期刊
JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 49, 期 5, 页码 1136-1142出版社
WILEY
DOI: 10.1002/jhet.969
关键词
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资金
- National Basic Research Program of China (973 Program) [2010CB126100]
- National High Technology Research and Development Program of China (863 Program) [2010AA10A204]
- National Natural Science Foundation of China [21002030, 2087203]
- Natural Science Foundation of Shanghai [10ZR1407300]
- Fundamental Research Funds for the Central Universities
- Shanghai Leading Academic Discipline Project [B507]
The chlorothiazolyl moiety was an effective bioisoster of chloropyridyl in pesticide molecular design. Replacement of chloropyridyl in cis-nitromethylene neonicotinoids with chlorothiazolyl generated the chlorothiazolyl counterpart of nitromethylene neonicotinoids with tetrahydropyridine fixed cis-configuration. Bioassay against cowpea aphis (Aphis craccivora) indicated that the chlorothiazolyl analogs could maintain the high insecticidal activity.
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