Article
Medicine, General & Internal
Yan-zhong Han, Yu-ming Guo, Peng Xiong, Fei-lin Ge, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Hai-bo Song, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that the aging population is more susceptible to liver-related ADRs, with the relative risk increasing exponentially with age. It is important to address risk management for older adults when using drugs with a high correlation to the risk of ADRs.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Allison Cid, Megan E. Smetana, Courtney Hebert, Kelci Coe, Jessica M. Smith
Summary: The aim of this study was to evaluate the effect of concomitant use of fluconazole and direct oral anticoagulants (DOACs) on bleeding risk. The study found that patients receiving a DOAC with fluconazole did not have a significantly increased risk for bleeding at 30 days compared to those receiving a DOAC alone after adjusting for confounding variables.
Article
Pharmacology & Pharmacy
Long Meng, Jing Huang, Feng Qiu, Xuefeng Shan, Lin Chen, Shusen Sun, Yuwei Wang, Junqing Yang
Summary: The study identified an association between the combined use of proteasome inhibitors (PI) and factor Xa inhibitors (FXaI) leading to an increased reporting of peripheral neuropathy (PN) through analysis of FAERS data. Further preclinical and clinical studies are needed to elucidate this relationship.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yamin Shu, Jing Chen, Yiling Ding, Qilin Zhang
Summary: This study evaluated risankizumab-associated adverse events (AEs) and characterized the clinical priority through data mining of the FDA Adverse Event Reporting System (FAERS). The study found potential new AE signals and provided valuable evidence for clinicians to mitigate the risk of risankizumab-associated AEs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mingming Li, Ruxu You, Yuyong Su, Hongbo Zhou, Shiwei Gong
Summary: Tumor necrosis factor (TNF) inhibitors have greatly improved the treatment of severe immune-mediated inflammatory diseases. This study analyzed adverse drug reactions (ADRs) of five TNF inhibitors using data from the WHO's VigiAccess database, aiming to identify the drug with the lowest risk for individualized patient use.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kristopher Amaro-Hosey, Immaculada Danes, Antonia Agusti
Summary: A systematic review revealed a high incidence of ADR in pediatric oncohematology patients, along with significant variability in study design and results. Enhancing methodological standards and preventability assessment is crucial for result comparison and identifying areas for improvement in future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
N. E. Omar, A. I. Fahmy Soliman, M. Eshra, T. Saeed, A. Hamad, A. Abou-Ali
Summary: Analysis of FAERS data revealed significant safety signals for several ALK inhibitors, including risks related to eye disorders, respiratory disorders, and metabolism disorders. Further regulatory investigation is needed to verify the significance of these signals and potentially update product labels.
Article
Pharmacology & Pharmacy
Nayara Aparecida de Oliveira-Silva, Albert Figueras, Daniela Oliveira de Melo
Summary: Reports from the Food and Drug Administration Adverse Event Reporting System (FAERS) Public Dashboard showed that the use of drugs such as tocilizumab, remdesivir, hydroxychloroquine, and/or lopinavir/ritonavir for treating COVID-19 can increase the risk of liver events. The reported odds ratios (ROR) indicated a higher risk of liver events in COVID-19 patients compared to uninfected patients.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Agne Valinciute-Jankauskiene, Kubiliene Loreta
Summary: The study found that patients were able to identify ADRs and used different information sources about medicines and ADRs to confirm their beliefs. However, poor communication between consumers, pharmacists, and physicians is the main barrier to ADR reporting. This study identified the challenges in relation to pharmacovigilance in Lithuania from patients' perspectives, indicating a lack of clearly set standards and communication guidelines between patients, physicians, and pharmacists.
