Article
Food Science & Technology
Juanjuan Cheng, Xingdong Ma, Guangtao Yan, Qiuxia Yu, Zhen Huang, Guoshu Lin, Mengyao Li, Fengkun Guan, Ziren Su, Fang Yan, Yuhong Liu, Qingfeng Xie
Summary: This study aimed to examine the protective effect of berberine against fructose-induced insulin resistance in rats and L6 cells and its potential activation mechanism on AMPK. The results showed that berberine effectively reversed body weight gain, dyslipidemia, and insulin intolerance. Moreover, berberine alleviated inflammation, enhanced antioxidant capacity, and promoted glucose uptake. The beneficial effect was associated with the upregulation of Nrf2 and AKT/GLUT4 pathways, regulated by AMPK, and berberine activated AMPK by increasing AMP levels and the AMP/ATP ratio while suppressing AMPD1 and promoting ADSL expression.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Nutrition & Dietetics
Aline Fernandes-da-Silva, Carolline Santos Miranda, Daiana Araujo Santana-Oliveira, Brenda Oliveira-Cordeiro, Camilla Rangel-Azevedo, Flavia Maria Silva-Veiga, Fabiane Ferreira Martins, Vanessa Souza-Mello
Summary: Obesity challenges lipid and carbohydrate metabolism, leading to glucolipotoxicity and ER dysfunction, triggering ER stress and metabolic abnormalities. Dietary interventions can alleviate ER stress induced by excessive fat or sugar intake, impacting adipose tissue, liver, and pancreas function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Nuria Roglans, Elena Fauste, Roger Bentanachs, Ana M. Velazquez, Madelin Perez-Armas, Cristina Donis, Maria Panadero, Marta Alegret, Paola Otero, Carlos Bocos, Juan C. Laguna
Summary: In our study, we found that the HFHFr diet reduces the production of liver H2S, mainly by decreasing the expression of CBS and CSE. However, treatment with BemA restores H2S production by increasing the expression of CBS and CSE, suggesting the involvement of the FXR transcriptional activity and the mTORC1/S6K1/PGC1 alpha pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ravinder Naik Dharavath, Shiyana Arora, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Kanwaljit Chopra
Summary: SGZ treatment significantly reversed metabolic and cognitive alterations induced by a high fat-low protein diet, improving peripheral glucose and lipid profiles, as well as enhancing cerebral glucose homeostasis, BBB integrity, and reducing oxidative stress and neuroinflammation.
Article
Biochemistry & Molecular Biology
Thiago da Rosa Lima, Fabricio Azevedo Voltarelli, Lorena Silva Freire, Franciely Alves da Silva, Paula Caroline de Almeida, Eudes Thiago Pereira Avila, Suelem Aparecida de Franca, Mayara Peron Pereira, Amilcar Sabino Damazo, James Wilfred Navalta, Carlos Alexandre Fett, Nair Honda Kawashita
Summary: This study found that combining a high-fat diet with a fructose drink resulted in metabolic and hormonal changes more similar to human obesity. The high-fat diet group showed higher body weight and other related indicators compared to the control group.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Aline F. P. Souza, Juliana Woyames, Rosiane A. Miranda, Lorraine S. Oliveira, Bruna Caetano, Isabela L. Martins, Manuella S. Souza, Cherley B. Andrade, Thais Bento-Bernardes, Flavia F. Bloise, Rodrigo S. Fortunato, Isis H. Trevenzoli, Luana L. Souza, Carmen C. Pazos-Moura
Summary: This study investigates the effects of maternal high-fat diet on the liver mitochondrial responses to fructose intake in adult offspring. It found that moderate maternal high-fat diet can increase the intensity of liver mitochondrial alterations induced by fructose in offspring. The findings suggest that maternal diet can influence the risk of fructose damage in the liver of adult offspring.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, General & Internal
Francesca De Vito, Evelina Suraci, Raffaella Marasco, Francesco Luzza, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino
Summary: Increased levels of duodenal GLUT-5 are associated with NAFLD and liver fibrosis. Inhibition of intestinal GLUT-5-mediated fructose uptake may be a strategy for preventing and treating NAFLD.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Arturo Jimenez-Chavez, Russell Morales-Rubio, Eliu Sanchez-Gasca, Monica Rivera-Rosas, Marisela Uribe-Ramirez, Omar Amador-Munoz, Y. Margarita Martinez-Dominguez, Irma Rosas-Perez, Elizabeth H. Choy, David A. Herman, Michael T. Kleinman, Andrea De Vizcaya-Ruiz
