Article
Microbiology
Jincao Hu, Jia Li, Chang Liu, Yan Zhang, Hui Xie, Chuchu Li, Han Shen, Xiaoli Cao
Summary: The characteristics of global beta-lactamase-producing Enterobacter cloacae, including distribution of beta-lactamase, sequence types (STs), and plasmid replicons, were analyzed. Almost all E. cloacae strains carried beta-lactamase encoding genes, with bla(CMH) and bla(ACT) being the most predominant bla(AmpC) genes. Various genotypes of carbapenem-hydrolyzing beta-lactamase (CH β Ls) were identified, with bla(VIM) and bla(KPC) being the most dominant. Diverse STs and plasmid replicons were also identified.
Article
Microbiology
Qipeng Cheng, Zhiwei Zheng, Lianwei Ye, Sheng Chen
Summary: The discovery of a multidrug-resistant Vibrio alginolyticus isolate producing a novel metallo-beta-lactamase VAM-1 from a shrimp sample indicates the potential role of marine organisms as natural reservoirs for MBL genes. Additionally, the study highlights the importance of continuous surveillance of bacterial antibiotic resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Tripti Misra, Meghana Tare, Prabhat Nath Jha
Summary: This study provides a detailed characterization of the biofilm formation process of E. cloacae SBP-8 on different surfaces. The results show that medical devices are highly colonized by this bacterium. The study also investigates the formation and composition of the biofilm using microscopy and spectroscopic techniques.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Shan Jiang, Xiaoyu Wang, Haidong Yu, Jisheng Zhang, Jianmin Wang, Jie Li, Xinhui Li, Kewang Hu, Xue Gong, Xuemei Gou, Yang Yang, Chunjiang Li, Xiaoli Zhang
Summary: Carbapenem-resistant Enterobacter cloacae complex (CRECC) has become a major cause of healthcare-associated infections, and colistin is a last-resort treatment option. Mobile colistin resistance (mcr)-9 gene has been identified in CRECC strains, and its co-location with bla(NDM-1) or bla(IMP-4) has been observed. These findings provide insights into the regulatory mechanisms of mcr-9 expression and emphasize the importance of monitoring the prevalence of co-existing plasmids carrying MBL and mcr-9.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Cristina Lasarte-Monterrubio, Paula Guijarro-Sanchez, Juan Carlos Vazquez-Ucha, Isaac Alonso-Garcia, Laura Alvarez-Fraga, Michelle Outeda, Marta Martinez-Guitian, Andrea Pena-Escolano, Romina Maceiras, Emilio Lence, Concepcion Gonzalez-Bello, Jorge Arca-Suarez, German Bou, Alejandro Beceiro
Summary: Resistance to cefiderocol has emerged among carbapenemase-producing Enterobacterales, particularly in the Enterobacter cloacae complex. This resistance is mainly due to the production of VIM-1 carbapenemase and may also involve the co-production of SHV-12 and inactivation of the FcuA-like siderophore receptor.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Zhiyong Zong, Yu Feng, Alan McNally
Summary: Enterobacter is a globally important pathogen with resistance to carbapenem and colistin. Further research is needed to understand colistin heteroresistance and the emergence of certain Enterobacter lineages clinically.
