期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 45, 页码 10968-10972出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob01895a
关键词
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资金
- 973 program [2015CB856600]
- NSFC [21222204, 21472049]
Ph-3 PAuOTf is identified as a powerful catalyst for the addition of difluoroenol silyl ethers to N-Boc isatin ketimines and other two kinds of active cyclic ketimines. This represents the first Au(I)catalyzed Mukaiyama-Mannich reaction, and the corresponding non-fluorinated enol silyl ether proves to be even much more reactive under the same conditions. This method paves the way to the total synthesis of difluoromethylated analogues of AG-041R, a gastrin/CCK-B receptor antagonist.
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