Article
Microbiology
Sun Hee Moon, En Huang
Summary: Understanding cefiderocol resistance mechanisms is crucial for developing solutions against infections and resistance development. Cefiderocol resistance in Klebsiella pneumoniae AR 0047 is associated with SHV beta-lactamase activities and loss of the outer membrane porin. The combination of cefiderocol and avibactam presents an opportunity to enhance effectiveness against cefiderocol-resistant pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Andreas G. Tofarides, Panagiotis Dimitriou, Georgios K. Nikolopoulos, Dimitrios Rogkas, Christina Flourou, Elina Khattab, Diamanto Kasapi, Chara Azina, Eirini Christaki
Summary: Klebsiella pneumoniae is a leading cause of hospital-acquired infections, and resistant strains are becoming increasingly common. This study found that recent antimicrobial use and heart disease are associated with bloodstream infections caused by ESBL-producing Klebsiella pneumoniae.
Article
Microbiology
Shirong Li, Siquan Shen, Li Ding, Renru Han, Yan Guo, Dandan Yin, Ming Guan, Fupin Hu
Summary: The prevalence of carbapenem-resistant Klebsiella pneumoniae is increasing, with reports of non-carbapenemase-producing K. pneumoniae showing high-level resistance to carbapenems. In this study, a carbapenemase-negative carbapenem-resistant K. pneumoniae was isolated from a patient, and resistance genes and plasmid transfer were detected. This study reveals the resistance mechanism of this strain.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Mohammad Al-Tamimi, Hadeel Albalawi, Marwan Shalabi, Jumana Abu-Raideh, Ashraf Khasawneh, Farah Alhaj
Summary: This study found a high prevalence of ESBLs among E. coli isolates, with the CTX-M genotype being dominant. The use of CFM and CFM-AMC for ESBL screening and confirmation is an accurate method of detection.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Biotechnology & Applied Microbiology
Heba A. Ahmed, Eman H. S. Ibrahim, Ekram Abdelhaliem, Eman Y. T. Elariny
Summary: This study investigated the frequency, characteristics and antibiotic resistance of nosocomial extended spectrum beta lactamase producing Klebsiella species. The results showed that these Klebsiella pneumoniae strains exhibited resistance to multiple antibiotics and had the ability to form biofilm and produce virulence genes. These resistant strains pose a public threat to hospitalized patients.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Immunology
Dariusz A. Hareza, Sara E. Cosgrove, Patricia J. Simner, Anthony D. Harris, Yehudit Bergman, Rick Conzemius, Emily Jacobs, Stephan Beisken, Pranita D. Tamma
Summary: This study investigated the clinical outcomes and optimal treatment methods for patients with ESBL-E bloodstream infections that do not produce CTX-M. The findings suggest that non-CTX-M and CTX-M ESBL-E infections are equally concerning and associated with similar clinical outcomes. Meropenem may be associated with improved survival in patients with non-CTX-M ESBL-E infections, highlighting the potential benefit of comprehensive molecular diagnostics for early antibiotic optimization in ESBL-E infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Mohammed Almogbel, Ahmed Altheban, Mohammed Alenezi, Khalid Al-Motair, Godfred A. Menezes, Mohammed Elabbasy, Sahar Hammam, John P. Hays, Mushtaq A. Khan
Summary: This study retrospectively characterized E. coli and K. pneumoniae isolates obtained from neonates during a suspected NICU outbreak in Ha'il, Saudi Arabia. The high rate of isolates with simultaneous production of CTX-M-15 and other resistant genes, conferring high-level resistance, is concerning.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Veterinary Sciences
Takeshi Tsuka, Hiroichi Ozaki, Daisuke Saito, Toshiyuki Murase, Yoshiharu Okamoto, Kazuo Azuma, Tomohiro Osaki, Norihiko Ito, Yusuke Murahata, Tomohiro Imagawa
Summary: CTX-M-2-producing Klebsiella oxytoca strains with high ESBL production rates may spread clonally within a farm, while the bla(CTX-M-2) gene in Klebsiella pneumoniae may disseminate among farms through different plasmids. Monitoring ESBL genes, including bla(CTX-M-2), among causative agents of bacterial mastitis in cows can help develop relevant treatments and control practices.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Jose Joao Sumbana, Antonella Santona, Nader Abdelmalek, Maura Fiamma, Massimo Deligios, Alice Manjate, Jahit Sacarlal, Salvatore Rubino, Bianca Paglietti
Summary: Globally, antibiotic-resistant Klebsiella spp. cause healthcare-associated infections with high mortality rates. The study investigated the phenotypic and genetic features of Klebsiella isolates from invasive infections in Mozambique. The majority of isolates displayed multidrug resistance, with ESBL-producing strains carrying various beta-lactamase genes. The study also identified susceptible hypervirulent Klebsiella pneumoniae isolates associated with severe infections. The findings highlight the importance of surveillance strategies to prevent the emergence of multidrug-resistant hypervirulent Klebsiella pneumoniae.