Review
Public, Environmental & Occupational Health
Joel Fossouo Tagne, Reginald Amin Yakob, Thu Ha Dang, Rachael Mcdonald, Nilmini Wickramasinghe
Summary: Despite existing national and international guidelines, there is significant variability in the standards of adverse drug reaction (ADR) reporting among healthcare facilities. There is room for improvement in ADR reporting rates among consumers and healthcare professionals. A thorough assessment of barriers and enablers to ADR reporting at the primary healthcare level is necessary, and interventions such as the black triangle scheme and GuildLink may benefit from further improvement and awareness programs.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Pharmacology & Pharmacy
Monica Valdes-Garicano, Gina Mejia-Abril, Diana Campodonico, Raul Parra-Garces, Francisco Abad-Santos
Summary: This study evaluated the performance of a laboratory alerts system as a method for detecting adverse drug reactions (ADRs) using hyponatremia and rhabdomyolysis as case studies. The results showed that a pharmacovigilance program based on automatized laboratory signals could effectively detect ADRs, and the study of the hyponatremia laboratory alert was found to be more efficient than rhabdomyolysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kristopher Amaro-Hosey, Immaculada Danes, Lourdes Vendrell, Laura Alonso, Berta Renedo, Luis Gros, Xavier Vidal, Gloria Cereza, Antonia Agusti
Summary: This study found that adverse drug reactions (ADR) are common in pediatric oncohematological patients, mainly involving blood disorders and infections. Most ADR were dose-dependent or expected, and controversial additional prevention measures were identified.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lara Magro, Elena Arzenton, Roberto Leone, Marilisa Giustina Stano, Michele Vezzaro, Annette Rudolph, Irene Castagna, Ugo Moretti
Summary: The study found that about one-third of patients exposed to potential drug-drug interactions actually experienced serious adverse drug reactions, and that a spontaneous reporting database can be used to identify and describe ADRs caused by drug-drug interactions. Among these ADRs, warfarin was the most frequently reported interacting drug and the most common ADRs were gastrointestinal or cerebral hemorrhagic events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Birita Sofia Ellefsen, Kristine Ron Larsen, Jesper Reibel, Camilla Kragelund
Summary: Post-marketing pharmacosurveillance is crucial for minimizing harm to patients from marketed drugs. Oral adverse drug reactions (OADRs) are underreported, and their inclusion in drug summary of product characteristics (SmPC) is limited. The reporting pattern of healthcare professionals is influenced by community debates, professional circles, and drug SmPC information. Systematic, reliable, and consistent reporting is essential to avoid skewed information and all healthcare professionals should be educated to recognize and report suspected adverse drug reactions.
Article
Pharmacology & Pharmacy
Louis Letinier, Amandine Ferreira, Alexandre Marceron, Marina Babin, Joelle Micallef, Ghada Miremont-Salame, Antoine Pariente
Summary: The study found that hemorrhage was the most common clinical manifestation of serious adverse drug reactions resulting from drug-drug interactions reported in France, followed by renal failure, pharmacokinetic alteration, and cardiac arrhythmias. More than one-third of serious adverse drug reactions involved at least three drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Irene Hernandez Lozano, Martin Bauer, Beatrix Wulkersdorfer, Alexander Traxl, Cecile Philippe, Maria Weber, Stephanie Hausler, Bruno Stieger, Walter Jaeger, Severin Mairinger, Thomas Wanek, Marcus Hacker, Markus Zeitlinger, Oliver Langer
MOLECULAR PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Evelin Krajnc, Michele Visentin, Zhibo Gai, Bruno Stieger, Sophia L. Samodelov, Stephanie Hausler, Gerd A. Kullak-Ublick
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Surgery
Dilmurodjon Eshmuminov, Martin J. Schuler, Dustin Becker, Lucia Bautista Borrego, Matteo Mueller, Catherine Hagedorn, Stephanie Haeusler, Julia Steiger, Mark W. Tibbitt, Philipp Dutkowski, Philipp Rudolf von Rohr, Bruno Stieger, Max Hefti, Pierre-Alain Clavien
Summary: This study developed a bile stimulation protocol during long-term ex situ liver perfusion and found that proper administration of stimulators can induce constant bile flow. However, the presence of bile flow alone is not sufficient to assess liver viability.
