Article
Immunology
Yixiu Tao, Yingxin Sun, Bo Wu, Donghui Xu, Jun Yang, Liang Gu, Chunling Du
Summary: FOXA2 is underexpressed in CS-exposed mouse lungs, associated with cell senescence and inflammation. Overexpression of FOXA2 delays senescence and inflammation, potentially through regulation of the p38 and Erk1/2 MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rafaela G. A. Costa, Suellen L. R. Silva, Ingrid R. S. B. Dias, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Rosane B. Dias, Daniel P. Bezerra
Summary: Acute myeloid leukemia (AML) is a heterogeneous disease group with various mutations triggering malignant proliferation. AML relapse is mainly caused by leukemic stem cells (LSCs) with self-renewal capacity and resistance to traditional therapies. LSCs have low oxidative stress levels due to low mitochondrial activity and high ROS-removing pathway activity. Targeting oxidative stress could be a potential strategy to eliminate AML LSCs.
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Nanoscience & Nanotechnology
Jun Dou, Luoyang Li, Mei Guo, Feng Mei, Danfeng Zheng, Hui Xu, Rui Xue, Xueyang Bao, Fengshu Zhao, Yu Zhang
Summary: The study found that nanozyme-like Fe3O4 nanoparticles (IONPs) combined with cytosine arabinoside (Ara-C) effectively reduced the AML burden in mice engrafted with leukemia stem cells (LSCs) and extended mouse survival by increasing LSC's reactive oxygen species (ROS) levels to induce LSC apoptosis. The results suggest that targeting LSCs with IONPs plus Ara-C could control AML relapse.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lambros Nousis, Panagiotis Kanavaros, Alexandra Barbouti
Summary: Cellular senescence refers to an irreversible cell cycle arrest, which plays a role in various physiological processes and age-related pathologies. Oxidative stress, caused by an imbalance between the production and elimination of reactive oxygen species (ROS), is a common driver of cellular senescence. Labile iron, necessary for the generation of highly reactive free radicals, has been identified as a potential factor in oxidative stress-induced cellular senescence.
Article
Pharmacology & Pharmacy
Yan Mao, Jinwen Xu, Xuejiao Xu, Jiayun Qiu, Zhengyun Hu, Feng Jiang, Guoping Zhou
Summary: Cellular senescence plays a critical role in carcinogenesis, development, and immunological regulation. This study identified a cellular senescence-related gene signature that can serve as a reliable predictor for clinical outcome and immunotherapeutic response in patients with acute myeloid leukemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuan-Chin Lee, Jing-Ting Chiou, Long-Sen Chang
Summary: The study aimed to investigate the cytotoxic effects of the AMPK inhibitor Compound C in chronic myeloid leukemia (CML) cell lines. Compound C induced apoptosis in certain CML cell lines, and its effects were enhanced by the silencing of SIRT3. Autophagy and downregulation of MCL1 were observed in response to Compound C treatment. The study suggests that AMPK inhibition is a promising strategy for improving CML therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Gui-zhou Zheng, Qi-hao Zhang, Bo Chang, Peng Xie, Hang Liao, Shi-xin Du, Xue-dong Li
Summary: Dioscin exhibits antitumor activities against osteosarcoma cells by inhibiting cell proliferation, migration, and invasion, and inducing apoptosis through upregulation of ROS-mediated p38 MAPK signaling.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sylwester Glowacki, Ewelina Synowiec, Marzena Szwed, Monika Toma, Tomasz Skorski, Tomasz Sliwinski
Summary: Chronic myeloid leukemia (CML) is caused by the BCR-ABL1 protein, inducing oxidative stress and leading to resistance to imatinib (IM). Research shows increased ROS accumulation in BCR-ABL1 positive cells, heightened DNA damage in IM-sensitive cells, and alterations in antioxidant enzyme activity and mitochondrial potential in IM-resistant cells.
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Oncology
Shicong Zhu, Cheng Xing, Guangsen Zhang, Hongling Peng, Zhihua Wang
Summary: Icaritin inhibits cell growth and induces senescence in imatinib-resistant CML cells, possibly through regulation of the JAK2/STAT3/P21 pathway and accumulation of ROS. This suggests icaritin as a promising therapeutic strategy for imatinib-resistant CML patients.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Virology
Sanying Wang, Xuqiang Zhou, Xinyue He, Shushu Ma, Chuan Sun, Jing Zhang, Xiaogang Xu, Weihua Jin, Jin Yan, Ping Lin, Genxiang Mao
Summary: In this study, pterostilbene was found to effectively inhibit the replication of HCMV virus. It acts by suppressing the expression of viral proteins, reducing the replication of viral DNA, and decreasing the viral titer in cells. Furthermore, pterostilbene can also prevent cellular senescence induced by HCMV infection.
Article
Biochemistry & Molecular Biology
Chang Youp Ok, Sera Park, Hye-Ock Jang, Takashi Takata, Ok-Hee Lee, Moon-Kyoung Bae, Soo-Kyung Bae
Summary: The study demonstrated that FK866 could inhibit hydrogen peroxide-induced premature senescence of human dental pulp cells by reducing senescence markers and oxidative stress induction, showing potential therapeutic effects in alleviating inflammation and cellular aging in dental pulp.
Article
Biochemistry & Molecular Biology
Haitao Chen, Ming Tu, Siyi Liu, Yinxian Wen, Liaobin Chen
Summary: In this study, it was found that Dendrobine (DEN) inhibits chondrocyte senescence and osteoarthritis (OA) progression by promoting extracellular matrix synthesis, inhibiting extracellular matrix degradation, reducing expression of inflammatory and senescence factors, improving mitochondrial function, reducing reactive oxygen species production, and suppressing NF-kappa B pathway activation. Furthermore, in vivo experiments demonstrated that DEN alleviated cartilage inflammation, extracellular matrix degradation, and subchondral alterations in OA progression. Therefore, DEN provides an innovative strategy for the treatment of OA through the regulation of the ROS/NF-kappa B axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Shen Wang, Ke Heng, Xingchen Song, Juan Zhai, Huanyu Zhang, Qinghe Geng
Summary: This study suggests that lycopene may have beneficial effects on senile osteoporosis by reducing oxidative stress, cellular senescence, and senescence-associated secretory phenotype (SASP). Lycopene supplementation improves bone mass, microstructure, biomechanical properties, and strength in a senile osteoporosis model. The underlying mechanism may involve the regulation of ROS-accelerated cellular senescence and SASP.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)