Article
Infectious Diseases
Lei Zha, Xiang Li, Zhichu Ren, Dayan Zhang, Yi Zou, Lingling Pan, Shirong Li, Shanghua Chen, Boris Tefsen
Summary: Based on a retrospective cohort study, piperacillin/tazobactam could be an effective alternative to carbapenems for treating nosocomial pneumonia caused by ESBL-producing K. pneumoniae when the minimum inhibitory concentration (MIC) is <= 8 mg/L.
Article
Microbiology
Cecile Emeraud, Samy Figueiredo, Remy A. Bonnin, Mouna Khecharem, Souad Ouzani, Pierre-Etienne Leblanc, Agnes B. Jousset, Nicolas Fortineau, Jacques Duranteau, Laurent Dortet
Summary: Infections caused by ESBL-KP are on the rise globally and often lead to outbreaks in ICUs. Despite enhanced hygiene measures and prevention controls during the COVID-19 pandemic, an ESBL-producing K. pneumoniae isolate still caused a nosocomial outbreak in an ICU dedicated to COVID-19 patients.
Article
Chemistry, Analytical
Chuchart Pintavirooj, Naphatsawan Vongmanee, Wannisa Sukjee, Chak Sangma, Sarinporn Visitsattapongse
Summary: Nosocomial infection is a significant problem in hospitals, and Klebsiella pneumoniae is a common cause. Researchers developed a MIP-based electrochemical biosensor that can detect K. pneumoniae with high sensitivity, achieving a linear response and low limits of detection and quantitation.
Article
Public, Environmental & Occupational Health
Suhaila A. Al-Sheboul, Ghina S. Al-Madi, Brent Brown, Wail A. Hayajneh
Summary: The prevalence of Klebsiella pneumoniae infections caused by antimicrobial resistance is increasing globally. In this study, K. pneumoniae producing ESBLs were investigated in samples from hematologic malignancy individuals, indicating a high prevalence of ESBL-producing K. pneumoniae.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2023)
Article
Infectious Diseases
Muhammad Mubashar Idrees, Rimsha Rimsha, Muhammad Daoud Idrees, Ali Saeed
Summary: This study investigated the antimicrobial susceptibility of ESBL-producing GNRs and its correlation with corresponding genes. The results showed that these ESBL-producing isolates were resistant to β-lactam and non-β-lactam antibiotics. The prevalence of the bla(CTX-M) gene was high among ESBL-producing GNRs.
Article
Microbiology
Daniela Goncalves, Pedro Cecilio, Alberta Faustino, Carmen Iglesias, Fernando Branca, Alexandra Estrada, Helena Ferreira
Summary: This study highlights the dissemination of IMP-22-producing Klebsiella pneumoniae in the North of Portugal, showing its potential public health threat as it breaches the hospital frontier and spreads to the community. The results suggest both vertical and horizontal dissemination patterns through phenotypic and genotypic characterization, emphasizing the importance of addressing this resistance threat in clinical settings.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Bodo Sahondra Randrianasolo, Peter Mark Jourdan, Pascaline Ravoniarimbinina, Charles Emile Ramarokoto, Fanjasoa Rakotomanana, Vololomboahangy Elisabeth Ravaoalimalala, Svein Gunnar Gundersen, Hermann Feldmeier, Birgitte Jyding Vennervald, Lisette van Lieshout, Borghild Roald, Peter Leutscher, Eyrun Floerecke Kjetland
JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Infectious Diseases
Charles E. Ramarokoto, Fanjasoa Rakotomanana, Maherisoa Ratsitorahina, Vaomalala Raharimanga, Richter Razafindratsimandresy, Rindra Randremanana, Mala Rakoto-Andrianarivelo, Dominique Rousset, Voahangy Andrianaja, Vincent Richard, Jean-Louis Soares, Leon P. Rabarijaona
