Article
Nursing
Hande Z. Ulus, Merve Yasemin Tekbudak, Jonathan C. Allen
Summary: The research aimed to concentrate human milk in a milk bank setting by precipitating lactose, in order to increase its caloric and protein density while avoiding the side effects of high osmolality. The results showed that lactose and osmolality were significantly reduced in the concentrated milk without significant protein loss. This method could potentially provide a simple and low-cost solution for feeding preterm infants with higher nutrient density and no non-human components.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Nutrition & Dietetics
Jean-Christophe Roze, Mickael Hartweg, Laure Simon, Helene Billard, Yipu Chen, Sean Austin, Cecile Boscher, Thomas Moyon, Dominique Darmaun, Clara L. Garcia Rodenas, Clair-Yves Boquien
Summary: This study explored the impact of HMOs on growth and neurodevelopment in preterm infants. The findings showed that HMO concentrations decreased with advancing postnatal age. Total HMOs were positively correlated with neonatal length growth. Among Secretor(+) Lewis(+) mothers, LNFP-III was significantly associated with neurodevelopmental scores at 2 years.
CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Safiyyah Abbas, Amy K. Keir, Maria Makrides, Laura D. Klein, Luke E. Grzeskowiak, Andrew J. McPhee, Alice R. Rumbold
Summary: NEC is a devastating disease affecting preterm infants, and HMOs are emerging as a potential preventive therapy. However, there are challenges in tailoring HMO delivery to preterm infants and further research is needed to understand the benefits and long-term effects of oligosaccharide supplementation.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Reka A. Vass, Gabriella Kiss, Edward F. Bell, Robert D. Roghair, Attila Miseta, Jozsef Bodis, Simone Funke, Tibor Ertl
Summary: Pituitary hormones like prolactin and luteinizing hormone were found to be higher in breast milk from mothers of preterm infants compared to term infants. Infant formulas have higher total protein content but do not contain detectable levels of pituitary hormones.
Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Article
Microbiology
Lynn E. Ferro, Kameron Y. Sugino, Vanja Klepac-Ceraj, Sarah S. Comstock
Summary: This study reported the abundance and prevalence of HMO-metabolizing genes in fecal samples from human infants, finding that certain genes were more abundant in infants fed human milk, while others tended to be less abundant with a higher intake of solid foods. The study showed a positive association between human milk exposure and certain gene abundance.
Review
Food Science & Technology
Jimena Rios, Viviana Valero-Jara, Samanta Thomas-Valdes
Summary: Exclusive breastfeeding is recommended during the first 6 months of life, with breast milk composition being influenced by maternal diet. Polyphenols and carotenoids present in breast milk have antioxidant activities and potential benefits for infants, with their content depending on maternal intake and various factors. Further research is needed to understand the relationship between these phytochemicals and development of infants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
David A. Mills, J. Bruce German, Carlito B. Lebrilla, Mark A. Underwood
Summary: For more than 100 years, doctors have observed the presence of bifidobacteria in the feces of breast-fed infants, which has been linked to their health. Recent advancements in genomics and glycomics have helped explain this enrichment and allowed for the targeted use of probiotics to restore bifidobacterial functions in at-risk infants. This review highlights two decades of research that has paved the way for the use of bifidobacteria in the intestines of at-risk newborns, and proposes a model for measuring probiotic efficacy in improving infant health based on metabolic outcomes.
Article
Nursing
Katherine R. Standish, Ginny Combs, Marcy Mcmahon, Cheryl Slater, Lisa Zani, Christina Pindar, Karol Serafin, Margaret G. Parker, Barbara L. Philipp
Summary: Late preterm infants have lower breastfeeding rates and there are few interventions or guidelines for managing them in non-intensive nursery settings. This study developed and implemented an interdisciplinary breastfeeding support program, which increased nurses' attentiveness and confidence in caring for late preterm infants. However, well-designed clinical studies are needed to identify effective breastfeeding support practices.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Nutrition & Dietetics
Agnieszka Bzikowska-Jura, Natalia Machaj, Piotr Sobieraj, Olga Barbarska, Gabriela Oledzka, Aleksandra Wesolowska
Summary: The primary aim of the study was to evaluate the variability in macronutrient content of donor human milk and investigate the impact of maternal factors and feeding practices. Results showed no significant differences in energy and macronutrient content of the milk, although fat concentration was positively correlated with afternoon feedings. The method of feeding did not affect the nutritional value of the milk.
