期刊
JOURNAL OF HOSPITAL INFECTION
卷 82, 期 2, 页码 114-121出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2012.06.014
关键词
Chlorine-releasing agent; Clostridium difficile; Cost effectiveness; Disinfection; Environmental surfaces
资金
- Derby Hospitals NHS Foundation Trust Research and Development Office [DHRD/2009/077]
- Facilities Management Department
Background: Clostridium difficile spores can survive in the environment for months or years, and contaminated environmental surfaces are important sources of nosocomial C. difficile transmission. Aim: To compare the clinical and cost effectiveness of eight C. difficile environmental disinfection methods for the terminal cleaning of hospital rooms contaminated with C. difficile spores. Methods: This was a novel randomized prospective study undertaken in three phases. Each empty hospital room was disinfected, then contaminated with C. difficile spores and disinfected with one of eight disinfection products: hydrogen peroxide vapour (HPV; Bioquell Q10) 350-700 parts per million (ppm); dry ozone at 25 ppm (Meditrox); 1000 ppm chlorine-releasing agent (Actichlor Plus); microfibre cloths (Vermop) used in combination with and without a chlorine-releasing agent; high temperature over heated dry atomized steam cleaning (Polti steam) in combination with a sanitizing solution (HPMed); steam cleaning (Osprey steam); and peracetic acid wipes (Clinell). Swabs were inoculated on to C. difficile-selective agar and colony counts were performed pre and post disinfection for each method. A cost-effectiveness analysis was also undertaken comparing all methods to the current method of 1000 ppm chlorine-releasing agent (Actichlor Plus). Findings: Products were ranked according to the log(10) reduction in colony count from contamination phase to disinfection. The three statistically significant most effective products were hydrogen peroxide (2.303); 1000 ppm chlorine-releasing agent (2.223) and peracetic acid wipes (2.134). Conclusion: The cheaper traditional method of using a chlorine-releasing agent for disinfection was as effective as modern methods. (c) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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