BMC INFECTIOUS DISEASES
(2008)
Article
Infectious Diseases
Vaomalala Raharimanga, Jean-Francois Carod, Charles-Emile Ramarokoto, Jean-Baptiste Chretien, Fanjasoa Rakotomanana, Antoine Talarmin, Vincent Richard
BMC INFECTIOUS DISEASES
(2008)
Article
Immunology
Peter Derek Christian Leutscher, Charles-Emile Ramarokoto, S. Hoffmann, Jorgen S. Jensen, V. Ramaniraka, B. Randrianasolo, C. Raharisolo, R. Migliani, N. Christensen
CLINICAL INFECTIOUS DISEASES
(2008)
Article
Infectious Diseases
S. Breurec, S. B. Zriouil, C. Fall, P. Boisier, S. Brisse, S. Djibo, J. Etienne, M. C. Fonkoua, J. D. Perrier-Gros-Claude, R. Pouillot, C. E. Ramarokoto, F. Randrianirina, A. Tall, J. M. Thiberge, F. Laurent, B. Garin
CLINICAL MICROBIOLOGY AND INFECTION
(2011)
Article
Infectious Diseases
S. Breurec, C. Fall, R. Pouillot, P. Boisier, S. Brisse, F. Diene-Sarr, S. Djibo, J. Etienne, M. C. Fonkoua, J. D. Perrier-Gros-Claude, C. E. Ramarokoto, F. Randrianirina, J. M. Thiberge, S. B. Zriouil, B. Garin, F. Laurent
CLINICAL MICROBIOLOGY AND INFECTION
(2011)
Article
Infectious Diseases
Jean-Francois Carod, Mickael Randrianarison, Julien Razafimahefa, Rondro Mamitiana Ramahefarisoa, Mahenintsoa Rakotondrazaka, Monique Debruyne, Melanie Dautigny, Pierrette Cazal, Marcellin Lalaoarisoa Andriantseheno, Emile Ramarokoto Charles
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2012)
Article
Virology
Richter Razafindratsimandresy, Jean-Michel Heraud, Charles Emile Ramarokoto, Sendraharimanana Rabemanantsoa, Rindra Randremanana, Nelson Seta Andriamamonjy, Vincent Richard, Jean Marc Reynes
JOURNAL OF MEDICAL VIROLOGY
(2013)
Article
Multidisciplinary Sciences
Rindra Randremanana, Frederique Randrianirina, Marie Gousseff, Natasha Dubois, Richter Razafindratsimandresy, Elisoa Ratsima Hariniana, Benoit Garin, Arthur Randriamanantena, Hanitra Clara Rakotonirina, Lovasoa Ramparany, Charles Emile Ramarokoto, Fanjasoa Rakotomanana, Maherisoa Ratsitorahina, Soatiana Rajatonirina, Antoine Talarmin, Vincent Richard
Article
Infectious Diseases
Frederique Randrianirina, Laetitia Vaillant, Charles Emile Ramarokoto, Armand Rakotoarijaona, Mamy Lalatiana Andriamanarivo, Henri Claude Razafimahandry, Jules Randrianomenjanahary, Jean Roger Raveloson, Elisoa Ratsima Hariniaina, Jean-Francois Carod, Antoine Talarmin, Vincent Richard
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2010)
Article
Infectious Diseases
Charles Emile Ramarokoto, Anna Overgaard Kildemoes, Bodo Sahondra Randrianasolo, Pascaline Ravoniarimbinina, Vololomboahangy Elisabeth Ravaoalimalala, Peter Leutscher, Eyrun Floerecke Kjetland, Birgitte Jyding Vennervald
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Editorial Material
Infectious Diseases
Hermann Feldmeier, Jorg Heukelbach, Uade Samuel Ugbomoiko, Elizabeth Sentongo, Pamela Mbabazi, Georg von Samson-Himmelstjerna, Ingela Krantz
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Tropical Medicine
Angela Schuster, Marlene Thielecke, Vaomalala Raharimanga, Charles Emile Ramarokoto, Christophe Rogier, Ingela Krantz, Hermann Feldmeier
TROPICAL MEDICINE AND HEALTH
(2017)
Article
Virology
Richter Razafindratsimandresy, Audrey Dubot, Charles-Emile Ramarokoto, Catherine Iehle, Jean-Louis Soares, Dominique Rousset
JOURNAL OF MEDICAL VIROLOGY
(2007)