Article
Biophysics
William Teixeira, Yeray Pallas-Tamarit, Augusto Juste-Dolz, Amadeo Sena-Torralba, Roberto Gozalbo-Rovira, Jesus Rodriguez-Diaz, David Navarro, Javier Carrascosa, David Gimenez-Romero, Angel Maquieira, Sergi Morais
Summary: The COVID-19 pandemic has increased the demand for rapid and reliable point-of-care testing devices. This study presents an all-in-one POCT device that can perform parallel viral antigen and serological analysis. The biosensor demonstrates high diagnostic sensitivity and specificity for various respiratory viruses.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Multidisciplinary
Zhaowei Zhang, Peng Ma, Rajib Ahmed, Jie Wang, Demir Akin, Fernando Soto, Bi-Feng Liu, Peiwu Li, Utkan Demirci
Summary: The passage highlights the global threats caused by human acute respiratory virus infections and the importance of new technologies in addressing the inadequacies of traditional detection methods. It emphasizes the key elements in clinical sample testing and the significance of sensitivity, specificity, and speed in detecting respiratory viruses.
ADVANCED MATERIALS
(2022)
Article
Immunology
Roy P. Zuurbier, Koos Korsten, Theo J. M. Verheij, Chris Butler, Niels Adriaenssens, Samuel Coenen, Olivier Gruselle, Valerie Vantomme, Marlies A. van Houten, Louis J. Bont, Joanne G. Wildenbeest
Summary: The study compared the performance of Xpert (R) Xpress Flu/RSV assay with real-time RT-PCR in detecting respiratory syncytial virus (RSV) infection in home-dwelling older adults. The Xpert (R) Xpress Flu/RSV assay showed high positive percentage agreement (PPA) for RSV detection in older adults, with fast and easy point-of-care use.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Article
Virology
Jessica Santiago Cruz, Luciano Kleber de Souza Luna, Vitoria Rodrigues Guimaraes Alves, Danielle Dias Conte, Nancy Cristina Junqueira Bellei
Summary: RSV plays a significant role in acute respiratory infections among children. Viral load may impact disease severity and clinical presentation. Age and coinfection with other pathogens can also influence RSV infection outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Critical Care Medicine
Tristan W. Clark, Kate R. Beard, Nathan J. Brendish, Ahalya K. Malachira, Samuel Mills, Cathleen Chan, Stephen Poole, Sean Ewings, Nick Cortes, Esther Nyimbili, Laura Presland
Summary: The study aimed to evaluate the impact of mPOCT on influenza detection and clinical outcomes in hospitalized patients. The results showed that the mPOCT group had a higher rate of influenza detection, more timely and appropriate antiviral treatment, and isolation facility use, which contributed to improved clinical outcomes.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Melissa R. Riester, Elliott Bosco, Rishik Manthana, Melissa Eliot, Barbara H. Bardenheier, Joe B. B. Silva, Robertus van Aalst, Ayman Chit, Matthew M. Loiacono, Stefan Gravenstein, Andrew R. Zullo
Summary: This study aimed to quantify the relationship between increasing influenza and RSV community viral activity and cardiorespiratory rehospitalizations among older adults discharged to skilled nursing facilities (SNFs). The results showed that cardiorespiratory rehospitalization rates increased by approximately 1% for every 5% increase in circulating influenza A(H3N2), influenza B, and RSV, but decreased by 1% for every 5% increase in circulating influenza A(H1N1pdm09). During the respiratory virus season, cardiorespiratory rehospitalization rates increased by approximately 6% for influenza A(H3N2), 3% for influenza B, and 5% for RSV, but decreased by 6% for influenza A(H1N1pdm09).
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Medicine, General & Internal
Laura L. Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir A. Madhi, William J. Muller, Heather J. Zar, Dennis Brooks, Amy Grenham, Ulrika Wahlby Hamren, Vaishali S. Mankad, Pin Ren, Therese Takas, Michael E. Abram, Amanda Leach, M. Pamela Griffin, Tonya Villafana
Summary: A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Understanding the interaction between RSV and the host is crucial for developing effective interventions. This study identifies the RSV nonstructural protein NS2 as the key component in activating autophagy by modulating the ISGylation of Beclin1.
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Paramyxoviruses like RSV are a leading cause of viral pneumonia in infants. This study identified the viral protein NS2 as mediating autophagy induction by RSV, providing a potential target for interventions against RSV.
