Article
Neurosciences
Evgeniy Kreydin, Hui Zhong, Igor Lavrov, V. Reggie Edgerton, Parag Gad
Summary: Spinal cord injury often leads to neurogenic bowel dysfunction, but spinal neuromodulation has been proven to improve sensation and movement in the bowel, and can stimulate the anorectal regions for beneficial effects on patients' bowel program.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Adam W. Doelman, Femke Streijger, Steve J. A. Majerus, Margot S. Damaser, Brian K. Kwon
Summary: Neurogenic bladder dysfunction is a common condition after spinal cord injury, and animal models are crucial for studying its mechanisms and testing potential therapies. This review summarizes the use of animal models, particularly cystometry testing, in assessing SCI-related NLUTD. The advantages, disadvantages, and future research opportunities of different animal models are also discussed.
Article
Health Care Sciences & Services
Nathalie Elisabeth Perez, Neha Pradyumna Godbole, Katherine Amin, Raveen Syan, David R. Gater
Summary: This article discusses the common causes and physiological abnormalities that can lead to urinary incontinence after spinal cord injury. It also explores the pathophysiology associated with spinal cord injury, including the diagnosis and treatment of autonomic dysreflexia and the risks to the kidneys and ureters. The article also reviews recent guidelines on the diagnosis, evaluation, treatment, and follow-up of neurogenic bladder, as well as the available management options.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Hueih Ling Ong, I-Ni Chiang, Lin-Nei Hsu, Cheih-Wen Chin, I-Hung Shao, Mei-Yu Jang, Yung-Shun Juan, Chung-Cheng Wang, Hann-Chorng Kuo
Summary: This article reviews the available data on non-surgical management for neurogenic lower urinary tract dysfunction (NLUTD) in patients with chronic spinal cord injury (SCI) and provides the most updated knowledge for readers. The bladder management approaches for storage and voiding dysfunction are minimally invasive, safe, and efficacious procedures. The main goals for NLUTD management are urinary continence, improved quality of life, prevention of urinary tract infections, and preservation of upper urinary tract function. However, there is a lack of high-quality evidence and new minimally invasive treatments for NLUTD, requiring collaboration between urologists, nephrologists, and physiatrists to ensure the health of SCI patients in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yu Hui Won, Da-Sol Kim, Gi-Wook Kim, Sung-Hee Park, Myoung-Hwan Ko, Jeong-Hwan Seo
Summary: Trabeculation grade can be used to classify suprasacral neurogenic bladder. Parameters such as disease duration, bladder capacity, and detrusor pressure show significant differences among different grades of trabeculation. Vesicoureteral reflux has a moderate correlation with trabeculation grade.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Clinical Neurology
Sally El Sammak, Giorgos D. Michalopoulos, Namrata Arya, Archis R. Bhandarkar, F. M. Moinuddin, Ryan Jarrah, Yagiz U. Yolcu, Ali Shoushtari, Mohamad Bydon
Summary: Neurogenic bladder is a common complication after spinal cord injury (SCI) that carries substantial burdens on the inflicted individual. This study aimed to build a prediction model for neurogenic bladder recovery 1 year after traumatic SCI.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Lin Chen, Yunbo Li
Summary: This study investigated the efficacy of using magnetic stimulation of sacral nerve roots combined with Tui-na for treating neurogenic bladder after spinal cord injury (SCI). The results showed that this combination treatment was effective in improving bladder function and quality of life, and was superior to using magnetic stimulation or Tui-na alone.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Ralf Boethig, Christian Tiburtius, Wolfgang Schoeps, Michael Zellner, Oliver Balzer, Birgitt Kowald, Sven Hirschfeld, Roland Thietje, Aki Pietsch, Ines Kurze, Martin Forchert, Thura Kadhum, Klaus Golka
Summary: The study found that bladder cancer in SCI patients differs significantly from that in able-bodied patients, with bladder cancer in SCI patients occurring at a younger age, having a shorter survival time, and often presenting with more aggressive types. Bladder cancer is typically diagnosed in SCI patients after 10 years or more of injury. A decision-making aid based on the findings can be a useful tool in clinical practice for assessing the correlation between SCI and bladder cancer.
