Article
Multidisciplinary Sciences
Raveen Rathnasinghe, Sonia Jangra, Lisa Miorin, Michael Schotsasert, Clifford Yahnke, Adolfo Garcia-Sastre
Summary: Research shows that visible light (405 nm) has potential in germicidal applications, utilizing reactive oxygen species to deactivate pathogens, especially effective against respiratory pathogens such as SARS-CoV-2 and influenza virus. This method, which is porphyrin-independent, is safe and commercially viable.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Hanyu Chen, Carmen Moraru
Summary: This study explores the potential of using sequential treatments with different wavelengths to enhance the disinfection performance of individual treatments against foodborne pathogens. The results show that pre-treatments with 280 and 222 nm can increase the effectiveness of follow-up 405 nm treatments by inducing higher levels of cellular membrane damage and oxidative stress. These findings provide useful information for light equipment manufacturers, food processors, and healthcare users, and have the potential to improve germicidal light technologies and enhance food safety and public health.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Microbiology
Teresa Fasciana, Maria Letizia Gargano, Nicola Serra, Elena Galia, Ignazio Arrigo, Maria Rita Tricoli, Orazia Diquattro, Giuseppa Graceffa, Salvatore Vieni, Giuseppe Venturella, Anna Giammanco
Summary: The study found that extracts from albino Grifola frondosa could effectively inhibit the growth of certain bacteria and biofilm production by Staphylococcus aureus, reducing the presence of biofilm. This indicates that albino Grifola frondosa extracts could be utilized as functional food and natural additives for food processing control and safety.
Article
Public, Environmental & Occupational Health
S. -C. Wong, J. H. -K. Chen, S. Y. -C. So, P. -L. Ho, K. -Y. Yuen, V. C. -C. Cheng
Summary: Gastrointestinal colonization of MRSA may contribute to adverse clinical outcomes and pose an unrecognized burden upon hospital infection control.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Microbiology
Viswanath Ragupathy, Mohan Haleyurgirisetty, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Indira Hewlett, Chintamani Atreya
Summary: Despite advances in ensuring blood supply safety, there is still a risk of transfusion transmitted infections (TTIs) from emerging infections. New pathogen reduction technologies (PRTs) using violet-blue light at 405 nm have shown promise in effectively inactivating pathogens in blood, including bacteria, parasites, and viruses.
Article
Public, Environmental & Occupational Health
S. Miyakis, S. Brentnall, M. Masso, G. Reynolds, M. K. Byrne, P. Newton, S. Crawford, J. Fish, B. Nicholas, T. Hill, A. M. van Oijen
Summary: The study compared patients with MRSA infection and MSSA infection, finding that MRSA infection was associated with significantly increased inpatient mortality, costs, and hospital length of stay. Key predictors of MRSA infection included date of index admission, comorbidity score, socio-economic disadvantage, and age.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Public, Environmental & Occupational Health
L. Renggli, M. Gasser, C. Pluss-Suard, A. Kronenberg
Summary: Consumption of anti-MRSA antibiotics in Switzerland increased significantly between 2009 and 2019. Factors such as number of MRSA cases, year, hospital type, hospital department, and linguistic region were found to affect consumption. Additionally, the presence of an antibiotic stewardship group and prescription restrictions were associated with lower consumption of anti-MRSA antibiotics.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Public, Environmental & Occupational Health
R. Cohen, M. Afraimov, T. Finn, F. Babushkin, K. Geller, H. Alexander, S. Paikin
Summary: The study identified multiple temporally distinct clonal outbreaks of MRSA in a ward of a long-term care facility, causing recurrent bloodstream infections, with healthcare workers playing a significant role in transmission.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Materials Science, Multidisciplinary
Louise Breloy, Vlasta Brezova, Zuzana Barbierikova, Yoshihiro Ito, Jun Akimoto, Annalisa Chiappone, Samir Abbad-Andaloussi, Jean-Pierre Malval, Davy-Louis Versace
Summary: This study reported the high initiating properties of quinizarin derivatives under visible-light irradiation, achieving high conversions when combined with various co-initiators. The use of soybean oil acrylate led to highly cross-linked materials with comparable mechanical properties under visible-light. Moreover, the copolymerization of the photosensitizer with the polymer matrix not only prevented leakage, but also ensured antiadhesion properties against Staphylococcus aureus under visible-light activation.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Optics
Zhong Wang, Muling Chen, Weihua Zhang
Summary: We investigated the super-resolution light modulation capability of Si nanodisks in the visible spectral range. By developing an optimization algorithm based on Laguerre-Gaussian beams, focused spots below 45 nm were achieved with 405 nm light. The ability to synthesize complex nano-patterns by superposing multiple focus spots together suggests that Si nanodisks hold promise as a tool for super-resolution photolithography.