TRENDS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Konstantina Gartzonika, Lida Politi, Angeliki Mavroidi, Andreas G. Tsantes, Nicholas Spanakis, Efthalia Priavali, Georgia Vrioni, Athanasios Tsakris
Summary: This study describes the epidemiological and molecular characteristics of a large-scale outbreak of NDM-1-producing Enterobacter cloacae complex in Greece, which is the largest clonal outbreak of its kind in Europe. The presence of NDM-1 gene was confirmed in the isolates and it was found to be associated with other resistance genes through genetic sequencing.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Mariana Castanheira, Jill Lindley, Timothy B. Doyle, Andrew P. Davis, Helio S. Sader
Summary: Five Enterobacter cloacae isolates were exposed to cefepime, meropenem, or ceftazidime-avibactam through serial passage in broth microdilution. The study evaluated the increase in minimum inhibitory concentration (MIC) and resistance mechanisms in post-exposure isolates. The results showed diverse mechanisms of resistance and higher MIC values for cefepime and meropenem compared to ceftazidime-avibactam.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Djahida Souna, Mourad Drissi, Iyad Almahmoud, Max Maurin
Summary: This study evaluated beta-lactam resistance in Enterobacter cloacae complex strains isolated from Algerian hospitals, with the majority identified as Enterobacter hormaechei species, particularly the subspecies E. hormaechei subsp. xiangfangensis. All strains exhibited resistance to multiple antibiotics and were found to produce ESBLs, primarily from the CTX-M-1 group, notably CTX-M-15. The identification and management of multidrug-resistant ECC strains, particularly those carrying CTX-M ESBLs, pose a significant public health challenge in Algeria.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Food Science & Technology
Rasiravathanahalli Kaveriyappan Govindarajan, Chartchai Khanongnuch, Krishnamurthy Mathivanan, Douglas J. H. Shyu, Kanti Prakash Sharma, Surajit De Mandal
Summary: This study demonstrates that tannase enzyme treatment can reduce the formation of tea cream, improve the antioxidant activity of black tea, and enhance the sensory characteristics of tea. The results suggest that the tannase produced by E. cloacae 41 could be utilized to enhance the quality of both CTC and Kangra orthodox tea samples.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Infectious Diseases
Cecile Emeraud, Caroline Petit, Lauraine Gauthier, Remy A. Bonnin, Thierry Naas, Laurent Dortet
Summary: This study genetically characterized VIM-producing Enterobacter cloacae complex (ECC) isolates recovered in France from 2015 to 2018. The prevalence of ECC among VIM-producing Enterobacterales increased significantly during this period. Various species and sequence types were identified among these isolates. Additionally, different integrons carrying specific bla(VIM) variants were identified.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Aparna Nair, Renuka Vyawahare, Krishna Khairnar
Summary: The novel bacteriophage En5822 isolated from the environment shows high lytic activity, specificity, and biofilm reduction capability against Enterobacter cloacae. Its genomic and physical attributes make it a potential alternative antimicrobial for treating drug-resistant infections.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Dennis Nurjadi, Kaan Kocer, Quan Chanthalangsy, Sabrina Klein, Klaus Heeg, Sebastien Boutin
Summary: This study found that the emergence of resistance to Cefiderocol in metallo-beta-lactamase-producing bacteria is facilitated by mutations in the CirA siderophore receptor, which are induced by the New Delhi metallo-beta-lactamase. However, inhibiting the metallo-beta-lactamase activity using dipicolinic acid can successfully prevent the development of Cefiderocol-resistant mutants. Therefore, caution should be taken when using Cefiderocol to treat infections caused by metallo-beta-lactamase-producing bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Shengnan Hu, Wenyan Xie, Qiwen Cheng, Xiaoning Zhang, Xiutao Dong, Huaiqi Jing, Jiazheng Wang
Summary: This study investigated the prevalence and characteristics of carbapenem-resistant Enterobacter cloacae complex (CREC) isolates in a tertiary hospital in Shandong, China. The most common carbapenemases detected were NDM-5 and NDM-1. These findings provide valuable information for infection control and treatment in hospitals.
Article
Microbiology
Yiping Wu, Ruowen He, Mingyang Qin, Yanxian Yang, Jieyun Chen, Yu Feng, Xiaoxue Liang, Wenbin Deng, Xin Ding, Li-Na Qin, Kang Liao, Yongqiang Yang, Guo-Bao Tian
Summary: We identified two tet(X4)-positive E. cloacae isolates and found that the pTECL_2-190k-tetX4-like plasmid has been widely disseminated across various species of Enterobacteriaceae. By analyzing 85 tet(X4)-carrying plasmids, we determined that these plasmids have multiple replicon types, including IncFIA, IncHI1A, and IncHI1B.
MICROBIOLOGY SPECTRUM
(2022)