MILITARY MEDICAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Joslyn Gober, Sruthi P. Thomas, David R. Gater
Summary: This manuscript discusses the epidemiology, pathophysiology, prevention, and management strategies for pediatric spina bifida and spinal cord injury. Growing and developing children are at high risk for spinal cord tethering, syringomyelia, and other complications that must be addressed carefully. Proper management of neurogenic bladder and neurogenic bowel is crucial for both medical safety and psychosocial integration into the child's expanding social circle.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Diana M. M. Molinares, David R. R. Gater, Scott Daniel, Nicole L. L. Pontee
Summary: This article discusses the essential role of the spinal cord in the central nervous system and the various complications that arise after traumatic and nontraumatic spinal cord injuries. It also outlines the pathophysiology and classification of nontraumatic spinal cord injuries, and provides management strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
Andrea M. Sartori, Anna-Sophie Hofer, Myriam Scheuber, Ruslan Rust, Thomas M. Kessler, Martin E. Schwab
Summary: Neurogenic lower urinary tract dysfunction commonly occurs after spinal cord injury, characterized by detrusor overactivity and detrusor-sphincter-dyssynergia. Changes in spinal cord anatomy, including increased C-fiber afferents and decreased CRF-positive and 5-HT-positive neuronal projections, contribute to the development of lower urinary tract symptoms.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Engineering, Biomedical
Fei Hao, Fan Jia, Peng Hao, Hongmei Duan, Zijue Wang, Yubo Fan, Wen Zhao, Yudan Gao, Orion R. Fan, Fuqiang Xu, Zhaoyang Yang, Yi E. Sun, Xiaoguang Li
Summary: Activation of endogenous neurogenesis using bioactive materials can restore sensory/motor function in complete spinal cord injury patients through the formation of new neural circuits. The wiring logic of newborn neurons in the adult central nervous system remains unknown. This study demonstrated that neurotrophin3-loaded chitosan biomaterial effectively restored bladder function after spinal cord injury. The use of neuro-circuitry tracing technologies revealed that newborn neurons were integrated into micturition neural circuits and reconnected brain and spinal cord centers for voiding control, facilitating the restoration of lower urinary tract function.
Review
Medicine, General & Internal
Y. T. Zang, M. J. Bai, L. Wang, M. X. Zhang, L. Li
Summary: This study aimed to systematically review and quantify the association between acupuncture and pelvic floor muscle exercise and bladder dysfunction rehabilitation in individuals with spinal nerve injury. Through literature search and meta-analysis, the results showed that acupuncture and pelvic floor muscle exercise have significant effects on the treatment of bladder dysfunction after spinal nerve injury.
Article
Urology & Nephrology
Pawan Vasudeva, Vishnu Prasad, Siddharth Yadav, Niraj Kumar, Kumar Saurav, Y. M. Prashanth, Vijay Tyagi
Summary: Mirabegron demonstrates clinical efficacy and safety in patients with neurogenic detrusor overactivity (NDO) due to traumatic spinal cord injury. Treatment with Mirabegron led to improvements in frequency of clean intermittent catheterization (CIC), CIC volume, incontinence episodes, and cystometric capacity, with only minor side effects reported.
NEUROUROLOGY AND URODYNAMICS
(2021)
Review
Medicine, General & Internal
Lei Xiang, Han Li, Qi-Qi Xie, Ching Sin Siau, Zhi Xie, Meng-Ting Zhu, Bo Zhou, Zhi-Peng Li, Shuai-Bin Wang
Summary: This article summarizes the research progress on rehabilitation treatment and nursing care for patients with neurogenic bladder after spinal cord injury, aiming to provide reference for their rehabilitation treatment and nursing care. Recent medical literature on patients with neurogenic bladder, specifically caused by spinal cord injury, was reviewed. Additionally, 30 publications were analyzed to evaluate commonly used rehabilitation nursing methods for neurogenic bladder. Psychological counseling plays a crucial role in neurogenic bladder rehabilitation. Intermittent catheterization in patients with neurogenic bladder after spinal cord injury may improve their quality of life, alleviate psychological burden, and reduce negative emotions.
WORLD JOURNAL OF CLINICAL CASES
(2023)