Review
Medicine, General & Internal
David K. H. Lo, Marianne S. Muhlebach, Alan R. Smyth
Summary: Cystic fibrosis patients are often affected by pulmonary infections caused by MRSA, leading to lung function decline and early mortality. Clear guidance for MRSA eradication is urgently needed, but lacks robust evidence support.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Infectious Diseases
Artur J. Sabat, Erik Bathoorn, Monika A. Chlebowicz-Fliss, Viktoria Akkerboom, Inge Kamphuis, Claudy Oliveira Dos Santos, Alexander W. Friedrich
Summary: This study describes two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay, indicating that this MRSA strain may have been spreading in the northern Netherlands for some time and could have disseminated to other regions.
Article
Pharmacology & Pharmacy
Masakazu Kitahara, Shin Takayama, Tetsuya Akaishi, Akiko Kikuchi, Tadashi Ishii
Summary: This study demonstrated that administration of HET in acute stroke patients can effectively prevent MRSA colonization and reduce the incidence of infectious diseases, leading to improved rehabilitation outcomes within three months.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Katlyn M. Lake, Shelley C. Rankin, Wayne S. Rosenkrantz, Lakshmi Sastry, Megan Jacob, Dubra Diaz Campos, Kelli Maddock, Stephen D. Cole
Summary: The study shows that 0.2% and 0.4% sodium oxychlorosene solutions have a bactericidal effect against MRSP in vitro. Further research is needed to determine whether it is an appropriate alternative therapy for canine pyoderma.
VETERINARY DERMATOLOGY
(2023)
Article
Microbiology
Diana Gutierrez, Lorena Rodriguez-Rubio, Patricia Ruas-Madiedo, Lucia Fernandez, Ana Belen Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar Garcia, Ana Rodriguez
Summary: A series of engineered proteins based on endolysins were designed and screened, with LysRODI Delta Ami identified as having high lytic activity, stability, and antimicrobial properties to effectively prevent and treat Staphylococcus aureus skin infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caitlin F. Stewart, Rachael M. Tomb, Heather J. Ralston, Jack Armstrong, John G. Anderson, Scott J. MacGregor, Chintamani D. Atreya, Michelle Maclean
Summary: This study demonstrates that the use of 405-nm light can effectively and safely inactivate bacteria in ex vivo stored blood plasma, while preserving protein integrity. These findings highlight the potential of 405-nm light for improving blood safety and reducing transfusion-transmitted infections.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ana Rita Rebelo, Tobias Ibfelt, Valeria Bortolaia, Pimlapas Leekitcharoenphon, Dennis Schroder Hansen, Hans Linde Nielsen, Svend Ellermann-Eriksen, Michael Kemp, Bent Lowe Roder, Niels Frimodt-Moller, Turid Snekloth Sondergaard, John Eugenio Coia, Claus Ostergaard, Michael Pedersen, Henrik Westh, Frank Moller Aarestrup
Summary: This study examined the feasibility of implementing whole-genome sequencing technologies in clinical microbiology laboratories and analysed the distribution of bacterial species processed in clinical settings in Denmark. The results showed that E. coli and Staphylococcus were the most prevalent bacteria, with uneven distribution across the country.
