Article
Medicine, General & Internal
Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li
Summary: This study identified TYW5 as a risk gene for schizophrenia (SCZ) through a comprehensive analysis of genetic associations and brain expression data. TYW5 mRNA expression was significantly associated with SCZ risk, and TYW5 protein abundance in the brain was also linked to SCZ. Further analysis revealed elevated TYW5 expression in the brain tissues and neurons of SCZ cases compared to controls. Additionally, a genetic variant associated with higher TYW5 expression was found to be associated with specific brain structural changes. These findings provide valuable insights into the genetic mechanism of TYW5 in SCZ risk.
Article
Medicine, Research & Experimental
Lei Cai, Yanlan Sun, Yonglin Liu, Wenzhong Chen, Lin He, Dong-Qing Wei
Summary: This study identified a negative genetic correlation between T2DM and SCZ in both European and East Asian populations, with a common effective genes in the pituitary gland.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Melissa Plooster, Guendalina Rossi, Martilias S. Farrell, Jessica C. McAfee, Jessica L. Bell, Michael Ye, Graham H. Diering, Hyejung Won, Stephanie L. Gupton, Patrick Brennwald
Summary: TSNARE1, a high-confidence gene candidate for schizophrenia risk, regulates endosomal trafficking in cortical neurons and may act as an inhibitory SNARE by competing for incorporation into endosomal SNARE complex. Its localization in endosomal network and late endosomes suggests a role in negative regulation of early endosomal to late endosomal trafficking.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Duilin Liu, Lin Wu, Hui Wei, Caiyun Zhu, Runhui Tian, Wanwan Zhu, Qi Xu
Summary: This study identifies a rare variant in the SFT2D2 gene that is strongly associated with schizophrenia. The findings suggest that SFT2D2 is a novel risk gene for schizophrenia, and that elevated levels of anti-SFT2D2 IgG may contribute to the immunological aspects of schizophrenia.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Laura Ferraro, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Craig Morgan, James B. Kirkbride, Alastair G. Cardno, Pak Sham, Giada Tripoli, Lucia Sideli, Fabio Seminerio, Crocettarachele Sartorio, Andrei Szoke, Ilaria Tarricone, Miquel Bernardo, Victoria Rodriguez, Simona A. Stilo, Charlotte Gayer-Anderson, Lieuwe de Haan, Eva Velthorst, Hannah Jongsma, Rutten B. P. Bart, Alexander Richards, Celso Arango, Paulo Rossi Menezez, Antonio Lasalvia, Sarah Tosato, Andrea Tortelli, Cristina Marta Del Ben, Jean-Paul Selten, Peter B. Jones, Jim van Os, Marta Di Forti, Evangelos Vassos, Robin M. Murray
Summary: This study identified four distinct transdiagnostic clusters among first-episode psychosis patients based on their premorbid and cognitive abilities. The study also found differences in polygenic risk scores, patterns of cannabis use, and genetic predisposition to schizophrenia among these clusters.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychology, Clinical
Laura Anne Wortinger, Kjetil Nordbo Jorgensen, Claudia Barth, Stener Nerland, Runar Elle Smelror, Anja Vaskinn, Torill Ueland, Ole A. Andreassen, Ingrid Agartz
Summary: This study found that the correlation between intracranial volume and intelligence quotient was stronger in patients with schizophrenia who had experienced birth asphyxia, suggesting abnormal neurodevelopment. These findings support the use of intracranial volume and verbal intellectual abilities as clinically relevant markers for predicting schizophrenia risk.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Benedetta Seccomandi, Deborah Agbedjro, Morris Bell, Richard S. E. Keefe, Matcheri Keshavan, Silvana Galderisi, Joanna Fiszdon, Armida Mucci, Roberto Cavallaro, Margherita Bechi, Natalia Ojeda, Javier Pena, Til Wykes, Matteo Cella
Summary: The study found that current IQ plays a significant role in cognitive gains after cognitive remediation, with those with preserved IQ showing better cognitive outcomes compared to those with deteriorated or compromised IQ. This highlights the need to assess whether therapy adjustments can help lower IQ individuals derive similar benefits to those with higher IQ.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Lin Liu, Yuzhou Xue, Yangmei Chen, Tingqiao Chen, Judan Zhong, Xinyi Shao, Jin Chen
