Article
Nutrition & Dietetics
Katarzyna Ilowiecka, Pawel Glibowski, Michal Skrzypek, Wojciech Styk
Summary: The study suggests that post-therapeutic support after weight loss can increase the chances of long-term weight maintenance in obesity treatment, and may be influenced by certain genotypes.
Article
Nutrition & Dietetics
Spyridon Tsirigkakis, George Mastorakos, Yiannis Koutedakis, Vassilis Mougios, Alan M. Nevill, Zoe Pafili, Gregory C. Bogdanis
Summary: A study comparing two high-intensity interval training protocols on obese men showed similar effects in improving regional body composition and fat oxidation. Both training programs effectively reduced trunk fat and increased leg lean mass, while enhancing fat oxidation during exercise. HIIT also resulted in improved peak fat oxidation, VO2peak, and decreased blood lactate levels at submaximal intensities.
Editorial Material
Biochemistry & Molecular Biology
R. James Stubbs
Summary: People on low-fat, low-energy-density diets tend to consume less energy ad libitum compared to those on high-fat, high-energy-density diets.
Article
Cardiac & Cardiovascular Systems
Christopher S. Digesu, Daniel Ospina-Delgado, Juan Ascanio, Adnan Majid, Mihir S. Parikh, Sidhu P. Gangadharan, Jennifer L. Wilson
Summary: Obese patients achieve similar improvement in HRQOL and functional capacity with comparable morbidity after TBP as nonobese patients. Obesity should not preclude patients with severe symptomatic excessive central airway collapse from TBP.
ANNALS OF THORACIC SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Xi Yang, Kaushik Chattopadhyay, Richard Hubbard, Jia-Lin Li, Li Li, Yi Lin
Summary: A 36-month weight management programme in Ningbo, China showed that participants achieved significant initial weight loss at 3 months and maintained the weight loss during 33-month follow-ups. At 36 months, a certain percentage of participants achieved 5%, 10%, and 15% weight loss. The programme is suggested to benefit overweight and obese adults in reducing body weight and maintaining long-term weight loss.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Joshua A. Levine, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan, Anne S. Henkel
Summary: Pharmacologic PAI-1 inhibition with TM5441 stimulates adipose tissue lipolysis and enhances weight loss in obese mice. The combination of TM5441 with dietary modification leads to greater weight loss and faster reversal of hepatic steatosis in obese mice compared to dietary modification alone. Increased expression of adipose triglyceride lipase, phosphorylated hormone-sensitive lipase, and phosphorylated perilipin-1 in adipose tissue was associated with enhanced weight loss in mice treated with TM5441.
Review
Obstetrics & Gynecology
Richard S. Legro
Summary: The associations between female obesity and adverse maternal and fetal outcomes have been extensively documented, including ovulatory dysfunction, delayed time to pregnancy, increased pregnancy loss, fetal anomalies, gestational diabetes, hypertensive disorders of pregnancy, preterm delivery, large for gestational age infants, and thromboembolic events. The role of preconception weight loss and its risk benefit ratio is uncertain, and the effects of obesity and preconception weight loss in males are less known.
FERTILITY AND STERILITY
(2022)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Samaneh Zolghadri, Armand Cholewka, Wojciech Myslinski
Summary: Obesity is a disease caused by the accumulation of fat, and dietary intervention is the primary treatment. Intermittent energy restriction diets have been proven effective for weight loss and have beneficial effects on metabolic parameters. This provides an alternative option for individuals who cannot adhere to continuous dietary restrictions.
Article
Sport Sciences
Jackson J. Peos, Eric R. Helms, Paul A. Fournier, Julian Ong, Carly Hall, James Krieger, Amanda Sainsbury
Summary: The study found that similar fat loss and fat-free mass retention were achieved with intermittent moderate energy restriction (mIER) and continuous moderate energy restriction (mCER) during 12 weeks of energy restriction, but mIER was associated with reduced appetite.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Review
Nutrition & Dietetics
Farah J. Alsharif, Yara A. Almuhtadi
Summary: With the global prevalence of obesity increasing dramatically, it has become a serious public health threat associated with comorbid conditions and psychological disorders. While lifestyle interventions and dietary adjustments may help with weight loss, maintaining these changes long-term can be challenging. Spices like turmeric, ginger, and pepper have shown promise in obesity management, with curcumin in particular gaining interest for its health benefits. Studies have shown potential favorable effects of curcumin supplementation on anthropometric indices, warranting further investigation for overweight or obese adults.
