期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 27, 页码 7351-7380出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00855g
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资金
- Ecole Nationale Superieure de Chimie de Montpellier
- Centre National de la Recherche Scientifique
Thanks to the beneficial effect of fluorine substitution on the pharmacokinetic properties of molecules, an ever increasing number of marketed drugs incorporate a fluorine atom into their structure. As a consequence, the synthesis of fluorinated molecules has become a very active research field. Among the numerous approaches, fluorinated enol ethers are valuable building blocks that allow the introduction of a fluoro-or difluoromethyl group through a wide variety of reactions. The present review lists different methods for their preparation and sums up their numerous synthetic applications.
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