期刊
JOURNAL OF HUMAN HYPERTENSION
卷 26, 期 8, 页码 463-475出版社
SPRINGERNATURE
DOI: 10.1038/jhh.2011.66
关键词
sympathetic nerve activity; neurogenic hypertension; immune-to-brain signalling
资金
- British Heart Foundation
- National Institutes of Health [HL033610]
- Royal Society
- British Heart Foundation [PG/11/47/28980, PG/11/41/28893] Funding Source: researchfish
A neurogenic component to primary hypertension (hypertension) is now well established. Along with raised vasomotor tone and increased cardiac output, the chronic activation of the sympathetic nervous system in hypertension has a diverse range of pathophysiological consequences independent of any increase in blood pressure. This review provides a perspective on the actions and interactions of angiotensin II, inflammation and vascular dysfunction/brain hypoperfusion in the pathogenesis and progression of neurogenic hypertension. The optimisation of current treatment strategies and the exciting recent developments in the therapeutic targeting of the sympathetic nervous system to control hypertension (for example, catheter-based renal denervation and carotid baroreceptor stimulation) will be outlined. Journal of Human Hypertension (2012) 26, 463-475; doi:10.1038/jhh.2011.66; published online 7 July 2011
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