Article
Genetics & Heredity
Xin-Yi Liang, Yue Zhang, Ya-Nan He, Xue-Yi Liu, Zhi-Hao Ding, Xiao-Dong Zhang, Ming-You Dong, Run-Lei Du
Summary: This study explores the predictive value of hepatocellular carcinoma (HCC)-related genes and establishes a prediction model based on the TCGA database. The 3-gene signature constructed shows potential for predicting HCC prognosis, which is further validated using the ICGC dataset. Functional enrichment analysis and co-expression network analysis provide insights into the underlying mechanisms.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Duoduo Lv, Liyu Chen, Lingyao Du, Lingyun Zhou, Hong Tang
Summary: Hepatocellular carcinoma (HCC) is mainly driven by liver cancer stem cells (LCSCs), which contribute to tumor progression, metastasis, and treatment resistance. However, the regulatory mechanisms of LCSCs in HCC are still unclear. Understanding the signaling pathways responsible for LCSC maintenance and survival may improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qianhui Xu, Hao Xu, Shaohuai Chen, Wen Huang
Summary: This study revealed that liver cancer stem cells play a crucial role in clinical outcomes, tumor immune microenvironment complexity, and immunotherapeutic prediction at both mRNA level and stemness level. Quantitative identification of stemness characteristics in individual tumors can aid in predicting clinical outcomes, mapping the landscape of the tumor immune microenvironment, and optimizing precision immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qianhui Xu, Hao Xu, Shaohuai Chen, Wen Huang
Summary: This study comprehensively analyzed the stemness characteristics in HCC using RNA sequencing data and stemness indices, revealing a correlation between high stemness index and poor prognosis. A prognostic signature was established based on hub genes related to stemness, which successfully classified samples into risk subgroups with good prognostic performance. Additionally, the risk score derived from the signature was associated with the tumor immune microenvironment and immunotherapeutic targets, as well as tumor mutation burden.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Po-Da Chen, Ying-Yu Liao, Yu-Chia Cheng, Hsin-Yi Wu, Yao-Ming Wu, Min-Chuan Huang
Summary: The downregulation of B4GALT1 in hepatocellular carcinoma (HCC) is associated with vascular invasion and poor overall survival in patients. Silencing or loss of B4GALT1 enhances HCC cell migration and invasion, leading to lung metastasis. B4GALT1 alters N-glycosylation and enhances the laminin-binding activity of integrin alpha 6 and integrin beta 1, promoting invasiveness of HCC cells.
Article
Oncology
Han Chen, Kouki Nio, Taro Yamashita, Hikari Okada, Ru Li, Tsuyoshi Suda, Yingyi Li, Phuong Thi Bich Doan, Akihiro Seki, Hidetoshi Nakagawa, Tadashi Toyama, Takeshi Terashima, Noriho Iida, Tetsuro Shimakami, Hajime Takatori, Kazunori Kawaguchi, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Summary: The presence of cancer stem cells in hepatocellular carcinoma is closely related to bone morphogenic protein 9 (BMP9) signaling. High BMP9 expression leads to poorer outcomes in HCC patients, while BMP9 promotes CSC properties in a specific subtype of HCC. Inhibitors of BMP receptors have therapeutic potential in treating HCC by blocking BMP9 signaling and suppressing CSC activation.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Han Hong, Zhengkang Jin, Tao Qian, Xiaoyong Xu, Xiang Zhu, Qiang Fei, Jiamei Yang, Chengjun Sui, Minhui Xu
Summary: Falcarindiol (FAD) inhibits the proliferation and DNA repair of hepatocellular carcinoma (HCC) cells, promotes apoptosis, and enhances the chemosensitivity of cisplatin (DDP). FAD also exerts anti-tumor effects by dampening the STAT3/PTTG1 pathway in HCC cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Elena Porumb-Andrese, Mihaela Monica Scutariu, Ionut Luchian, Thomas Gabriel Schreiner, Ioana Martu, Vlad Porumb, Cosmin Gabriel Popa, Darius Sandu, Ramona Gabriela Ursu
Summary: Genetic mutations are linked to the occurrence of neoplasia, including skin cancer, but research on this association is limited and inconsistent. There are currently no established guidelines for molecular-level screening of skin cancer. Combinations of gene mutations may impact the biology and immune response of skin tumors, and this study focuses on the three major types of skin cancer.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell Biology
Umar Farooq, Hao Wang, Jingru Hu, Guangyue Li, Shah Jehan, Jinming Shi, Dangdang Li, Guangchao Sui
Summary: Polydatin (PD) is a natural compound that has anticancer activities, but its mechanisms of action are not well understood. PD selectively inhibited the proliferation of hepatocellular carcinoma (HCC) cells while showing low toxicity in normal cells. Additionally, PD enhanced the inhibitory effects of doxorubicin (DOX) and cisplatin (DDP) in HCC cells and reduced their toxicity in normal liver cells. RNA-seq studies revealed multiple altered signaling pathways in PD-treated HCC cells, and the expression of PD-repressed genes correlated with poor clinical outcomes in HCC patients. These findings improve our understanding of PD's anticancer mechanisms and suggest potential clinical approaches for HCC therapies.
