期刊
ORAL DISEASES
卷 21, 期 8, 页码 987-993出版社
WILEY
DOI: 10.1111/odi.12374
关键词
MiRNA; oral lichen planus; saliva; exosome; biomarker
资金
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Korean Government (MSIP) [2008-0062282]
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2014R1A1A1003214]
- National Research Foundation of Korea [2008-0062282, 21A20132212438] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
ObjectiveOral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was designed to examine salivary exosomal microRNAs (miRNAs) that could be candidates for diagnosing and elucidating the pathogenesis of oral lichen planus. Subjects and MethodsWe compared miRNA profiles of salivary exosomes of patients with oral lichen planus with those of healthy controls. Saliva samples from 16 patients with oral lichen planus and eight healthy controls were divided into two sets and examined using miRNA microarray analysis and TaqMan quantitative PCR. ResultsThe three miRNAs identified (miR-4484, miR-1246, and miR-1290) were further validated. Of these, miR-4484 was significantly upregulated in the salivary exosomes of patients with oral lichen planus. ConclusionsThis study thus identifies a potential miRNA biomarker for oral lichen planus and provides insight into the functions of miRNAs in the pathogenesis of oral inflammatory diseases.
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