Summary: A two-sample Mendelian randomization analysis showed that acne did not have a causal impact on the risk of depression, anxiety, OCD, bipolar disorder, and PTSD. In fact, it had a mild protective effect against schizophrenia.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Lucia Sideli, Adriano Schimmenti, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Monica Aas, Luis Alameda, Eva Velthorst, Helen L. Fisher, Vincenzo Caretti, Giulia Trotta, Giada Tripoli, Diego Quattrone, Charlotte Gayer-Anderson, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Domenico Berardi, Giuseppe D'Andrea, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuan, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B. Jones, James B. Kirkbride, Pierre-Michel Llorca, Andrea Tortelli, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P. Rutten, Marta Di Forti, Craig Morgan, Robin M. Murray
Summary: Our study emphasizes the impact of childhood maltreatment on academic outcomes and cognition of individuals with first-episode psychosis and controls. Childhood maltreatment is associated with lower educational attainment and IQ, particularly evident in controls. While negative associations between childhood maltreatment and educational attainment were observed in both affective and nonaffective psychoses, the crude association with IQ was only evident in affective psychoses.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, General & Internal
Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li, Xiong-Jian Luo
Summary: This study identified two new schizophrenia risk loci in the Han Chinese population and 15 novel risk loci through a large-scale meta-analysis in East Asian and European populations. The study also found significant enrichment of schizophrenia heritability in certain genomic regions and tissue types. Additionally, the study highlights the importance of conducting genetic studies in diverse populations for a comprehensive understanding of schizophrenia genetics.
Article
Psychology, Clinical
Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Wanjun Guo, Wei Deng, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li
Summary: This study used TWAS to identify 8 novel risk genes associated with schizophrenia (SCZ). These genes play an important role in frontal-limbic dysfunctions in SCZ patients and could be potential therapeutic targets.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jessica Qian, Corinne Fischer, Amer Burhan, Michael Mak, Philip Gerretsen, Nathan Kolla, Nzaar Al-Chalabi, Zanib Chaudhary, Aisha Qureshey, Ali Bani-Fatemi, Ariel Graff, Gary Remington, Vincenzo De Luca
Summary: This study investigated the epigenetic clocks in schizophrenia patients and their relationship with genes associated with longevity. The findings showed that the telomeric length clock was more indicative of epigenetic age acceleration in schizophrenia patients compared to other biological clocks. These findings suggest the need for further research on the biological mechanisms related to aging and premature mortality in both patients and the general population.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, John Quackenbush, John Platig
Summary: Understanding how individual genotypes influence gene regulation can improve our understanding of human health and development. EGRET is a method that infers genotype-specific gene regulatory networks to reveal the genetic associations driving complex phenotypes.
Article
Psychiatry
Dimitrios Andreou, Kjetil Nordb Jogensen, Laura A. Wortinger, Kristine Engen, Anja Vaskinn, Torill Ueland, Robert H. Yolken, Ole A. Andreassen, Ingrid Agartz
Summary: The study found that CMV infection may affect the intelligence quotient (IQ) of patients with severe mental illness, but not of healthy controls.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
George Anis Sarkis, Nicholas Lees-Gayed, Joseph Banoub, Susan E. Abbatielo, Claudia Robertson, William E. Haskins, Richard A. Yost, Kevin K. W. Wang
Summary: This study explored the concept that TBI may trigger global brain proteolysis in the acute post-injury phase, identifying novel injury-dependent proteolytic peptides in CSF samples. Additionally, endogenous proteolytic peptides discovered in human TBI biofluid could potentially serve as useful diagnostic and monitoring tools for TBI.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Psychology, Clinical
