Article
Geriatrics & Gerontology
Melanie Dani, Patricia Taraborrelli, Dimitrios Panagopoulos, Andreas Dirksen, Miriam Torocastro, Richard Sutton, Phang Boon Lim
Summary: This article discusses the baroreflex mechanism in blood pressure regulation in older people, as well as the physiological and pathological reasons for its impairment. Additionally, it explores the causes of orthostatic hypotension and supine hypertension in older individuals, along with strategies for managing these conditions.
Article
Sport Sciences
R. A. C. H. E. L. J. SKOW, G. R. A. H. A. M. M. FRASER, C. R. A. I. G. D. STEINBACK, M. A. R. G. I. E. H. DAVENPORT
Summary: This study investigated the impact of aerobic exercise during pregnancy on the sympathetic regulation of blood pressure. The results showed that exercise attenuated the rise in MSNA and the blunting of neurovascular transduction, which may partially explain the lower risk of developing gestational hypertension in active pregnant women.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Cardiac & Cardiovascular Systems
Guido Grassi, Giuseppe Mancia, Murray Esler
Summary: The overdrive of the sympathetic nervous system in heart failure has been reported for over half a century. Recent advancements in methodological approaches have provided a better understanding of various aspects of neuroadrenergic alterations, including regional differences, the role of the central nervous system, and the involvement of reflex mechanisms. Additionally, the impact of sympathetic activation on cardiovascular organs and potential therapeutic interventions have been highlighted.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Kevin Ibeas, Laura Herrero, Paula Mera, Dolors Serra
Summary: Physical inactivity leads to various diseases, while regular exercise can mitigate these problems and have positive effects on cognitive function and memory. The hypothalamus responds to exercise by modulating energy metabolism through the sympathetic nervous system and catecholamine secretion. Skeletal muscle remodels during exercise training and interacts with other organs through the release of myokines into circulation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Neurosciences
Andrea Haas, David Borsook, Gail Adler, Roy Freeman
Summary: Stress can be classified as either psychosocial or physiologic. This review focuses on hypoglycemia as a model to investigate physiological stress and its consequences. Hypoglycemia is an ideal model that evokes autonomic, neuroendocrine, and immune responses.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2022)
Review
Neurosciences
Julia Forstenpointner, Igor Elman, Roy Freeman, David Borsook
Summary: This article introduces the composition and functions of the autonomic nervous system (ANS) and describes its role in stress and maladaptation. By studying the neuroanatomy of the ANS, a model is proposed to understand its importance in maintaining health and causing diseases.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Edgar Toschi-Dias, Nicola Montano, Eleonora Tobaldini, Patricia F. Trevizan, Raphaela Groehs, Ligia M. Antunes-Correa, Thais S. Nobre, Denise M. Lobo, Allan R. K. Sales, Linda M. Ueno-Pardi, Luciana D. N. J. de Matos, Patricia A. Oliveira, Ana Maria F. W. Braga, Maria Janieire N. N. Alves, Carlos E. Negrao, Maria Urbana P. B. Rondon
Summary: The study found a direct association between LFMSNA/HFMSNA and sympathetic baroreflex function, as well as muscle sympathetic nerve activity in HFrEF patients. Patients with lower LFMSNA/HFMSNA exhibited reduced cardiac function and higher heart rate compared to those with higher LFMSNA/HFMSNA.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Michael F. La Fountaine, Asante N. Hohn, Caroline L. Leahy, Anthony J. Testa, Joseph P. Weir
Summary: This study found that after 48 hours of concussion, patients had significantly lower Mayer wave activity compared to controls, which returned to normal levels by 1 week post-injury. Additionally, early after concussion, attenuated sympathetic vasomotor tone was present as the main manifestation of autonomic dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Neurosciences
M. Meusel, J. Voss, A. Krapalis, F. Machleidt, R. Vonthein, M. Hallschmid, F. Sayk
Summary: This study investigated the effects of intranasal administration of orexin A on vascular sympathetic baroreflex function in healthy humans. The results showed that intranasal orexin A increased sympathetic activity without affecting blood pressure, heart rate, or sympathovagal balance.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Hiroyuki Kinoshita, Keita Saku, Jumpei Mano, Hiroshi Mannoji, Shigehiko Kanaya, Kenji Sunagawa
Summary: Resting very short-term blood pressure variability is correlated with nocturnal blood pressure variability, and may serve as a predictor for nocturnal blood pressure variability.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Hiroyuki Kinoshita, Keita Saku, Jumpei Mano, Hiroshi Mannoji, Shigehiko Kanaya, Kenji Sunagawa
Summary: This study suggests that very short-term blood pressure variability at rest may predict nocturnal blood pressure variability. This finding has the potential to develop a novel index of blood pressure variability.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Yuhong Wang, Wanli Jiang, Hu Chen, Huixin Zhou, Zhihao Liu, Zihan Liu, Zhihao Liu, Yuyang Zhou, Xiaoya Zhou, Lilei Yu, Hong Jiang
Summary: Circadian disruption may facilitate cardiac remodeling after myocardial infarction by activating the sympathetic nervous system, leading to reduced cardiac function, increased left ventricular volume, and exacerbated cardiac fibrosis. Modulating sympathetic activity through designer receptors exclusively activated by designer drugs technique can alleviate the disruption-related cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mark B. B. Badrov, Daniel A. A. Keir, George Tomlinson, Catherine F. F. Notarius, Philip J. J. Millar, Derek S. S. Kimmerly, J. Kevin Shoemaker, Evan Keys, John S. S. Floras
Summary: This study compared patients with heart failure and healthy controls to identify factors that contribute to augmented muscle sympathetic nerve activity. The results showed that in heart failure patients, muscle sympathetic nerve activity was proportional to heart rate and body mass index, but not related to age, blood pressure, or drug therapy. This study has important implications for personalized therapy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Physiology
M. Meusel, M. Herrmann, F. Machleidt, K. Franzen, R. Vonthein, F. Sayk
Summary: Oxytocin is involved in the neuroendocrine regulation of sympathetic blood pressure homeostasis, with intranasal administration inducing vasoconstrictory sympathoactivation and an increase in diastolic blood pressure in healthy males. This suggests a potential oxytocin-mediated impact on the vascular baroreflex set point in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Neurosciences
Pei-Chi Yang, Adam Rose, Kevin R. DeMarco, John R. D. Dawson, Yanxiao Han, Mao-Tsuen Jeng, Robert D. Harvey, L. Fernando Santana, Crystal M. Ripplinger, Igor Vorobyov, Timothy J. Lewis, Colleen E. Clancy
Summary: Cardiac function is regulated by the autonomic nervous system (ANS), with sympathetic activation increasing cardiac output and parasympathetic stimulation slowing heart rate. Imbalance in autonomic control can lead to arrhythmias and heart failure. A multiscale neurocardiac model and simulator tool predicts the effect of ANS stimulation on the heart and can be used to study neuromodulatory therapy.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
