Review
Gastroenterology & Hepatology
Pinky Juneja, Dinesh M. Tripathi, Savneet Kaur
Summary: The gut lymphatic system plays a significant role in maintaining gut health, but it is one of the least studied physiological systems. The gut-liver axis is crucial in the pathogenesis of liver diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie J. Hectors, Octavia Bane, Paul Kennedy, Jordan Cuevas, Swan Thung, Aaron Fischman, Scott L. Friedman, Thomas D. Schiano, Bachir Taouli
Summary: The results of this study demonstrate the potential utility of hepatocyte uptake parameters and spleen interstitial fraction obtained with gadoxetate DCE-MRI for the diagnosis of portal hypertension and clinically significant portal hypertension. Liver uptake rate shows good diagnostic performance for the diagnosis of portal hypertension, while the combination of liver uptake rate with spleen interstitial fraction exhibits excellent diagnostic performance for the diagnosis of clinically significant portal hypertension.
EUROPEAN RADIOLOGY
(2021)
Article
Pathology
Lingtong Meng, Masanori Goto, Hiroki Tanaka, Yuki Kamikokura, Yumiko Fujii, Yoko Okada, Hiroyuki Furukawa, Yuji Nishikawa
Summary: The study demonstrates that decreased portal circulation, which induces hypoxia due to disrupted intralobular perfusion, is an important aggravating factor of liver fibrosis in NASH.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Medicine, General & Internal
Rakesh Kumar Jagdish, Akash Roy, Karan Kumar, Madhumita Premkumar, Mithun Sharma, Padaki Nagaraja Rao, Duvvur Nageshwar Reddy, Anand V. Kulkarni
Summary: Cirrhosis progresses from compensation to decompensation driven by the severity of portal hypertension, leading to various complications. The severity of portal hypertension also contributes to advanced complications such as hyperdynamic circulation and hepatorenal syndrome. The management of these complications has undergone significant developments. Acute-on-chronic failure (ACLF) is a rapidly worsening condition with high mortality, but early intervention can improve outcomes. This review focuses on complications of portal hypertension and approaches to managing ACLF.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov, Anna Kotlyarova
Summary: Atherosclerosis is a significant issue in modern medicine, with many aspects not fully understood by clinicians. It develops through a complex chain of events involving various cells of the vascular wall and peripheral blood flow. Endothelial cells, as the lining of blood vessels, have a crucial role in vascular biology, not only acting as a barrier between blood flow and tissues but also regulating hemodynamics and influencing other cells in the vascular wall. Kruppel-like factors (KLFs) have diverse biological functions in different cells of the vascular wall, particularly KLF2 and KLF4, which play important roles in both normal vascular function and atherosclerosis.
Article
Peripheral Vascular Disease
Yaxuan Ren, Jikang Shi, Sainan Liu, Wenfei Zhu, Aiyu Shao, Yichun Qiao, Yong Li, Yunkai Liu, Yi Cheng, Yawen Liu
Summary: miR-3656 impairs endothelial cell function in hypertension by inhibiting TFAP2C and disrupting the TFAP2C/KLF10 axis.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Adhara Lazaro, Patrick Stoll, Dominik von Elverfeldt, Wolfgang Kreisel, Peter Deibert
Summary: This study investigated the potential correlation between mean arterial pressure (MAP) and portal venous pressure (PVP) in rats with healthy livers. The results showed that changes in MAP are followed by changes in PVP with a distinct time lag, indicating a cause-and-effect relationship. The study also revealed that Sildenafil influences portal pressure. Further studies should be conducted in a model with cirrhotic livers to evaluate the effects of vasoactive drugs for therapy of portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Dominique Thabut, Masatoshi Kudo
Summary: Portal hypertension and hepatocellular carcinoma commonly coexist and their association affects the prognosis of cirrhosis patients. The interplay between these conditions has therapeutic significance in terms of treating HCC and managing PHT complications. The management recommendations for PHT have been revised, with new screening and prophylaxis indications. PHT may limit locoregional therapies and TIPS placement can be considered for HCC patients. New systemic HCC therapies can impact PHT levels and increase the risk of bleeding. Prevention and adequate treatment of PHT complications are important, particularly in advanced HCC cases. This expert opinion discusses specific aspects of managing both conditions, incorporating recent data in the HCC field.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fanny Turon, Ellen G. Driever, Anna Baiges, Eira Cerda, Angeles Garcia-Criado, Rosa Gilabert, Concepcio Bru, Annalisa Berzigotti, Isabel Nunez, Lara Orts, Juan Carlos Reverter, Marta Magaz, Genis Camprecios, Pol Olivas, Fabian Betancourt-Sanchez, Valeria Perez-Campuzano, Annabel Blasi, Susana Seijo, Enric Reverter, Jaume Bosch, Roger Borras, Virginia Hernandez-Gea, Ton Lisman, Juan Carlos Garcia-Pagan
Summary: In patients with cirrhosis, the main predictive factors for portal vein thrombosis (PVT) development are related to the severity of portal hypertension. There is no significant relationship between PVT development and other clinical, biochemical, inflammatory, and acquired or hereditary hemostatic parameters.