Article
Medicine, General & Internal
Kim Oren Gradel, Thomas Stauffer Larsen, Henrik Frederiksen, Pernille Just Vinholt, Maria Iachina, Pedro Povoa, Fernando Godinho Zampieri, Stig Lonberg Nielsen, Ram Benny Dessau, Jens Kjolseth Moller, Thoger Gorm Jensen, Ming Chen, John Eugenio Coia, Jelena Jelicic
Summary: In this study, the impact of C-reactive protein and plasma albumin levels on the survival rate of patients with diffuse large B-cell lymphoma was investigated by amending the International Prognostic Index. The results showed that plasma albumin level played a crucial role in short-term prognosis and discriminatory ability, especially when the level was lower.
ANNALS OF MEDICINE
(2022)
Article
Immunology
Ulrik S. Justesen, Stig L. Nielsen, Thoger G. Jensen, Ram B. Dessau, Jens K. Moller, John E. Coia, Steen L. Andersen, Court Pedersen, Kim O. Gradel
Summary: This study found an association between bacteremia caused by anaerobic bacteria in the gut microbiota and an increased risk of colorectal cancer (CRC) diagnosis. It suggests the need for colorectal workup and the possibility of detecting adenomas or other premalignant conditions.
CLINICAL INFECTIOUS DISEASES
(2022)
Correction
Public, Environmental & Occupational Health
J. E. Coia, J. A. Wilson, A. Bak, G. L. Marsden, M. Shimonovich, H. P. Loveday, H. Humphreys, N. Wigglesworth, A. Demirjian, J. Brooks, L. Butcher, J. R. Price, L. Ritchie, W. Newsholme, D. A. Enoch, J. Bostock, M. Cann, A. P. R. Wilson
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Infectious Diseases
Peter Bager, Jan Wohlfahrt, Samir Bhatt, Marc Stegger, Rebecca Legarth, Camilla Holten Moller, Robert Leo Skov, Palle Valentiner-Branth, Marianne Voldstedlund, Thea K. Fischer, Lone Simonsen, Nikolai Soren Kirkby, Marianne Kragh Thomsen, Katja Spiess, Ellinor Marving, Nicolai Balle Larsen, Troels Lillebaek, Henrik Ullum, Kare Molbak, Tyra Grove Krause
Summary: This study aimed to estimate the risk of hospitalization after infection with the SARS-CoV-2 omicron variant compared with the delta variant in Denmark. The results showed that vaccination was associated with a lower risk of hospitalization, and Omicron infection was associated with a lower risk of hospitalization compared to Delta infection.
LANCET INFECTIOUS DISEASES
(2022)
Article
Microbiology
Viswanath Ragupathy, Mohan Haleyurgirisetty, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Indira Hewlett, Chintamani Atreya
Summary: Despite advances in ensuring blood supply safety, there is still a risk of transfusion transmitted infections (TTIs) from emerging infections. New pathogen reduction technologies (PRTs) using violet-blue light at 405 nm have shown promise in effectively inactivating pathogens in blood, including bacteria, parasites, and viruses.
Article
Infectious Diseases
Mia Torpdahl, Emily Dibba White, Susanne Schjorring, Malene Soby, Jorgen Engberg, Anne Line Engsbro, Hanne M. Holt, Lars Lemming, Lisbeth Lutzen, Bente Olesen, John E. Coia, Charlotte Kjelso, Luise Mueller
Summary: Between November and December 2021, Denmark experienced its first recorded outbreak of enteroinvasive Escherichia coli at a national scale. This report describes the investigation of the outbreak, which was initially identified in early December 2021. The outbreak involved 88 cases, with PCR-based diagnostic methods detecting the infection. However, only 34 cases were confirmed through culture, serotyping, and whole genome sequencing. The outbreak was linked to the consumption of ready-to-eat salads, with imported spring onions as the likely source.