Article
Chemistry, Applied
Chuncui Huang, Yue Lu, Lin Kong, Zhendong Guo, Keli Zhao, Zheng Xiang, Xinyue Ma, Huanyu Gao, Yongfang Liu, Zhongmin Gao, Lijuan Xu, Wengang Chai, Yan Li, Yao Zhao
Summary: Human milk oligosaccharides (HMOs) are important for protecting infants from infections, especially for preterm infants. However, there is limited research on the specific differences in HMOs as a function of gestation time. In this study, we established an approach to analyze HMOs and found that the composition and relative abundance of HMOs changed with postpartum age, with significant differences in HMOs secreted at different postpartum times.
CARBOHYDRATE POLYMERS
(2023)
Review
Nutrition & Dietetics
Paige K. Berger, Margaret L. Ong, Lars Bode, Mandy B. Belfort
Summary: The objective of this review was to analyze the literature on HMOs and neurodevelopmental outcomes in human milk-fed infants. Six studies were identified, all observational in design, and five conducted in full-term infants. The studies found that HMOs were positively associated with cognitive, language, and motor skill domains in infants between 18 and 24 months of age.
Article
Nursing
Chara Biggs
Summary: This study investigated the reasons why mothers in South Africa who had committed to donating to a human milk bank did not donate their milk. The major barriers identified were ignorance of the post-discharge process and lack of support from clinic staff, as well as practical challenges such as transportation issues and maintaining the cold chain. Potential solutions include mothers donating milk only at clinic immunization visits.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Medicine, General & Internal
Afif El-Khuffash, Adam J. Lewandowski, Amish Jain, Aaron Hamvas, Gautam K. Singh, Philip T. Levy
Summary: This study found that preterm infants with higher consumption of mother's own milk had enhanced cardiac performance at age 1 year, suggesting a favorable association between consumption of maternal breast milk and cardiac performance in preterm infants.
Review
Immunology
Gatien A. G. Lokossou, Leonce Kouakanou, Anne Schumacher, Ana C. Zenclussen
Summary: Breastfeeding has long-term benefits for both children and mothers, reducing the risks of infectious and non-communicable diseases. The components in breast milk play important roles in disease protection and immune system development in newborns.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chloe A. Autran, Benjamin P. Kellman, Jae H. Kim, Elizabeth Asztalos, Arlin B. Blood, Erin C. Hamilton Spence, Aloka L. Patel, Jiayi Hou, Nathan E. Lewis, Lars Bode
Article
Obstetrics & Gynecology
Jae H. Kim
CLINICS IN PERINATOLOGY
(2019)
Article
Pediatrics
Ronald I. Clyman, Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Hakansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C. Hassinger, Susan W. Aucott, Madoka Hayashi, Anne Marie Heuchan, William A. Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize, Scott Fields, Lora Whitten, Stefanie Rogers, Emel Okulu, Gaffari Tunc, Tayfun Ucar, Ebru Turkoglu Unal, Jane Steen, Kathy Arnell, Sarah Holtschlag, Michael Schreiber, Caryn Peters, Maureen Gilmore, Lorna Mckay, Dianne Carole, Annette Shaw, Malinda Harris, Amy Amsbaugh, Lavonne M. Liedl, Sue Wolf, Avi Groner, Amy Kimball, Jae Kim, Renee Bridge, Ellen Knodel, Chrissy Weng, Magaly Diaz Barbosa, Richard Polin, Marilyn Weindler, Shahab Noori, Jeffrey Reese, Yao Sun
JOURNAL OF PEDIATRICS
(2019)
Article
Pediatrics
Elizabeth E. Foglia, Anne Ades, Taylor Sawyer, Kristen M. Glass, Neetu Singh, Philipp Jung, Bin Huey Quek, Lindsay C. Johnston, James Barry, Jeanne Zenge, Ahmed Moussa, Jae H. Kim, Stephen D. DeMeo, Natalie Napolitano, Vinay Nadkarni, Akira Nishisaki
