☆ 4.6 Article

Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 21, 页码 6073-6081

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00780a

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Chemistry, Organic

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  1. Natural Sciences and Engineering Research Council of Canada (NSERC)
  2. Alberta Innovates Health Solutions (AIHS)
  3. Canada Research Chair in Bioorganic and Medicinal Chemistry

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Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B-1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B-1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

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