JOURNAL OF HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
E. Llop, J. L. Calleja
Summary: This article is linked to papers by Paternostro et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Hongqun Liu, Henry H. Nguyen, Sang Youn Hwang, Samuel S. Lee
Summary: Patients with portal hypertension may develop various complications, including cardiovascular abnormalities. Oxidative stress is believed to play a crucial role in the pathogenesis of these complications, and blocking oxidative stress could potentially alleviate the severity of cardiovascular diseases associated with portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Frank A. Simmen, Iad Alhallak, Rosalia C. M. Simmen
Summary: KLF9 and KLF13 are related proteins that play roles as regulators of specific target genes in various tissues and pathophysiological states, including cancer development. They have diverse functions in tumor suppression or promotion, differentiation, inflammatory pathways, oxidative stress, and tumor immune cell infiltration. The study of KLF9 and KLF13 in cancer biology is likely to provide valuable insights into oncogenesis and its prevention and treatments.
Article
Medicine, Research & Experimental
Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
Summary: The skeletal muscle Kruppel-like factor 15 (KLF15) plays a critical role in coordinating pathways central to systemic lipid homeostasis, regulating lipid uptake, mitochondrial transport, and utilization. Deletion of skeletal muscle-specific KLF15 leads to elevated circulating lipids, insulin resistance/glucose intolerance, and increased lipid deposition in white adipose tissue and liver, which can be ameliorated by a diet rich in short-chain fatty acids.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomoyuki Tsuzuki, Masatoshi Ishigami
Summary: Portal vein thrombosis (PVT) in patients with liver cirrhosis may improve spontaneously when large collateral vessels are absent. In these cases, observation without anticoagulation therapy can be considered in expectation of spontaneous reduction of PVT.
HEPATOLOGY RESEARCH
(2022)
Article
Medicine, General & Internal
Yiyan Zhang, Xintong Zhang, Xiangbo Xu, Xiaozhong Guo, Shixue Xu, Shaoze Ma, Jihong Chen, Xingshun Qi
Summary: This study evaluated the association of serum CLEC-2 and galectin-1 levels with PVST in HBV-related liver cirrhosis patients, finding that patients with PVST had significantly higher levels of CLEC-2 and galectin-1, and this association may depend on the degree of PVST.
FRONTIERS IN MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Jordi Gracia-Sancho, Jean-Francois Dufour
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Gastroenterology & Hepatology
Jiri Reinis, Oleksandr Petrenko, Benedikt Simbrunner, Benedikt S. Hofer, Filippo Schepis, Marco Scoppettuolo, Dario Saltini, Federica Indulti, Tomas Guasconi, Agustin Albillos, Luis Tellez, Candid Villanueva, Anna Brujats, Juan Carlos Garcia-Pagan, Valeria Perez-Campuzano, Virginia Hernandez-Gea, Pierre-Emmanuel Rautou, Lucile Moga, Thomas Vanwolleghem, Wihelmus J. Kwanten, Sven Francque, Jonel Trebicka, Wenyi Gu, Philip G. Ferstl, Lise Lotte Gluud, Flemming Bendtsen, Soren Moller, Stefan Kubicek, Mattias Mandorfer, Thomas Reiberger
Summary: Machine learning models based on standard laboratory parameters can predict the severity of portal hypertension in individuals with compensated advanced chronic liver disease (cACLD). The models performed well in the Vienna cohort but had heterogeneous results in external validation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Anna Baiges, Bogdan Procopet, Gilberto Silva-Junior, Elba Llop, Luis Tellez, Anna Darnell, Angeles Garcia-Criado, Fanny Turon, Oana Nicoara-Farcau, Carlos Gonzalez-Alayon, Helene Larrue, Marta Magaz, Pol Olivas, Valeria Perez-Campuzano, Jose Luis Calleja, Agustin Albillos, Juan Carlos Reverter, Christophe Bureau, Jaime Bosch, Virginia Hernandez-Gea, Juan Carlos Garcia-Pagan
Summary: The aim of this study was to describe the incidence of recurrent thrombosis (RT) in patients with non-cirrhotic splanchnic vein thrombosis (NC-SVT) and identify its risk factors. The study found that the risk of RT in NC-SVT patients without an indication for long-term anticoagulation is not low. Furthermore, factor VIII level may be a key indicator for predicting RT.
