期刊
JOURNAL OF HEPATOLOGY
卷 60, 期 6, 页码 1290-1303出版社
ELSEVIER
DOI: 10.1016/j.jhep.2014.02.006
关键词
Animal model; Biliary fibrosis; Bile acids; Cholangiopathies; Cholestatic liver disease; Primary sclerosing cholangitis
资金
- NIDDK NIH HHS [R01 DK096096, R01 DK079005, P30 DK034989] Funding Source: Medline
Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B. V. All rights reserved.
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