期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 12, 页码 3691-3698出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob00147a
关键词
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Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones' cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90's C-terminus, when used in combination with Hsp70 inhibitors, produces a synergistic and highly relevant dual chemotherapy regimen.
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