Summary: Insulin resistance and metabolic disorders can be induced by exposure to fine particulate matter (PM2.5) and high fructose sweeteners and fat rich diets. In this study, concomitant exposure to PM2.5 and a fructose rich diet led to leptin release, systemic hyperinsulinemia, Insulin/AKT dysregulation, histological damage, and increased HOMA-IR. These findings suggest that the combination of ubiquitous environmental pollutant PM2.5 and metabolic disease risk factor FRD can contribute to the global pandemic of metabolic disorders.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Michelle Moughaizel, Elie Dagher, Nora Bouhsina, Valerie Lalanne, Chantal Thorin, Jean-Claude Desfontis, M. Yassine Mallem
Summary: The study investigates the therapeutic potential of mirabegron for the treatment of metabolic syndrome. The long-term treatment with mirabegron in WHHL rabbits prevented the increase in TG levels and the establishment of insulin resistance, while enhancing cardiac function. However, it also aggravated atherosclerosis development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Marieh Salavatizadeh, Samira Soltanieh, Amirhossein Ataei Kachouei, Zahra Abdollahi Fallahi, Hamed Kord-Varkaneh, Hossein Poustchi, Asieh Mansour, Mohammad E. Khamseh, Fariba Alaei-Shahmiri, Heitor O. Santos, Azita Hekmatdoost
Summary: Dietary glycemic index (GI) is associated with the odds of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Higher GI diets are associated with increased risk of NAFLD in individuals with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Erin J. Stephenson, Amanda S. Stayton, Aarti Sethuraman, Prahlad K. Rao, Charles Klazer Gomes, Molly C. Mulcahy, Liam McAllan, Michelle A. Puchowicz, Joseph F. Pierre, Dave Bridges, Joan C. Han
Summary: This study found that sucrose intake induces sexually dimorphic effects and influences the severity of fatty liver disease and the contribution of fatty acid synthesis to hepatic triglycerides in a sex-dependent manner. These findings demonstrate the role of sex in sucrose-induced fatty liver and highlight the importance of extrahepatic metabolism in the pathogenesis of diet-induced fatty liver and NAFLD.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Jun Wang, Wentong Zhang, Mingkai Li, Xia Li
Summary: Bis 3, a coumarin derivative, shows significant protective effects against HFD-induced obesity in mice, by reducing body weight gain, inhibiting insulin resistance, maintaining intestinal integrity, preventing lipid metabolic disorders, and improving cognitive impairments as a potent free radical scavenger.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Arash Karimi, Mahdi Vajdi, Sarvin Sanaie, Shiva Akhlaghi, Aida Negari, Farzaneh Dashti, Pouria Sefidmooye Azar
Summary: This systematic review evaluated the effects and mechanisms of berberine (BBR) in the management of nonalcoholic fatty liver disease (NAFLD) and its complications. The results revealed that BBR can regulate NAFLD development through mechanisms such as weight reduction, modulation of lipid and glucose metabolism, and reduction of inflammation and oxidative stress. BBR has potential therapeutic effects in managing NAFLD and its associated risk factors.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Qing-Song Xia, Fan Wu, Wen-Bin Wu, Hui Dong, Zhao-Yi Huang, Lijun Xu, Fu-Er Lu, Jing Gong
Summary: This study explores the relationship between hepatic hypoxia, ceramide synthesis, and insulin resistance, and demonstrates that berberine can reduce ceramide production and attenuate insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Piyachat Chansela, Bubphachat Potip, Jittima Weerachayaphorn, Niwat Kangwanrangsan, Natsasi Chukijrungroat, Vitoon Saengsirisuwan
Summary: This study found that a combination of excessive caloric intake and estrogen deficiency leads to morphological changes in pancreatic islets, worsening insulin resistance and the development of diabetes. However, these changes can be reversed by estrogen replacement therapy.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)