Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population

We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population. Normotensive individuals who visited our hospital for a yearly health checkup (n = 8157, men = 61.0% and age = 50.7 +/- 12.2 years) were enrolled in the present study. After baseline evaluation, participants were followed up for a median of 48.3 months (range 4.9-101.0 months), with the endpoint being the development of hypertension, defined as systolic blood pressure (BP) >= 140 mm Hg, diastolic BP >= 90 mm Hg or the use of antihypertensive medication. The impact of uric acid and other cardiovascular risk factors at baseline on future BP and development of hypertension was assessed. During follow-up, 19.0% of women (n = 605) and 29.5% of men (n = 1469) participants developed hypertension. Incident hypertension was increased across the quartiles for baseline uric acid levels (P < 0.0001), and multivariate Cox proportional hazards analysis revealed a significant and independent association between the uric acid level and the onset of hypertension in both men and women participants (P < 0.05). Furthermore, uric acid was independently and positively correlated with future BP (P < 0.05). Thus, uric acid is an independent predictor of new-onset hypertension in both women and men.