Article
Clinical Neurology
Keith R. Macgregor, Timothy J. Hartman, James W. Nie, Eileen Zheng, Omolabake O. Oyetayo, Dustin H. Massel, Arash J. Sayari, Kern Singh
Summary: This study assessed the correlation between patient-reported mental health and physical function, pain, and disability following disc replacement surgery. The results showed that patients with lower mental health scores reported higher levels of pain and disability. Mental health was consistently associated with disability level at all time points.
ACTA NEUROCHIRURGICA
(2023)
Article
Rheumatology
Clifton O. Bingham, David Walker, Peter Nash, Susan J. Lee, Lei Ye, Hao Hu, Javaria Mona Khalid, Bernard Combe
Summary: This study investigated the effects of Filgotinib on patient-reported outcomes (PROs) in patients with active rheumatoid arthritis. The results showed that Filgotinib improved symptoms, quality of life, and work productivity in different patient populations.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Oncology
Fan Yang, Sunita Ghosh, Don Yee, Samir Patel, Nadeem Pervez, Matthew Parliament, Nawaid Usmani, Brita Danielson, John Amanie, Robert Pearcey, Colin Field, Gino Fallone, Albert Murtha
Summary: This study compares the patient-reported quality of life (QoL) outcomes between conventional and hypofractionated radiation therapy in the treatment of high-risk prostate cancer. The results show no major differences in QoL between the two groups at 24 months post-treatment, with early statistically significant differences in bowel bother and SF-12 physical component scores no longer present.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Psychiatry
Paul H. Lysaker, Peter J. Weiden, Xiaowu Sun, Amy K. O'Sullivan, Joseph P. McEvoy
Summary: This study examined the relationship between insight impairment and patient-reported mental health status, depression, and neurocognition in patients with schizophrenia. The results showed that more severe insight impairment was associated with better patient-reported quality of life, lower baseline depression, and greater discrepancy between patient and physician ratings of illness severity. However, this effect was not observed in patients with normal to moderately impaired insight, suggesting that poor insight does not commonly affect the validity of self-report.
Article
Multidisciplinary Sciences
Mustapha Thaim Buya Kamara, Veronica L. Richards, Charurut Somboonwit, Haesuk Park, Nana Ayegua Hagan Seneadza, Zhou Zhi, Dushyantha Jayaweera, Emmanuel Thomas, Robert L. Cook
Summary: The study found that participants aged 55 and above, drug users (both injection and non-injection), and individuals with education beyond high school were more likely to have undergone HCV testing. However, the testing rate for HCV was lower among individuals aged 18-34, with lower education levels, and non-Hispanic Blacks.
Article
Immunology
Hirokazu Kanegane, Masataka Ishimura, Toshinao Kawai, Satoshi Okada, Nobuaki Okamatsu, Madoka Go, Shinichi Noto
Summary: This study aims to evaluate the disease activity, treatment status, treatment-related burden, daily activities, and HR-QOL in patients with PID in Japan. The findings indicate that patients with PID in Japan have lower HR-QOL and work productivity compared to healthy individuals and experience substantial limitations and burdens in their daily lives.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ellison Suthoff, Mark Kosinski, Alix Arnaud, Paul Hodgkins, Handan Gunduz-Bruce, Robert Lasser, Christopher Silber, Abdul J. Sankoh, Haihong Li, Brian Werneburg, Jeffrey Jonas, James Doherty, Stephen J. Kanes, Vijayveer Bonthapally
Summary: This study aimed to assess the impact of the neuroactive steroid zuranolone on health-related quality of life (HRQoL) in patients with major depressive disorder (MDD) using the SF-36v2 survey. The results showed that patients treated with zuranolone reported improvements in HRQoL across multiple domains and summary scores, and these improvements were correlated with clinician-rated assessments.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Edwin de Beurs, Ingrid Carlier, Albert van Hemert
Summary: The study compared treatment outcomes on the BSI and the SF-36 in a sample of 13,423 outpatients with common psychiatric disorders, finding that the two instruments were associated but did not measure the same underlying construct. The SF-36 provided a broader clinical picture of individual patients, especially in terms of mental health outcomes, making it a valuable addition to treatment evaluation alongside the BSI.
QUALITY OF LIFE RESEARCH
(2022)
Article
Rheumatology
Andrew J. K. Ostor, Ahmed M. Soliman, Kim A. Papp, Byron Padilla, Zailong Wang, Ann Eldred, Kurt de Vlam, Alan Kivitz
Summary: The study found that treatment with risankizumab resulted in significant improvements in pain, fatigue, health-related quality of life, and work ability in patients with psoriatic arthritis who had inadequate response to one or two biologics and/or one or more conventional synthetic disease-modifying antirheumatic drugs.