Review
Immunology
Chukwuemeka Onwuchekwa, Jessica Atwell, Laura Mora Moreo, Sonia Menon, Belen Machado, Mariana Siapka, Neha Agarwal, Michelle Rubbrecht, Zuleika Aponte-Torres, Mark Rozenbaum, Daniel Curcio, Harish Nair, Warren Kalina, Hilde Vroling, Bradford Gessner, Elizabeth Begier
Summary: This study investigated whether adding additional specimen types to nasopharyngeal swab RT-PCR increased RSV detection in children. The results showed that adding multiple specimens did not substantially increase RSV detection, but even small proportional increases could result in meaningful changes in burden estimates.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Li Wang, Qihui Zhu, Kunlun Xiang, Yaling Zhang, Baocun Li, Xin Yu, Guang Yang, Chungen Liang, Hongying Yun, Meifang Zhang, Ning Qin, Lu Gao
Summary: A novel triazole-oxadiazole derivative named triazole-1 was discovered as an inhibitor of respiratory syncytial virus (RSV) replication. Triazole-1 showed potent inhibition of both RSV A and B subtypes and specifically targeted RSV transcription, with resistance observed due to a single point mutation in the RSV genome.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Mina Suh, Naimisha Movva, Xiaohui Jiang, Lauren C. Bylsma, Heidi Reichert, Jon P. Fryzek, Christopher B. Nelson
Summary: This study demonstrates that acute bronchiolitis due to RSV is the leading cause of hospitalizations in US infants, especially during the winter months.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Ruth Forrest, Laura Jones, Lorna Willocks, Alison Hardie, Kate Templeton
ARCHIVES OF DISEASE IN CHILDHOOD
(2017)
Article
Infectious Diseases
A. Tostevin, E. White, D. Dunn, S. Croxford, V. Delpech, I. Williams, D. Asboe, A. Pozniak, D. Churchill, A. M. Geretti, D. Pillay, C. Sabin, A. Leigh-Brown, E. Smit
Article
Public, Environmental & Occupational Health
J. Danial, S. Ballard-Smith, C. Horsburgh, C. Crombie, A. Ovens, K. E. Templeton, A. Hardie, F. Cameron, L. Harvey, J. Stevenson, I. Johannessen
JOURNAL OF HOSPITAL INFECTION
(2016)
Article
Infectious Diseases
Naomi J. Gadsby, Kristjan O. Helgason, Elizabeth M. Dickson, Jonathan M. Mills, Diane S. J. Lindsay, Giles F. Edwards, Mary F. Hanson, Kate E. Templeton
JOURNAL OF INFECTION
(2016)
Letter
Respiratory System
Andrew Conway Morris, Naomi Gadsby, James P. McKenna, Thomas P. Hellyer, Paul Dark, Suveer Singh, Timothy S. Walsh, Danny F. McAuley, Kate Templeton, A. John Simpson, Ronan McMullan
Article
Public, Environmental & Occupational Health
L. J. Willocks, D. Guerendiain, H. I. Austin, K. E. Morrison, R. L. Cameron, K. E. Templeton, V. R. F. De Lima, R. Ewing, W. Donovan, K. G. J. Pollock
EPIDEMIOLOGY AND INFECTION
(2017)
Article
Microbiology
M. P. McHugh, A. H. B. Wu, S. Chevaliez, J. M. Pawlotsky, M. Hallin, K. E. Templeton
JOURNAL OF CLINICAL MICROBIOLOGY
(2017)
Article
Microbiology
R. H. T. Nijhuis, D. Guerendiain, E. C. J. Claas, K. E. Templeton
JOURNAL OF CLINICAL MICROBIOLOGY
(2017)
Article
Microbiology
Johannes Brennecke, Simone Kraut, Klara Zwadlo, Senthil Kumar Gandi, David Pritchard, Kate Templeton, Till Bachmann
JOURNAL OF MEDICAL MICROBIOLOGY
(2017)
Article
Virology
Martin P. McHugh, Daniel Guerendiain, Alison Hardie, Juliet Kenicer, Laura MacKenzie, Kate E. Templeton
JOURNAL OF CLINICAL VIROLOGY
(2018)
Article
Gastroenterology & Hepatology
A. L. McNaughton, V. B. Sreenu, G. Wilkie, R. Gunson, K. Templeton, E. C. M. Leitch
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Infectious Diseases
Helen Fifer, Michelle Cole, Gwenda Hughes, Simon Padfield, Christa Smoarchuk, Ned Woodford, Adrian Wensley, Nazim Mustafa, Ulf Schaefer, Richard Myers, Kate Templeton, Jill Shepherd, Apthony Underwood
LANCET INFECTIOUS DISEASES
(2018)
Article
Cell & Tissue Engineering
S. T. J. Tsang, M. P. McHugh, D. Guerendiain, P. J. Gwynne, J. Boyd, A. H. R. W. Simpson, T. S. Walsh, I. F. Laurenson, K. E. Templeton
BONE & JOINT RESEARCH
(2018)
Article
Microbiology
Martin P. McHugh, Benjamin J. Parcell, Fiona M. MacKenzie, Kate E. Templeton
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Infectious Diseases
Michelle J. Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J. Amato-Gauci, Magnus Unemo
BMC INFECTIOUS DISEASES
(2017)