期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 16, 页码 4661-4667出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00176e
关键词
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资金
- National Natural Science Foundation of China [21002124, 81172933]
- Jiangsu Provincial Natural Science Foundation of China [BK20131305]
- Fundamental Research Funds for the Central Universities [JKZD2013002]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene (NHC)-catalyzed annulation of cyclic beta-enamino esters 1 with enals 2. This methodology offers a pathway for quick and efficient construction of an indolo[2,3-a]quinolizidine skeleton which is a core structure of many natural products with diverse bioactivities.
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