Article
Orthopedics
Anders Odgaard, Andreas Kappel, Frank Madsen, Per Wagner Kristensen, Snorre Stephensen, Amir Pasha Attarzadeh
Summary: This study compared the PRO improvements in patients undergoing PFA and TKA for isolated PF-OA, finding that patients undergoing PFA showed better improvement in pain, physical function, symptoms, and sports/recreation aspects over 6 years. However, at the 6-year follow-up, no consistent differences in outcomes were observed.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Rheumatology
Rebecca Williams-Hall, Pamela Berry, Nicola Williamson, Melissa Barclay, Anna Roberts, Adam Gater, Chloe Tolley, Helena Bradley, Amy Ward, Elizabeth Hsia, Qing Zuraw, Patricia DeLong, Zahi Touma, Vibeke Strand
Summary: This study evaluated the content validity of patient-reported outcomes (PROs) commonly used in SLE and LN, as well as novel PRO symptom severity items. The findings showed that the concepts assessed by SF-36, FACIT-F, LupusQoL, and the novel PRO symptom severity items were well understood and relevant by the participants. These results support the use of these PROs in future SLE and LN clinical trials to comprehensively assess disease impact.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Oncology
Maria Rothmund, Micha J. J. Pilz, Nathalie Egeter, Emma Lidington, Claire Piccinin, Juan I. I. Arraras, Mogens Gronvold, Bernhard Holzner, Marieke van Leeuwen, Morten Aa. Petersen, Heike Schmidt, Teresa Young, Johannes M. M. Giesinger, EORTC Quality Life Grp
Summary: This study compared the content of commonly used patient-reported outcome measures (PROMs) and found that they cover 132 unique items primarily focusing on emotional functioning, with the majority of items falling under the third-level category of "emotional functions, other specified".
Article
Clinical Neurology
Dhruv K. C. Goyal, Srikanth N. Divi, Daniel R. Bowles, Victor E. Mujica, I. David Kaye, Mark F. Kurd, Barrett I. Woods, Kris E. Radcliff, Jeffrey A. Rihn, D. Greg Anderson, Alan S. Hilibrand, Christopher K. Kepler, Alexander R. Vaccaro, Gregory D. Schroeder
Summary: This retrospective cohort study aimed to determine the influence of smoking status on patient-reported outcome measurements in lumbar decompression surgery patients. The study found that smoking status did not significantly affect short-term complications or outcomes in patients undergoing this surgery.
GLOBAL SPINE JOURNAL
(2021)
Article
Substance Abuse
Aaron Guanliang Lim, Christer Frode Aas, Ege Su Caglar, Jorn Henrik Vold, Lars Thore Fadnes, Peter Vickerman, Kjell Arne Johansson
Summary: The INTRO-HCV trial in Norway showed that integrated treatment with direct-acting antivirals (DAAs) improved outcomes for people who inject drugs (PWID) with hepatitis C virus (HCV). This study evaluated the cost-effectiveness of the INTRO-HCV intervention using a Markov model and found that the integrated treatment was likely cost-effective and potentially cost-saving with price reductions of DAAs. The findings suggest that integrated HCV treatment in community settings is a valuable option for PWID.
Article
Health Care Sciences & Services
Caspar Wiegmann, Esther Quinlivan, Twyla Michnevich, Andreas Pittrich, Petja Ivanova, Alissa Maresa Rohrbach, Jakob Kaminski
Summary: The effective treatment of patients with severe psychiatric disorders relies on subjective reporting of symptoms and side-effects, which can lead to uncertainty and non-adherence. In this study, a flexible electronic patient-reported outcome (ePRO) system was developed to allow patients to record and share their symptoms, improving outcomes and potentially reducing health service costs. Input from patients, practitioners, digital health experts, software engineers, and researchers was incorporated in the development process, leading to a trial-ready ePRO system for severe psychiatric disorders.
