期刊
JOURNAL OF HOSPITAL INFECTION
卷 101, 期 1, 页码 42-46出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2018.09.005
关键词
Post-exposure prophylaxis; Middle East respiratory syndrome coronavirus; Outbreak; Healthcare worker; High-risk exposure; Pre-isolation pneumonia
资金
- Hallym University Research Fund [HURF-2014-58]
An effective post-exposure prophylaxis (PEP) strategy may limit the spread of infection. However, there is no consensus regarding PEP for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. This study assessed the efficacy of ribavirin and lopinavir/ritonavir as PEP for healthcare workers (HCWs) exposed to patients with severe MERS-CoV pre-isolation pneumonia. The safety of the PEP regimen was assessed. HCWs with high-risk exposure to MERS-CoV pre-isolation pneumonia were retrospectively enrolled. HCWs who received PEP therapy were classified into the PEP group. PEP therapy was associated with a 40% decrease in the risk of infection. There were no severe adverse events during PEP therapy. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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