Article
Health Care Sciences & Services
Hadley S. Sauers-Ford, James P. Marcin, Mark A. Underwood, Jae H. Kim, Yona Nicolau, Cherry Uy, Shelby T. Chen, Kristin R. Hoffman
TELEMEDICINE AND E-HEALTH
(2019)
Article
Pediatrics
Taylor Sawyer, Elizabeth E. Foglia, Anne Ades, Ahmed Moussa, Natalie Napolitano, Kristen Glass, Lindsay Johnston, Philipp Jung, Neetu Singh, Bin Huey Quek, James Barry, Jeanne Zenge, Stephen D. Demeo, Brianna Brei, Jeanne Krick, Jae H. Kim, Vinay Nadkarni, Akira Nishisaki
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2019)
Article
Pediatrics
Frank R. Greer, Scott H. Sicherer, A. Wesley Burks, Steven A. Abrams, George J. Fuchs, Jae H. Kim, C. Wesley Lindsey, Sheela N. Magge, Ellen S. Rome, Sarah Jane Schwarzenberg, Mark R. Corkins, Steven R. Daniels, Neville H. Golden, Janet de Jesus, Andrea Lotze, Cria Perrine, Valery Soto, Todd A. Mahr, Jordan S. Orange, Michael Pistiner, Julie Wang, Paul Williams, Chitra Dinakar, Anne-Marie Irani, Jennifer S. Kim, Debra Burrowes
Article
Pediatrics
Linda Truong, Jae H. Kim, Anup C. Katheria, Neil N. Finer, Krishelle Marc-Aurele
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2020)
Article
Obstetrics & Gynecology
Yuri Ozawa, Anne Ades, Elizabeth E. Foglia, Stephen DeMeo, James Barry, Taylor Sawyer, Neetu Singh, Kristen Glass, Philipp Jung, Bin Huey Quek, Lindsay Johnston, Jae Kim, Natalie Napolitano, Justine Shults, Vinay M. Nadkarni, Akira Nishisakil
JOURNAL OF PERINATOLOGY
(2019)
Article
Pediatrics
Aaron S. Bernstein, Emily Oken, Sarah de Ferranti, Jennifer Ann Lowry, Samantha Ahdoot, Carl R. Baum, Aaron S. Bernstein, Aparna Bole, Lori G. Byron, Philip J. Landrigan, Steven M. Marcus, Susan E. Pacheco, Adam J. Spanier, Alan D. Woolf, Steven A. Abrams, George J. Fuchs, Jae Hong Kim, C. Wesley Lindsey, Sheela Natesh Magge, Ellen S. Rome, Sarah J. Schwarzenberg
Article
Genetics & Heredity
Mikayla F. A. Baxter, Sami Dridi, Dawn A. Koltes, Juan D. Latorre, Walter G. Bottje, Elizabeth S. Greene, Stephen W. Bickler, Jae H. Kim, Ruben Merino-Guzman, Xochitl Hernandez-Velasco, Nicholas B. Anthony, Billy M. Hargis, Guillermo Tellez-Isaias
FRONTIERS IN GENETICS
(2019)
Editorial Material
Pediatrics
Michael S. Caplan, Mark A. Underwood, Neena Modi, Ravi Patel, Phillip V. Gordon, Karl G. Sylvester, Steven McElroy, Paolo Manzoni, Sheila Gephart, Walter J. Chwals, Mark A. Turner, Jonathan M. Davis, Marilee Allen, Gerri Baer, Gail Besner, Jennifer Canvasser, Hala Chaaban, Robert Clay, Eamonn Connolly, Jonathan M. Davis, Jennifer Duchon, Wakako Eklund, Joanne Ferguson, Samir Gadepalli, Misty Good, Cristal Grogan, Lynn Hudson, Minesh Khashu, Jae Kim, Andrea Lotze, Alexandra Mangili, Troy Markel, Laura Martin, Tokuo Miyazawa, Josef Neu, Gary Noel, Ron Portman, Simone Rosito, Ann Schwartz, Brian Scottoline, Suna Seo, Staffan Stromberg, William Treem, Erin Umberger, Tracy Warren, Alicia West
JOURNAL OF PEDIATRICS
(2019)
Article
Gastroenterology & Hepatology
Jenny K. Koo, Averyl Narvasa, Lars Bode, Jae H. Kim
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2019)
Article
Environmental Sciences
Cuong D Tran, Nathan G. Dodder, Penelope J. E. Quintana, Kayo Watanabe, Jae H. Kim, Melbourne F. Hovell, Christina D. Chambers, Eunha Hoh
Article
Nutrition & Dietetics
Mikayla F. A. Baxter, Juan D. Latorre, Dawn A. Koltes, Sami Dridi, Elizabeth S. Greene, Stephen W. Bickler, Jae H. Kim, Ruben Merino-Guzman, Xochitl Hernandez-Velasco, Nicholas B. Anthony, Walter G. Bottje, Billy M. Hargis, Guillermo Tellez
FRONTIERS IN NUTRITION
(2018)