Article
Cell Biology
Panu K. Luukkonen, Kimmo Porthan, Noora Ahlholm, Fredrik Rosqvist, Sylvie Dufour, Xian-Man Zhang, Tiina E. Lehtimaki, Wenla Seppanen, Marju Orho-Melander, Leanne Hodson, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki-Jarvinen
Summary: The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but its underlying pathophysiology is still unclear. This study used state-of-the-art stable isotope techniques to investigate the effect of this variant on hepatic metabolism. The findings show that homozygous carriers of the PNPLA3 I148M variant have altered hepatic mitochondrial function, leading to reduced de novo lipogenesis and increased ketogenesis.
Review
Nutrition & Dietetics
Carlos Ruiz-Castellano, Sergio Espinar, Carlos Contreras, Fernando Mata, Alan A. Aragon, Jose Miguel Martinez-Sanz
Summary: This study focuses on the dietary-nutritional strategies for fat loss in resistance-trained athletes, emphasizing the goal of maximizing fat-free mass retention through proper caloric and protein intake. Additionally, carbohydrate intake and supplements such as caffeine and creatine monohydrate can also play a role in enhancing training performance in athletes.
Article
Endocrinology & Metabolism
Yonatan Lahav, Meital Adi, Eden Arberboy, Doron Halperin, Hagit Shoffel-Havakuk, Oded Cohen
Summary: The study found a positive correlation between BMI and laryngeal fat-pad volume in adult males, affecting morphology and airway width. Further investigation is needed regarding clinical implications for obstructive sleep apnea and voice quality.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Medicine, General & Internal
Yuping Liu, Ping Sun, Ping Shuai, Qichuan Qiao, Tingxin Li
Summary: Evidence on the benefits and risks of low-glycemic index and fat-restricted diets in weight loss and blood lipid profile changes remains unclear. A prospective pilot study in Southwest China found that a fat-restricted low-glycemic index diet could effectively control weight, reduce body fat percentage, and lower cholesterol and triglycerides levels in overweight/obese individuals, regardless of gender.
Letter
Acoustics
Angela Klain, Stefano Guarino, Anna Di Sessa, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
JOURNAL OF CLINICAL ULTRASOUND
(2022)
Article
Multidisciplinary Sciences
Paolo Montaldo, Simona Puzone, Elisabetta Caredda, Umberto Pugliese, Emanuela Inserra, Grazia Cirillo, Francesca Gicchino, Giuseppina Campana, Davide Ursi, Francesca Galdo, Margherita Internicola, Ferdinando Spagnuolo, Mauro Carpentieri, Carlo Capristo, Pierluigi Marzuillo, Emanuele Miraglia Del Giudice
Summary: Intrauterine growth restriction (IUGR) is associated with perinatal complications and long-term cardiovascular and renal diseases. This study investigates the effects of IUGR on renal and cerebral perfusion and oxygen saturation in term neonates. The results show that IUGR infants have left ventricular dysfunction, higher cerebral and renal oxygen saturation, and subclinical renal damage.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Giulio Rivetti, Brenden E. Hursh, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Summary: Children with type 1 diabetes mellitus have an increased risk of kidney involvement, with some of the risk occurring at the beginning of the disease and the rest being related to poor glycemic control and the development of diabetic kidney disease.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Pierluigi Marzuillo, Gemma Carreras-Badosa, Jose-Maria Martinez-Calcerrada, Stefano Guarino, Pier Luigi Palma, Delfina Petrone, Emanuele Miraglia del Giudice, Judit Bassols, Abel Lopez-Bermejo