JOURNAL OF HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Dominique Thabut, Juan-Carlos Garcia-Pagan
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Anna Baiges, Joan Carles Reverter, Joan Carles Garcia Pagan
JOURNAL OF HEPATOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hector Ferral, Filippo Schepis, Ron C. Gaba, Guadalupe Garcia-Tsao, Alberto Zanetto, Valeria Perez-Campuzano, Ziv J. Haskal, Juan Carlos Garcia-Pagan
Summary: The hepatic venous pressure gradient (HVPG) is considered the gold standard for assessing portal hypertension in cirrhosis patients. Accurate and reproducible results are important for risk stratification, treatment allocation, follow-up monitoring, and surgical management decisions. The use of portosystemic pressure gradients in patients undergoing transjugular intrahepatic portosystemic shunts has been extensively studied and influences decisions regarding shunt diameter.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Savneet Kaur, Srivatsan Kidambi, Marti Ortega-Ribera, Le Thi Thanh Thuy, Natalia Nieto, Victoria C. Cogger, Wei-Fen Xie, Frank Tacke, Jordi Gracia-Sancho
Summary: In vitro models of liver, including cell lines, induced pluripotent stem cells, primary cells, and whole tissue slices, provide valuable tools for studying liver health, disease mechanisms, and therapeutic discovery. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned a working group to review and evaluate the advantages and disadvantages of these models for studying liver functionality, disease modeling, therapeutic discovery, and clinical applicability.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ian Rowe, Candid E. Villanueva, Jessica Shearer, Ferran Torres, Agustin Albillos, Joan C. Genesca, Joan Garcia-Pagan, Dhiraj C. Tripathi, Peter Hayes, Jaume G. Bosch, Juan Abraldes
Summary: This study conducted a Bayesian reanalysis of PREDESCI and found that beta-blocker treatment is highly likely to prevent decompensation and provides a substantial gain in decompensation-free life years at the population level.
Article
Gastroenterology & Hepatology
Angels Escorsell, Juan C. Garcia-Pagan, Edilmar Alvarado-Tapia, Carles Aracil, Helena Masnou, Candid Villanueva, Jaume Bosch
Summary: This study investigates the efficacy of pre-emptive TIPS (pTIPS) in patients with bleeding from gastric fundal varices. The results show that pTIPS can significantly improve the rebleeding-free survival in these patients compared to standard therapy. Therefore, the use of pTIPS should be considered in patients with Child-Pugh B or C scores bleeding from gastric fundal varices.
Article
Gastroenterology & Hepatology
Genis Camprecios, Aina Anton, Anna Oncins, Carla Montironi, Maria Ruart, Rosa Montanes, Hector Garcia-Caldero, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Liver sinusoidal endothelial cells (LSEC) are key elements in regulating the liver response to injury and regeneration. Endothelial autophagy plays a crucial role in protecting cells from injury-induced oxidative stress and fibrosis. However, this study found that endothelial autophagy is not essential for liver regeneration after partial hepatectomy (PHx).
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Eric Felli, Sonia Selicean, Sergi Guixe-Muntet, Cong Wang, Jaume Bosch, Annalisa Berzigotti, Jordi Gracia-Sancho
Summary: The interaction between mechanical stimuli and cellular mechanobiology plays a crucial role in the physiology of tissues and organs, particularly in cirrhosis. Various mechanical forces can trigger and sustain the progression of liver fibrosis, with reciprocal communication between cells and their environment driving disease progression. Therefore, mechanobiology-mediated pathways may serve as strategic targets for novel therapeutic approaches.