Article
Microbiology
Leonardo Nieto-Aponte, Josep Quer, Alicia Ruiz-Ripa, David Tabernero, Carolina Gonzalez, Josep Gregori, Marta Vila, Miriam Asensio, Damir Garcia-Cehic, Gerardo Ruiz, Qian Chen, Laura Ordeig, Meritxell Llorens, Montserrat Saez, Juan I. Esteban, Rafael Esteban, Maria Buti, Tomas Pumarola, Francisco Rodriguez-Frias
JOURNAL OF CLINICAL MICROBIOLOGY
(2017)
Review
Gastroenterology & Hepatology
J. Llaneras, M. Riveiro-Barciela, M. Buti, R. Esteban
JOURNAL OF VIRAL HEPATITIS
(2017)
Article
Gastroenterology & Hepatology
S. Alonso, M. Riveiro-Barciela, I. Fernandez, D. Rincon, Y. Real, S. Llerena, F. Gea, A. Olveira, C. Fernandez-Carrillo, B. Polo, J. A. Carrion, A. Gomez, M. J. Devesa, C. Baliellas, A. Castro, J. Ampuero, R. Granados, J. M. Pascasio, A. Rubin, J. Salmeron, E. Badia, J. M. M. Planas, S. Lens, J. Turnes, J. L. Montero, M. Buti, R. Esteban, C. M. Fernandez-Rodriguez
JOURNAL OF VIRAL HEPATITIS
(2017)
Article
Biotechnology & Applied Microbiology
Laura Ordeig, Damir Garcia-Cehic, Josep Gregori, Maria Eugenia Soria, Leonardo Nieto-Aponte, Celia Perales, Meritxell Llorens, Qian Chen, Mar Riveiro-Barciela, Maria Buti, Rafael Esteban, Juan Ignacio Esteban, Francisco Rodriguez-Frias, Josep Quer
JOURNAL OF GENERAL VIROLOGY
(2018)
Article
Gastroenterology & Hepatology
M. Hedenstierna, A. Nangarhari, A. El-Sabini, O. Weiland, S. Aleman
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Martin Kaberg, Georg Naver, Anders Hammarberg, Ola Weiland
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Maria Buti, Mar Riveiro-Barciela, Rafael Esteban
LIVER INTERNATIONAL
(2018)
Article
Virology
Sara Sopena, Cristina Godoy, David Tabernero, Maria Homs, Josep Gregori, Mar Riveiro-Barciela, Alicia Ruiz, Rafael Esteban, Maria Buti, Francisco Rodriguez-Frias
Article
Gastroenterology & Hepatology
Rosario Casillas, David Tabernero, Josep Gregori, Irene Belmonte, Maria Francesca Cortese, Carolina Gonzalez, Mar Riveiro-Barciela, Rosa Maria Lopez, Josep Quer, Rafael Esteban, Maria Buti, Francisco Rodriguez-Frias
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Review
Infectious Diseases
Martin Lagging, Rune Wejstal, Ann-Sofi Duberg, Soo Aleman, Ola Weiland, Johan Westin
INFECTIOUS DISEASES
(2018)
Article
Multidisciplinary Sciences
Maria Buti, Maria L. Manzano, Rosa M. Morillas, Montserrat Garcia-Retortillo, Leticia Martin, Martin Prieto, Maria L. Gutierrez, Emilio Suarez, Mariano Gomez Rubio, Javier Lopez, Pilar Castillo, Manuel Rodriguez, Jose M. Zozaya, Miguel A. Simon, Luis E. Morano, Jose L. Calleja, Maria Yebenes, Rafael Esteban
Article
Gastroenterology & Hepatology
Steven Flamm, David Mutimer, Armen Asatryan, Stanley Wang, Jurgen Rockstroh, Yves Horsmans, Paul Y. Kwo, Ola Weiland, Erica Villa, Jeong Heo, Edward Gane, Stephen D. Ryder, Tania M. Welzel, Peter J. Ruane, Kosh Agarwal, Teresa Ng, Zhenyi Xue, Sandra S. Lovell, Preethi Krishnan, Sarah Kopecky-Bromberg, Roger Trinh, Federico J. Mensa, David L. Wyles
JOURNAL OF VIRAL HEPATITIS
(2019)
Article
Gastroenterology & Hepatology
Peter Lindgren, Sofia Lofvendahl, Gunnar Bradvik, Ola Weiland
Summary: The study investigated the impact of new drugs on sick leave and found that second-generation DAAs can reduce the number of sick days compared to older treatments. However, caution is advised in interpreting the results due to potential heterogeneity between cohorts treated at different points in time.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Economics
Peter Lindgren, Sofia Lofvendahl, Gunnar Bradvik, Ola Weiland, Bengt Jonsson
Summary: The Swedish government allocated funds for new drugs for hepatitis C, leading to significant social surplus primarily from QALY gains and reduced indirect costs as prices dropped. As eligibility criteria were loosened, QALY gains did not increase as rapidly as the number of treated patients.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Infectious Diseases
F. Rodriguez-Frias, L. Nieto-Aponte, J. Gregori, D. Garcia-Cehic, R. Casillas, D. Tabernero, M. Homs, M. Blasi, M. Vila, Q. Chen, V. Vargas, Ll. Castells, Ll. Viladomiu, J. Genesca, B. Minguez, S. Augustin, M. Riveiro-Barciela, J. Carbonell, C. Perales, M. E. Soria, M. Asensio, M. Llorens, L. Ordeig, C. Godoy, M. Buti, R. Esteban, T. Pumarola, J. I. Esteban, J. Quer
CLINICAL MICROBIOLOGY AND INFECTION
(2017)