Article
Clinical Neurology
Frederik Novak, Hamza Mahmood Bajwa, John Eugenio Coia, Anna Christine Nilsson, Christian Nielsen, Dorte K. Holm, Kamilla ostergaard, Mathilde Vilhelmine Miller Hvidt, Keld-Erik Byg, Isik S. Johansen, Kristen Mittl, William Rowles, Scott S. Zamvil, Riley Bove, Joseph J. Sabatino, Tobias Sejbaek
Summary: Our study investigated the rate of breakthrough SARS-CoV-2 infection and clinical outcomes in MS patients treated with ocrelizumab before BNT162b2 mRNA vaccinations. Results showed a 59% rate of breakthrough infections after the third vaccination, but without resulting in critical disease courses.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Lucy G. Sinclair, Zornitsa Ilieva, Georgina Morris, John G. Anderson, Scott J. MacGregor, Michelle Maclean
Summary: This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Complete/near-complete inactivation was demonstrated in all cases, with significantly enhanced reductions observed in biologically relevant media. The findings establish the efficacy of low irradiance 405-nm light systems for inactivation of a SARS-CoV-2 surrogate and demonstrate the significant enhancement in susceptibility when suspended in saliva, which is a major vector in COVID-19 transmission.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Infectious Diseases
Anna Tolboll Svendsen, Hans Linde Nielsen, Peter Bytzer, John Eugenio Coia, Jorgen Engberg, Hanne Marie Holt, Lars Lemming, Steen Lomborg, Ea Sofie Marmolin, Bente Scharvik Olesen, Leif Percival Andersen, Steen Ethelberg, Anne Line Engsbro
Summary: In Denmark, bacterial infections are the most common, with viral agents primarily detected in extremes of ages and few intestinal protozoal infections. Incidence rates are influenced by age, clinical setting, and local test methods, with PCR testing resulting in higher detection rates.
INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Eva Plantener, Kumanan Rune Nanthan, Ulrik Deding, Mads Damkjaer, Ea Sofie Marmolin, Lotte Hoeg Hansen, Jens J. H. Petersen, Roberto Pinilla, John E. Coia, Donna Lykke Wolff, Zhijun Song, Ming Chen
Summary: This study evaluated the impact of SARS-CoV-2 restrictions, such as social distancing, on the occurrence of acute gastroenteritis (AGE) among children. Register-based data from three hospitals in Denmark were analyzed, including diagnoses of AGE and analysis of stool samples for AGE-causing pathogens. The study found a significant decrease in AGE-related visits and positive stool samples during the COVID-19 restrictions. Further research is needed to determine the exact factors contributing to this reduction, whether it is due to improved hygiene practices and social distancing or changes in health-seeking behavior among children.
Article
Medical Informatics
Lucy G. Sinclair, Laura R. Dougall, Zornitsa Ilieva, Karen McKenzie, John G. Anderson, Scott J. MacGregor, Michelle Maclean
Summary: This study characterizes the optical output and antibacterial efficacy of a low irradiance 405nm light system for environmental decontamination. The results show that this system has significant inactivation effect on bacteria under laboratory conditions. It has the potential for practical application in infection control.
HEALTH AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Olav Sivertsen Garvik, Pedro Povoa, Pernille Just Vinholt, Stig Lonberg Nielsen, Thoger Gorm Jensen, Henrik Frederiksen, Ming Chen, Ram Benny Dessau, John Eugenio Coia, Jens Kjolseth Moller, Kim Oren Gradel
Summary: The study developed four algorithms for automatic capture of C-reactive protein peaks in patients with acute myeloid leukemia, which detected CRP peaks for BSI episodes and negative blood cultures with high accuracy. The automatic capture of CRP peaks can serve as a tool for monitoring BSI episodes and other infections in these patients.
BIOMARKERS IN MEDICINE
(2023)
Article
Immunology
Ulrik S. Justesen, Stig L. Nielsen, Thoger G. Jensen, Ram B. Dessau, Jens K. Moller, John E. Coia, Steen L. Andersen, Court Pedersen, Kim O. Gradel
Summary: The study indicates that bacteremia with specific gut microbiota anaerobic bacteria is associated with a high risk of colorectal cancer (CRC) diagnosis, highlighting the importance of colorectal workup. This strategy also holds the potential benefit of detecting adenomas or other premalignant conditions.
CLINICAL INFECTIOUS DISEASES
(2022)