumor therapy holds potential for synergistic treatment modalities like PDT, photothermal therapy, and chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Kaiwu Yu, Jiayue Pan, Mei Tian, Haoke Zhang, Chentao Jin, Hong Zhang, Zhengwei Mao, Qinggang He
Summary: Photodynamic therapy (PDT) is a promising anticancer treatment strategy. Researchers have developed a mitochondria-targeted photosensitizer with aggregation-induced emission (AIE) characteristics, which exhibits high fluorescence efficiency and photostability. The photosensitizer efficiently binds to 4T1 breast cancer cells and induces cell death through the apoptotic pathway under white light irradiation, demonstrating its potential application in cancer imaging and PDT.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Medicine, Research & Experimental
Han Sun, Ruihua Guo, Yanhui Guo, Jitao Song, Zhiliang Li, Fengling Song
Summary: Porphyrins have been widely used in photodynamic therapy for cancer treatment, but their poor water solubility, self-quenching on ROS generation, and low tolerance for hypoxic conditions hinder their therapeutic efficacy. In this study, a water-soluble porphyrin with cationic side chains was developed, which exhibited enhanced ROS generation and effective tumor ablation capability. This research demonstrates the potential of side-chain chemistry in improving the photodynamic properties of porphyrins for cancer therapy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Kyeongsoon Park, Jae Won Ahn, Jin Hyuk Kim, Jin Won Kim
Summary: In this study, researchers fabricated a dextran sulfate-based nano-photosensitizer (DS-Ce6) to specifically target M2-like tumor-associated macrophages (TAMs) for enhanced photodynamic therapy (PDT). The nano-photosensitizer showed selective uptake by M2 macrophages and induced tumor cell apoptosis under laser irradiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, Research & Experimental
Tingting Hu, Zhengdi Wang, Weicheng Shen, Ruizheng Liang, Dan Yan, Min Wei
Summary: Photodynamic therapy (PDT) is a non-invasive therapeutic modality that has gained attention for its high selectivity and limited side effects. However, limitations such as inadequate light penetration depth and non-targeting photosensitizers have hindered its full clinical application. Current research focuses on innovative strategies to overcome these limitations and enhance the therapeutic effect of PDT.
Article
Chemistry, Medicinal
Elif Yildiz Gul, Elanur Aydin Karatas, Hatice Aydin Dogan, Omer Faruk Karatas, Buenyemin Cosut, Esra Tanriverdi Ecik
Summary: In this study, smart photosensitizers containing BODIPY, erlotinib, and hydrophilic units were prepared and their physicochemical properties and PDT effects were investigated. The halogenated derivatives showed lower fluorescence and good ROS generation ability under red light. In vitro experiments demonstrated the potent activity of the halogenated conjugates on cancer cell viability and their low dark toxicity.
Review
Chemistry, Inorganic & Nuclear
Jianjun Du, Tiancong Shi, Saran Long, Pengzhong Chen, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: Photodynamic therapy (PDT) is a non-invasive therapy that has attracted increasing interest for treating tumors, but the lack of oxygen in solid tumors limits its effectiveness. The reconstruction of the tumor microenvironment and development of anti-hypoxia photosensitizers are important research topics for improving the efficacy of PDT.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Engineering, Biomedical
Huan Chen, Yingpeng Wan, Xiao Cui, Shengliang Li, Chun-Sing Lee
Summary: The review summarizes recent progress on AIE PSs in overcoming tumor hypoxia, highlighting the practical molecular principles and classifying cases into low O2-dependent and O2-dependent strategies. Challenges and prospects in hypoxia-overcoming PDT using AIE PSs are discussed, aiming to drive further development in the field.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Lei Chen, Jiahui Huang, Xiaotong Li, Miaoting Huang, Shaoting Zeng, Jiayi Zheng, Shuyi Peng, Shiying Li
Summary: Photodynamic therapy (PDT) is an advanced therapeutic strategy that has been widely used in the clinical treatment of solid tumors. Various strategies, including improving photosensitizers delivery and tumor microenvironment, as well as synergistic treatment with other therapies, have been investigated to enhance the efficacy of PDT.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Qing Yu, Xia Li, Juan Wang, Lanping Guo, Wenyuan Gao, Luqi Huang
Summary: Photodynamic therapy (PDT) is a potential tumor therapy that is specific in time and space and has non-invasive advantages. However, there are still challenges in its practical application, such as tumor hypoxia and immunosuppressive microenvironment. Reprogramming the tumor microenvironment is significant for rejuvenating PDT.
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)