Summary: This cross-sectional study evaluated the performance of height-, age-, and BSA-based kidney length percentiles in identifying small kidneys and predicting reduced eGFR and/or elevated BP in children with and without overweight/obesity. The results showed that BSA-based percentiles underestimate kidney length in overweight/obese children, and it is recommended to use height-based or ideal body surface area-based percentiles.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Pierluigi Marzuillo, Dario Iafusco, Stefano Guarino, Anna Di Sessa, Angela Zanfardino, Alessia Piscopo, Caterina Luongo, Daniela Capalbo, Martina Verde, Francesca Aiello, Adalgisa Festa, Emanuele Miraglia del Giudice, Anna Grandone
Summary: This study aimed to evaluate the association between euthyroid sick syndrome (ESS) and severity indexes of type 1 diabetes mellitus (T1DM) onset, such as diabetic ketoacidosis (DKA) and kidney damage. It also examined the relationship between clinical/metabolic parameters at T1DM onset and thyroid hormones, and the prognostic role of ESS in delayed recovery from kidney damage. The results showed that ESS was associated with severity of T1DM onset and delayed recovery from acute kidney injury.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Pier Luigi Palma, Anna Di Sessa, Antonio Paride Passaro, Eleonora Palladino, Giuseppe Furcolo, Annalisa Barlaba, Giulio Rivetti, Maeva De Lucia, Emanuele Miraglia del Giudice, Stefano Guarino, Pierluigi Marzuillo
Summary: The COVID-19 pandemic has led to changes in lifestyle for children with chronic kidney disease (CKD). A study found that the habits during the lockdown were associated with CKD progression, with less adherence to the Mediterranean diet and increased consumption of sweets and sugar-sweetened beverages playing a role.
Article
Endocrinology & Metabolism
A. Di Sessa, N. Cembalo Sambiase Sanseverino, R. F. De Simone, M. M. Marrapodi, G. Cirillo, G. R. Umano, S. Guarino, A. Papparella, E. Miraglia del Giudice, P. Marzuillo
Summary: The study aimed to evaluate the relationship between non-alcoholic fatty liver disease (NAFLD) and thyroid function tests, testing if the relationship could be driven by obesity and insulin resistance (IR), and to explore the influence of PNPLA3 I148M and TM6SF2 E167K polymorphisms on the association between NAFLD and thyroid function in children with obesity. The results showed that children with NAFLD had a higher prevalence of subclinical hypothyroidism (SH), and patients with SH had a higher risk of NAFLD. Severe obesity and IR degree were associated with both NAFLD and SH. The TM6SF2 E167K polymorphism was found to have a protective role against SH in children with obesity and NAFLD.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Maria Sole Valentino, Pierluigi Marzuillo, Claudia Esposito, Mario Bartiromo, Michele Nardolillo, Annalisa Valentina Villani, Alessandro Maresca, Giuseppe Furcolo, Stefano Guarino, Emanuele Miraglia del Giudice, Anna Di Sessa
Summary: It is found in the study that both direct and indirect effects of COVID-19 are present in all age groups. The impact of the COVID-19 pandemic lockdown on the relationship between MAFLD and renal function in children with CKD due to CAKUT was investigated. The study showed that CKD patients with MAFLD had higher levels of BMI-SDS, serum uric acid, triglycerides, and microalbuminuria, and lower eGFR levels. Patients with MAFLD also had higher ferritin and white blood cell concentrations compared to peers without MAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pierluigi Marzuillo, Pier Luigi Palma, Anna Di Sessa, Agnese Roberti, Giovanni Torino, Maeva De Lucia, Emanuele Miraglia del Giudice, Stefano Guarino, Giovanni Di Iorio