Article
Medical Laboratory Technology
Joaquim S. L. Vong, Lu Ji, Macy M. S. Heung, Suk Hang Cheng, John Wong, Paul B. S. Lai, Vincent W. S. Wong, Stephen L. Chan, Henry L. Y. Chan, Peiyong Jiang, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo
Summary: This study utilized single-cell transcriptomic analysis and plasma RNA sequencing to identify the differences of CELSIG scores of hepatocyte-like cells in HCC patients, showing the potential application of this method in cancer detection.
CLINICAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Xiaomeng Dai, Yixuan Guo, Yan Hu, Xuanwen Bao, Xudong Zhu, Qihan Fu, Hangyu Zhang, Zhou Tong, Lulu Liu, Yi Zheng, Peng Zhao, Weijia Fang
Summary: The rapid development and remarkable success of checkpoint inhibitors in cancer treatment, including hepatocellular carcinoma, has provided significant breakthroughs. However, only a small percentage of patients benefit from these inhibitors, as cancer stem cells play a crucial role in recurrence, metastasis, and resistance to therapy. Understanding the mechanisms of immune evasion by CSCs in HCC is essential for developing effective therapies.
Article
Oncology
Muhammad G. Kibriya, Farzana Jasmine, Aaron Munoz, Tariqul Islam, Alauddin Ahmed, Lin Tong, Muhammad Rakibuz-Zaman, Mohammad Shahriar, Mohammed Kamal, Christopher R. Shea, Joseph H. Graziano, Maria Argos, Habibul Ahsan
Summary: This study is the first to examine the gene expression of basal cell carcinoma in the context of arsenic exposure. It found that high arsenic exposure is associated with impaired DNA replication, cellular response to DNA damage repair, and immune response. The study also suggests a lower chance of platinum drug resistance in basal cell carcinoma patients with high arsenic exposure.
Article
Multidisciplinary Sciences
Shanshan Wang, Jiarui Xie, Xuanxuan Zou, Taotao Pan, Qichao Yu, Zhenkun Zhuang, Yu Zhong, Xin Zhao, Zifei Wang, Rui Li, Ying Lei, Jianhua Yin, Yue Yuan, Xiaoyu Wei, Longqi Liu, Shiping Liu, Huanming Yang, Liang Wu
Summary: This study investigates the molecular mechanisms underlying metastasis in hepatocellular carcinoma (HCC) using single-cell transcriptomic, proteomic, and chromatin accessibility data. The researchers found that the prevalence of a mesenchymal state and levels of cell proliferation are linked to metastatic potential in HCC cell lines. They also identified a rare hypoxic subtype with increased glycolysis capacity and higher metastatic potential. Furthermore, they identified a 14-gene panel representing the hypoxia signature, which could serve as a prognostic index.
Article
Oncology
Daisuke Fukushi, Rie Shibuya-Takahashi, Mai Mochizuki, Haruna Fujimori, Takayuki Kogure, Takahiro Sugai, Wataru Iwai, Yuta Wakui, Makoto Abue, Kazuhiro Murakami, Yasuhiro Nakamura, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Chikashi Shibata, Yu Katayose, Kennichi Satoh, Keiichi Tamai
Summary: BEX2, highly expressed in hepatocellular carcinoma (HCC), is associated with poor prognosis and affects chemotherapy sensitivity in patients. Research shows that BEX2 induces CSC properties, including dormancy, impacting the progression of HCC.
Review
Oncology
Adriana G. Quiroz Reyes, Sonia A. Lozano Sepulveda, Natalia Martinez-Acuna, Jose F. Islas, Paulina Delgado Gonzalez, Tania Guadalupe Heredia Torres, Jorge Roacho Perez, Elsa N. Garza Trevino
Summary: Hepatocellular carcinoma (HCC) is a highly lethal and recurrent liver cancer, with death mainly caused by tumor progression, recurrence, metastasis, and chemoresistance. Cancer stem cells (CSCs) within the tumor promote invasion, recurrence, metastasis, and drug resistance. Hepatic stellate cells (HSCs) in the tumor microenvironment (TME) play important roles in fibrogenesis, tumor infiltration, and HCC development. Interactions between HSC and CSC, as well as their microenvironment, contribute to carcinogenesis through various mechanisms. This review summarizes the roles of CSCs and HSCs in establishing the TME in primary liver tumors and their involvement in HCC chemoresistance.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)