Letter
Hematology
Ellen G. Driever, Annabel Blasi, Juan-Carlos Garcia-Pagan, Ton Lisman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Delphine Weil Verhoeven, Dominique Thabut, Virginia Hernandez-Gea, Jean-Paul Cervoni, Bogdan Procopet, Arnaud Pauwels, Alvaro Giraldez, Lucio Amitrano, Nicolas Carbonell, Candido Villanueva Sanchez, Luis Ibanez Samaniego, Andre-Jean Remy, Gilberto Silva-Junior, Joan Genesca, Pierre Nahon, Jonel Trebicka, Xavier Causse, Rafael Banares, Aleksander Krag, Thierry Thevenot, Elba Llop Herrera, Wim Laleman, Jean-Francois Cadranel, Jose Maria Palazon Azorin, Jose Castellote Alonso, Isabelle Archambeaud Mabile, Susana Rodrigues, Lise Lotte Gluud, Slim Bramli, Carlos Noronha Ferreira, Nuria Canete, Florent Ehrhard, Manuel Rodriguez, Arnulf Ferlitsch, Philippe Ah-Soune, Remy Schwarzer, Florian Rostain, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Emile Alexandre Pariente, Romano Sassatelli, Alessandra Dell'Era, Julien Vergniol, Marco Senzolo, Juan G. Abraldes, Jean-Pierre Dupuychaffray, Manuel Romero-Gomez, Alexander Zipprich, Anne-Laure Pelletier, Meritxell Casas, Helena Masnou, Florence Skinazi, Massimo Primignani, Frederik Nevens, Anne Guillygomarc'h, Jose Luis Calleja, Christian Jansen, Rene-Louis Vitte, Marie-Angele Robic, Irene Conejo, Jean Henrion, Javier Martinez, Maria-Vega Catalina, Stephanie Combet, Agustin Albillos, Edilmar Alvarado-Tapias, Valeria Perez-Campuzano, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Helene Larrue, Marika Rudler, Ferran Torres, Georgina Casanovas, Christophe Bureau, Jaime Bosch, Juan Carlos Garcia-Pagan, Vincent Di Martino
Meeting Abstract
Gastroenterology & Hepatology
Delphine Weil Verhoeven, Dominique Thabut, Virginia Hernandez-Gea, Jean-Paul Cervoni, Bogdan Procopet, Arnaud Pauwels, Alvaro Giraldez, Lucio Amitrano, Nicolas Carbonell, Candido Villanueva Sanchez, Luis Ibanez Samaniego, Andre-Jean Remy, Gilberto Silva-Junior, Joan Genesca, Pierre Nahon, Jonel Trebicka, Xavier Causse, Rafael Banares, Aleksander Krag, Thierry Thevenot, Elba Llop Herrera, Wim Laleman, Jean-Francois Cadranel, Jose M. Palazon Azorin, Jose Castellote Alonso, Isabelle Archambeaud Mabile, Susana Rodrigues, Lise Lotte Gluud, Slim Bramli, Carlos Noronha Ferreira, Nuria Canete, Florent Ehrhard, Manuel Rodriguez, Arnulf Ferlitsch, Philippe Ah-Soune, Remy Schwarzer, Jose Luis Mundi, Florian Rostain, Henning Gronbaek, Manuel Hernandez-Guerra, Emile Alexandre Pariente, Romano Sassatelli, Alessandra Dell'Era, Julien Vergniol, Marco Senzolo, Juan G. Abraldes, Jean-Pierre Dupuychaffray, Manuel Romero-Gomez, Alexander Zipprich, Anne-Laure Pelletier, Meritxell Casas, Helena Masnou, Florence Skinazi, Massimo Primignani, Frederik Nevens, Anne Guillygomarc'h, Jose Luis Calleja, Christian Jansen, Rene-Louis Vitte, Marie-Angele Robic, Irene Conejo, Jean Henrion, Javier Martinez, Maria-Vega Catalina, Stephanie Combet, Agustin Albillos, Edilmar Alvarado Tapias, Valeria Perez-Campuzano, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Helene Larrue, Marika Rudler, Ferran Torres, Georgina Casanovas, Christophe Bureau, Jaime Bosch, Juan Carlos Garcia-Pagan, Vincent Di Martino