Summary: The aim of this study was to determine whether early measurements of serum aldosterone levels or plasmatic renin activity (PRA) could predict the need for surgical intervention in infants with obstructive congenital anomalies of kidney and urinary tract (CAKUT). A total of 20 infants aged 1-3 months with suspected obstructive CAKUT were prospectively enrolled and followed up for 2 years. The results showed that infants who required surgery had significantly higher levels of aldosterone at 1-3 months compared to those who did not require surgery (p = 0.006). The ROC curve analysis identified a cut-off of 100 ng/dL for aldosterone, which predicted the need for surgery with 100% sensitivity and 64.3% specificity. However, PRA measured at 1-3 months was not a predictor of surgery. In conclusion, early measurements of serum aldosterone levels can serve as a predictor for surgical intervention in infants with obstructive CAKUT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Pier Luigi Palma, Pierluigi Marzuillo, Anna Di Sessa, Stefano Guarino, Daniela Capalbo, Maria Maddalena Marrapodi, Giulia Buccella, Sabrina Cameli, Emanuele Miraglia del Giudice, Marco Torella, Nicola Colacurci, Carlo Capristo
Summary: Lower urinary tract symptoms (LUTS) are highly prevalent in the pediatric population, with diurnal incontinence and nocturnal enuresis being the most common symptoms. The presence of constipation should be considered and treated as it is often curative for both incontinence and enuresis. Diurnal symptoms in nocturnal enuresis and urgency in diurnal incontinence aid in the differential diagnosis. Urotherapy is the first-line treatment, with oxybutynin and desmopressin used if the initial treatment is unsuccessful. It is important to identify conditions that can be potentially harmful to the kidneys and urinary tract, as LUTS may be the initial manifestation.
Article
Endocrinology & Metabolism
Claudio La Scola, Giulio Rivetti, Cristina Bertulli, Anna Di Sessa, Stefano Guarino, Andrea Pasini, Pierluigi Marzuillo
Summary: The study found that children with tubulopathies may have an increased risk of overweight and obesity due to failure to thrive.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Genetics & Heredity
Giuseppina Rosaria Umano, Grazia Cirillo, Giulia Rondinelli, Gianmaria Sanchez, Pierluigi Marzuillo, Stefano Guarino, Anna Di Sessa, Alfonso Papparella, Emanuele Miraglia del Giudice
Summary: This study aimed to investigate the effect of LSS rs2254524 polymorphism on blood pressure in obese children and adolescents. The study found that individuals carrying the A allele had a higher risk of developing stage I and stage II hypertension. This risk was independent of confounding factors. Therefore, LSS rs2254524 worsens cardiovascular health in obese children and adolescents by increasing blood pressure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierluigi Marzuillo, Maria Paola Belfiore, Anna Di Sessa, Giovanni Torino, Agnese Roberti, Marialuisa Balzano, Alfonso Reginelli, Salvatore Cappabianca, Emanuele Miraglia del Giudice, Angela La Manna, Stefano Guarino, Giovanni Di Iorio
Summary: The study aimed to evaluate the diagnostic performance of clinical and radiological signs (on voiding cystourethrography [VCUG]) to detect posterior urethral valves (PUV) in the post-neonatal period. 118 male patients were prospectively enrolled and direct and indirect PUV signs on VCUG were assessed. Only half of patients with endoscopy-confirmed PUV presents with direct sign of PUV on VCUG.
EUROPEAN RADIOLOGY
(2023)
Article
Pediatrics
Maria Francesca Gicchino, Pierluigi Marzuillo, Rosa Melone, Sarah Zarrilli, Emanuele Miraglia del Giudice, Alma Nunzia Olivieri, Anna Di Sessa
Summary: In addition to obesity, being underweight may also have a negative impact on the severity of Juvenile Idiopathic Arthritis (JIA) in children. Patients with underweight and severe obesity have worse disease outcomes in JIA, highlighting the importance of weight control in managing the disease.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Maria Francesca Gicchino, Pierluigi Marzuillo, Sarah Zarrilli, Rosa Melone, Stefano Guarino, Emanuele Miraglia Del Giudice, Alma Nunzia Olivieri, Anna Di Sessa
Summary: Juvenile idiopathic arthritis (JIA) has been associated with metabolic impairments, and uric acid (UA) may serve as a useful marker for cardiometabolic risk and disease severity in children with JIA.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