Kazutaka Ohi, Takeshi Otowa, Mihoko Shimada, Tsukasa Sasaki, Hisashi Tanii
PSYCHOLOGICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Kentaro Morita, Kiyotaka Nemoto, Kaori Usui, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Kudo, Hirotsugu Azechi, Yoshiyuki Watanabe, Naoki Hashimoto, Hisashi Narita, Ichiro Kusumi, Kazutaka Ohi, Takamitsu Shimada, Yuzuru Kataoka, Maeri Yamamoto, Norio Ozaki, Go Okada, Yasumasa Okamoto, Kenichiro Harada, Koji Matsuo, Hidenori Yamasue, Osamu Abe, Ryuichiro Hashimoto, Tsutomu Takahashi, Tomoki Hori, Masahito Nakataki, Toshiaki Onitsuka, Laurena Holleran, Neda Jahanshad, Theo G. M. van Erp, Jessica Turner, Gary Donohoe, Paul M. Thompson, Kiyoto Kasai, Ryota Hashimoto
MOLECULAR PSYCHIATRY
(2020)
Article
Clinical Neurology
Kazutaka Ohi, Daisuke Nishizawa, Takamitsu Shimada, Yuzuru Kataoka, Junko Hasegawa, Toshiki Shioiri, Yasuhiro Kawasaki, Ryota Hashimoto, Kazutaka Ikeda
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Shusuke Numata, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Ryuji Furihata, Atsunobu Murata, Takashi Tsuboi, Masahiro Takeshima, Yoshitaka Kyou, Hiroshi Komatsu, Chika Kubota, Shinichiro Ochi, Yoshikazu Takaesu, Masahide Usami, Tatsuya Nagasawa, Akitoyo Hishimoto, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Kazutaka Shimoda, Ryota Hashimoto
Summary: The analysis of discharge prescription data for patients with schizophrenia and MDD revealed differences in prescription patterns for antipsychotics and hypnotics/anxiolytics among patients of different age groups, as well as the common practice of polypharmacy.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki
Summary: This study aimed to compare the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). High-resolution CNV data from 8708 Japanese samples were used to perform the largest cross-disorder analysis of genic and regulatory CNVs in these disorders. The results showed differences in CNV burden, characteristics of CNVs associated with neurodevelopmental disorders, and regulatory CNVs between BD and SCZ/ASD. However, there were also shared molecular mechanisms, particularly in chromatin biology. The study identified specific risk genes for BD that could contribute to understanding the pathogenesis of the disorder.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Hisashi Yamada, Mikuni Motoyama, Naomi Hasegawa, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Norio Yasui-Furukori, Shusuke Numata, Masahiro Takeshima, Nobuhiro Sugiyama, Tatsuya Nagasawa, Chika Kubota, Kiyokazu Atake, Takashi Tsuboi, Kayo Ichihashi, Naoki Hashimoto, Takahiko Inagaki, Yoshikazu Takaesu, Jun-ichi Iga, Hikaru Hori, Toshiaki Onitsuka, Hiroshi Komatsu, Akitoyo Hishimoto, Kentaro Fukumoto, Michiko Fujimoto, Toshinori Nakamura, Kiyotaka Nemoto, Ryuji Furihata, Satoshi Yamamura, Hirotaka Yamagata, Kazuyoshi Ogasawara, Eiichi Katsumoto, Atsunobu Murata, Hitoshi Iida, Shinichiro Ochi, Manabu Makinodan, Mikio Kido, Taishiro Kishimoto, Yuka Yasuda, Masahide Usami, Taro Suwa, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: This study aimed to assess the effectiveness of the EGUIDE project on the clinical behavior of psychiatrists in accordance with clinical practice guidelines. The results showed that the EGUIDE program significantly improved the clinical behaviors of psychiatrists in accordance with guidelines, and these improvements were sustained for at least 2 years.
Article
Psychiatry
Chika Sumiyoshi, Kazutaka Ohi, Haruo Fujino, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Yota Uno, Junichi Takahashi, Kentaro Morita, Asuka Katsuki, Maeri Yamamoto, Yuko Okahisa, Ayumi Sata, Eiichi Katsumoto, Michihiko Koeda, Yoji Hirano, Masahito Nakataki, Junya Matsumoto, Kenichiro Miura, Naoki Hashimoto, Manabu Makinodan, Tsutomu Takahashi, Kiyotaka Nemoto, Toshifumi Kishimoto, Michio Suzuki, Tomiki Sumiyoshi, Ryota Hashimoto
Summary: This study classified individuals with mental disorders based on intellectual abilities and work outcomes, highlighting the effectiveness of transdiagnostic approaches and emphasizing the importance of diagnosis-specific strategies to support functional recovery in people with mental disorders.
