☆ 4.6 Article

Rhodium-catalyzed asymmetric addition of arylboronic acids to cyclic N-sulfonyl ketimines towards the synthesis of α,α-diaryl-α-amino acid derivatives

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY

卷 13, 期 17, 页码 4918-4924

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ROYAL SOC CHEMISTRY

DOI: 10.1039/c5ob00431d

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Chemistry, Organic

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MEXT, Japan
Grants-in-Aid for Scientific Research [24550117, 25105730] Funding Source: KAKEN

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摘要

Rhodium/chiral diene complex-catalyzed asymmetric addition of arylboronic acids to cyclic ketimines having an ester group proceeded to give the corresponding alpha-amino acid derivatives in high yields with high enantioselectivity. The cyclic amino acid derivative was transformed into a linear alpha,alpha-diaryl-substituted alpha-N-methylamino acid ester.

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