期刊
JOURNAL OF HEPATOLOGY
卷 61, 期 4, 页码 925-943出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2014.05.046
关键词
Hepatocyte; Proliferation; Senescence; Immortalization
资金
- University Hospital of Vrije Universiteit Brussel (Willy Gepts Fonds UZ-VUB)
- Fund for Scientific Research Flanders (FWO-Vlaanderen)
- European Union
- European Research Council (ERC)
The liver has the unique capacity to regenerate in response to a damaging event. Liver regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell cycling. The hepatocyte cell cycle is a complex process that is tightly regulated by several well-established mechanisms. In vitro, isolated hepatocytes do not longer retain this proliferative capacity. However, in vitro cell growth can be boosted by immortalization of hepatocytes. Well-defined immortalization genes can be artificially overexpressed in hepatocytes or the cells can be conditionally immortalized leading to controlled cell proliferation. This paper discusses the current immortalization techniques and provides a state-of-the-art overview of the actually available immortalized hepatocyte-derived cell lines and their applications. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据