Article
Psychology, Clinical
Kazutaka Ohi, Daisuke Nishizawa, Shunsuke Sugiyama, Kentaro Takai, Daisuke Fujikane, Ayumi Kuramitsu, Junko Hasegawa, Midori Soda, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda, Toshiki Shioiri
Summary: Individuals with schizophrenia and bipolar disorder commonly experience cognitive impairments. Genetic risk plays a role in the cognitive impairments of schizophrenia. Cognitive performances differ among individuals with different genetic risks.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Psychiatry
Klaus Oliver Schubert, Anbupalam Thalamuthu, Azmeraw T. Amare, Joseph Frank, Fabian Streit, Mazda Adl, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Bernhard T. Baune
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Hiroyuki Muraoka, Fumitoshi Kodaka, Naomi Hasegawa, Norio Yasui-Furukori, Kentaro Fukumoto, Hiroko Kashiwagi, Hiromi Tagata, Hikaru Hori, Kiyokazu Atake, Hitoshi Iida, Kayo Ichihashi, Ryuji Furihata, Takashi Tsuboi, Masahiro Takeshima, Hiroshi Komatsu, Chika Kubota, Shinichiro Ochi, Yoshikazu Takaesu, Masahide Usami, Tatsuya Nagasawa, Manabu Makinodan, Toshinori Nakamura, Mikio Kido, Ikki Ueda, Hirotaka Yamagata, Toshiaki Onitsuka, Takeshi Asami, Akitoyo Hishimoto, Kazuyoshi Ogasawara, Eiichi Katsumoto, Kenichiro Miura, Junya Matsumoto, Kazutaka Ohi, Hisashi Yamada, Koichiro Watanabe, Ken Inada, Katsuji Nishimura, Ryota Hashimoto
Summary: This study investigated the treatment approaches based on the severity of major depressive disorder (MDD) in real-world clinical practice. The findings revealed a decrease in the use of psychotropics with increasing severity of MDD, while a combination of antipsychotics and antidepressants and the implementation rate of modified electroconvulsive therapy (m-ECT) increased. However, the study also highlighted the existence of an evidence-practice gap in the treatment of MDD in Japan.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Genetics & Heredity
Yuka Yasuda, Junya Matsumoto, Kenichiro Miura, Naomi Hasegawa, Ryota Hashimoto
Summary: Autism spectrum disorders (ASDs) are complex genetic disorders that have been increasing in prevalence. Genetic mutations, interactions between genes and the environment, and epigenetic mechanisms all play important roles in the development and diagnosis of ASD.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Itaru Kushima, Branko Aleksic, Hiroki Kimura, Masahiro Nakatochi, Tzuyao Lo, Masashi Ikeda, Makoto Arai, Ryota Hashimoto, Shusuke Numata, Yasunobu Okamura, Taku Obara, Toshiya Inada, Norio Ozaki
Summary: This study found a significant association between 47, XXY and 47, XXX and the risk of schizophrenia. Patients with schizophrenia and 47, XXY may exhibit treatment resistance and manic symptoms.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Letter
Clinical Neurology
Satsuki Ito, Kenichiro Miura, Mirano Miyayama, Junya Matsumoto, Masaki Fukunaga, Keiichiro Ishimaru, Michiko Fujimoto, Yuka Yasuda, Yoshiyuki Watanabe, Ryota Hashimoto
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Clinical Neurology
Takashi Tsuboi, Yoshikazu Takaesu, Naomi Hasegawa, Shinichiro Ochi, Kentaro Fukumoto, Kazutaka Ohi, Hiroyuki Muraoka, Tsuyoshi Okada, Funitoshi Kodaka, Shun Igarashi, Hitoshi Iida, Hiroko Kashiwagi, Hikaru Hori, Kayo Ichihashi, Kazuyoshi Ogasawara, Naoki Hashimoto, Jun-Ichi Iga, Toshinori Nakamura, Masahide Usami, Tatsuya Nagasawa, Mikio Kido, Hiroshi Komatsu, Hirotaka Yamagata, Kiyokazu Atake, Ryuji Furihata, Saya Kikuchi, Tadasu Horai, Masahiro Takeshima, Yoji Hirano, Manabu Makinodan, Junya Matsumoto, Kenichiro Miura, Akitoyo Hishimoto, Shusuke Numata, Hisashi Yamada, Norio Yasui-Furukori, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The use of electroconvulsive therapy (ECT) may reduce the need for anxiolytic and sleep medication in patients with major depressive disorder (MDD). However, there was no significant difference in anxiolytic and sleep medication use between the ECT and non-ECT groups in patients with schizophrenia (SZ).
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Zlata Polyakova, Masao Iwase, Ryota Hashimoto, Masatoshi Yoshida
Summary: A pharmacological model of schizophrenia symptoms using a subanesthetic dose of ketamine in marmosets was used to study the effects on eye movement characteristics during free-viewing. Ketamine was found to affect saccadic eye movements in marmosets, reducing the amplitude and scanpath length of saccades while increasing the duration of saccades and fixations. These findings suggest that ketamine affects visual exploration but not the oculomotor aspect of saccades in marmosets.
FRONTIERS IN NEUROSCIENCE
(2022)