Article
Chemistry, Physical
Xiao-Lian Wang, Li-Tian Zhang, Shan He, Xiao-Xian Chen, Xiao-Chun Huang, Hao-Long Zhou
Summary: Covalent organic frameworks (COFs) are a class of crystalline porous materials with promising applications. However, the lack of an efficient and scalable synthesis protocol hinders their further application. This study proposes a synthesis method based on dynamic covalent chemistry, using imine exchange reactions, to rapidly prepare high-quality COFs with desirable structures.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemical Research Methods
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Jonathan D. Tyzack, Neera Borkakoti, Janet M. Thornton
Summary: The rich literature on enzyme reaction mechanisms can serve as the foundation for new knowledge-based approaches to investigate enzyme mechanisms. In this study, a tool called EzMechanism is presented, which can automatically infer mechanistic paths for a given three-dimensional active site and enzyme reaction based on catalytic rules compiled from a database of enzyme mechanisms. EzMechanism facilitates and improves the generation of hypotheses by considering relevant information derived from literature on both related and unrelated enzymes.
Article
Chemistry, Multidisciplinary
Davide Arnodo, Federica De Nardi, Stefano Parisotto, Eugenio De Nardo, Stefania Canana, Federica Salvatico, Elisa De Marchi, Dina Scarpi, Marco Blangetti, Ernesto G. Occhiato, Cristina Prandi
Summary: The enantioselective reduction of 2-substituted cyclic imines to corresponding amines using imine reductases in non-conventional solvents has been reported. The method achieved high conversions, moderate to good yields, and excellent enantioselectivities. A fed-batch protocol was developed for scale-up transformation, resulting in efficient production of enantiopure amines.
Review
Chemistry, Multidisciplinary
Graziano Di Carmine, Andrew P. Abbott, Carmine D'Agostino
Summary: Deep eutectic solvents (DES) are emerging as an alternative to ionic liquids (ILs) due to their low vapor pressure, capability to dissolve reagents insoluble in common organic solvents, and the possibility to tune the overall pH of the medium by replacing one of the constituents of the mixture. DES can be prepared by combining molecules from natural sources and have the ability to dissolve both organic lipophilic and hydrophilic species, making them efficient in organic oxidation reactions.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Yusen Li, Linshuo Guo, Yongkang Lv, Ziqiang Zhao, Yanhang Ma, Weihua Chen, Guolong Xing, Donglin Jiang, Long Chen
Summary: The study designed and synthesized different isomeric tetraphenyl benzene monomers to construct various frameworks by changing reaction solvents. The geometry of monomers was found to influence lattice growth process, with the frameworks exhibiting highly selective adsorption of vitamin B-12.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jennifer Noro, Joana Cabo, David S. Freitas, Catarina S. Roque, Mariana de Castro, Artur Cavaco-Paulo, Carla Silva
Summary: In this study, three deep eutectic mixtures (DES) were used as mediums to synthesize glucose laurate and glucose acetate. Lipases from Aspergillus oryzae (LAO), Candida rugosa (LCR), and porcine pancreas (LPP) were employed as catalysts. The results showed that DES did not deactivate the lipases when used as medium. For transesterification reactions, combining LAO or LCR with DES 3 resulted in efficient production of glucose laurate, while LPP performed best in DES 2 for glucose acetate synthesis. Substituting vinyl laurate with vinyl acetate led to different behaviors, with LCR and LPP showing better catalytic activity in DES 1 for glucose acetate production. LAO had lower activity, with only around 40% product yield in DES 3. These findings highlight the potential of biocatalysis combined with greener solvents for the synthesis of differentiated sugar fatty acid esters.
Article
Chemistry, Multidisciplinary
Satomi Niwayama, Yoshikazu Hiraga
Summary: Water-mediated organic reactions play a significant role in environmental protection. Desymmetrization reactions are cost-effective due to the low cost of starting materials and have been previously reported to be highly efficient and practical in selective monohydrolysis reactions of symmetric diesters. The mechanisms of these reactions are hypothesized to proceed through micellar aggregates that govern the high selectivities by directing hydrophilic carboxylate anions outward and hydrophobic groups inward.
Article
Engineering, Environmental
Elien Laforce, Ingeborg Stals, Emile R. Cornelissen, Pieter Vermeir, Jeriffa De Clercq
Summary: This study aimed to provide in-depth insights into the removal of natural organic matter (NOM) using different types of anion exchange resins (AER). The results demonstrated that the resin conditioning procedure and the corresponding counter ion form played a key role in the efficiency and mechanisms of NOM removal.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Annemieke van Dam, Robin van Schendel, Satesh Gangarapu, Han Zuilhof, Maarten M. J. Smulders
Summary: The coordination of Fe2+ ion greatly lowers the activation energy and catalyzes the condensation and transimination reactions of imine. The nature of incoming and exiting amines and the substituents on the para-position of the pincer have no significant effect on the reaction. However, the addition of ethylamine molecules reduces the energy barriers to be compatible with experimental values.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Environmental
Thomas Moore, Guanhe Rim, Ah-Hyung Alissa Park, A. Kathryn Mumford, W. Geoffrey Stevens, A. Paul Webley
Summary: The encapsulation of highly viscous liquid-like Nanoparticle Organic Hybrid Materials (NOHMs) inside a gas permeable polymer to form SIPs significantly enhanced the CO2 capture kinetics. The diffusion-controlled model was used to simulate CO2 uptake within the hybrid materials, showing that the increase in gas flux was a consequence of the very large CO2 permeability within the polymer-solvent composite.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Mohammad Taghi Nazeri, Maryam Ghasemi, Masoomeh Ahmadi, Ahmad Shaabani, Behrouz Notash
Summary: By employing triazolobenzodiazepine as a cyclic imine, a variety of compounds can be synthesized under different reaction conditions, with mild conditions and high yields.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Linqing Wang, Dongxu Yang
Summary: In this article, the researchers focus on the reactions initiated by the N-nucleophilicity of imines, especially cyclization reactions. They briefly discuss the N-nucleophilicity of different imines, possible mechanisms, catalytic strategies, and reaction types. The researchers hope that imines, as one of the basic chemical synthons in organic synthesis, will be utilized more extensively in the future by taking advantage of their N-nucleophilicity.
Review
Chemistry, Inorganic & Nuclear
Javier Marti-Rujas, Fang Guo
Summary: The article reports on the latest advances in solid-state dehydrohalogenation and halogenation reactions focusing on the second sphere coordination perspective. The study emphasizes outer sphere adducts where protonated organic cations act as hydrogen bond donors and transition metal anions act as hydrogen bond acceptors. The transformations from second sphere coordination to first sphere coordination are induced by external stimuli and reveal a unique solid-state chemistry and reactivity.
DALTON TRANSACTIONS
(2021)
Article
Nanoscience & Nanotechnology
Marco Moroni, Esther Roldan-Molina, Rebecca Vismara, Simona Galli, Jorge A. R. Navarro
Summary: This study focuses on the impact of pore flexibility in covalent organic frameworks (COFs) on the adsorption and separation of benzene and cyclohexane. The results show that COF-300 has better adsorption and separation performance than LZU-111.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xiaomin Li, Junyi Wang, Fengfeng Xue, Yichen Wu, Hualong Xu, Tao Yi, Qiaowei Li
Summary: A new metal-organic framework (MOF) with both coordination and covalent linkages has been prepared, demonstrating high efficiency in decomposing H2O2 and exciting O-2 to generate reactive oxygen species, showing effective photosensitizing activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)