Review
Biochemistry & Molecular Biology
Bruno Stieger, Julia Steiger, Kaspar P. Locher
Summary: Transport proteins play a crucial role in the exchange of substances between cells and their environment, and they are affected by the specific binding and bulk modulation of membrane lipids. Human diseases that disrupt lipid homeostasis can alter membrane lipid composition and consequently impact the function of transporter proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Pharmacology & Pharmacy
Michele Leuenberger, Stephanie Haeusler, Vera Hoehn, Adriana Euler, Bruno Stieger, Martin Lochner
Summary: Synthetic modification of common bile acids by attaching small organic fluorescent dyes to the bile acid side chain resulted in novel fluorescent probes that interact with hepatic and intestinal organic anion transporters (OATP1B1, OATP1B3, OATP2B1), bile salt uptake transporters (NTCP, ASBT), and bile salt efflux transporters (BSEP, MRP2). Although the fluorescent bile acid derivatives are taken up into cells via the OATPs, the efflux transporters do not transport any of them except one.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Letter
Biochemistry & Molecular Biology
Bruno Hagenbuch, Bruno Stieger
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Kamil Nosol, Rose Bang-Sorensen, Rossitza N. Irobalieva, Satchal K. Erramilli, Bruno Stieger, Anthony A. Kossiakoff, Kaspar P. Locher
Summary: ABCB4 is expressed in hepatocytes and plays a key role in translocating phosphatidylcholine into bile canaliculi. Cryogenic electron microscopy structures of ABCB4 reveal its specificity for phosphatidylcholine and the essential role of key residues in this process. These findings provide a structural basis for understanding bile generation and its sensitivity to azole drugs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Cristina Gomez, Fadi Jebbawi, Michael Weingartner, Junhua Wang, Simon Stuecheli, Bruno Stieger, Bruno Gottstein, Guido Beldi, Britta Lundstroem-Stadelmann, Alex Odermatt
Summary: Alveolar echinococcosis caused by Echinococcus multilocularis is a chronic liver disease affecting the Northern Hemisphere. Treatment options include surgery and benzimidazole albendazole. This study utilized LC-MS/MS to analyze bile acid profiles in a mouse model and found potential serum markers for AE.
Biographical-Item
Gastroenterology & Hepatology
Bruno Stieger, James L. Boyer
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell Biology
Benjamin P. Luescher, Christiane Albrecht, Bruno Stieger, Daniel V. Surbek, Marc U. Baumann
Summary: This study reveals the efficient role of the placental uric acid transport system in maintaining uric acid homeostasis, with GLUT9 playing a crucial role in this process. Further investigation on the role of the placental uric acid transport system in preeclampsia is urgently needed.
Article
Pharmacology & Pharmacy
Eva Bakos, Orsolya Nemet, Nora Kucsma, Natalia Tokesi, Bruno Stieger, Elisabeth Rushing, Anna-Maria Tokes, Peter Kele, Gabor E. Tusnady, Csilla Ozvegy-Laczka
Summary: In this study, the cloning and functional characterization of a third isoform of OATP3A1, OATP3A1_V3, was described. OATP3A1_V3 showed widespread expression in human organs, with the highest expression in the brain and testis. Immunostaining and functional assays confirmed the expression of OATP3A1_V3 in the human choroid plexus, neurons, and both germ and Sertoli cells of the testis, and identified dehydroepiandrosterone sulfate as a novel OATP3A1 substrate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bruno Stieger
Summary: The liver plays vital roles in the body, including bile formation and detoxification. Bile salts, the main components of bile, are organic anions and can be cytotoxic at high concentrations. The liver's detoxification function exposes it to many harmful compounds, which can potentially damage the liver. Impaired bile formation can lead to the accumulation of bile salts in the liver and subsequently result in liver disease. Diagnosing liver diseases involves measuring liver function parameters. This overview focuses on the role of organic anion transporters in bile formation at the protein level under normal physiological conditions and in liver function tests used for diagnosing liver diseases in pathophysiological situations.
Article
Multidisciplinary Sciences
Anca-Denise Ciuta, Kamil Nosol, Julia Kowal, Somnath Mukherjee, Ana S. Ramirez, Bruno Stieger, Anthony A. Kossiakoff, Kaspar P. Locher
Summary: This study presents cryo-EM structures of human OATP1B1 and OATP1B3, providing insights into their drug binding and functional characteristics.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Philipp Grossenbacher, Maria C. Essers, Joel Moser, Simon A. Singer, Stephanie Haeusler, Bruno Stieger, Jean-Sebastien Rougier, Martin Lochner
Summary: Antibodies are widely used in biochemical research and have applications in protein detection, purification, and targeted chemotherapy. However, current protocols for synthesizing fluorescent antibodies have limitations such as non-selective conjugation, over-labeling, or modification of antigen binding sites. In this study, a new strategy was used to introduce bright fluorescent dyes into antibodies without affecting their functionality.
Letter
Cell Biology
Hongtao Liu, Rossitza N. Irobalieva, Rose Bang-Sorensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A. Kossiakoff, Kaspar P. Locher