Review
Gastroenterology & Hepatology
Lingxuan An, Ulrich Wirth, Dominik Koch, Malte Schirren, Moritz Drefs, Dionysios Koliogiannis, Hanno Niess, Joachim Andrassy, Markus Guba, Alexandr Bazhin, Jens Werner, Florian Kuehn
Summary: Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty liver disease and alcoholic liver disease, strongly linked with obesity. Gut dysbiosis and gut barrier dysfunction crucially contribute to the development of chronic liver disease. Treatments targeting the gut microbiome and gut barrier have shown potential benefits in attenuating liver inflammation.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Nutrition & Dietetics
Namrata Iyer, Sinead C. Corr
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with a multifactorial etiology involving genetic, microbial, and environmental factors. The intestinal epithelium plays a central role in disease pathogenesis, while microbial metabolites are key regulators of gut homeostasis and the pathogenesis of IBD.
Article
Environmental Sciences
Yunhuan Liu, Weili Kang, Shuiping Liu, Jinyan Li, Jinyan Liu, Xingxiang Chen, Fang Gan, Kehe Huang
Summary: This study reveals a new mechanism of Cd-induced liver injury, in which Cd exposure leads to dysbiosis of gut microbiota, reduces fecal bile salt hydrolase activity, and increases the level of a certain substance in the intestine, thereby inhibiting intestinal FXR/FGF-15 signaling, increasing hepatic bile acid synthesis, and ultimately facilitating hepatic ductular proliferation, inflammation, and injury in mice.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Editorial Material
Cell Biology
Matthew Dodson, Donna D. Zhang
Summary: A recent study reveals that the formation of a complex named pyrimidinosome, consisting of enzymes involved in de novo pyrimidine synthesis and ferroptosis, is controlled by AMPK. Cancer cells with low AMPK expression rely on pyrimidinosome, suggesting that co-inhibition of AMPK and pyrimidinosome might be a potential strategy for cancer treatment.
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Takashi Nakanishi, Hirokazu Fukui, Xuan Wang, Shin Nishiumi, Haruka Yokota, Yutaka Makizaki, Yoshiki Tanaka, Hiroshi Ohno, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa
Summary: High-fat diet-induced dysbiosis in the small intestine leads to pathological changes in the luminal environment, disruption of small-intestinal mucosal integrity, and minimal inflammation in the gut-liver axis, ultimately resulting in the development of steatohepatitis in mice.
Article
Chemistry, Medicinal
Amit Kumar Ram, Balasubramaniyan Vairappan, Bheemanathi Hanuman Srinivas
Summary: This study found that nimbolide improves gut microbiota imbalance and bacterial translocation by modulating intestinal tight junction proteins, thereby preventing the progression of hepatocellular carcinoma (HCC). The findings suggest that nimbolide could be a novel therapeutic drug for HCC treatment by targeting the gut-liver axis.
PHYTOTHERAPY RESEARCH
(2022)
Editorial Material
Cell Biology
Li Jiang, Xiao-Meng Gao, Ji Cao
Summary: Resistance to programmed cell death called ferroptosis is linked to the development of certain difficult-to-treat cancers. Yang et al. provide a comprehensive understanding of the heterogeneity of ferroptosis in triple-negative breast cancers (TNBCs) and propose an innovative immunotherapy combination strategy for the luminal androgen receptor (LAR) subtype of TNBC.
Editorial Material
Microbiology
Carol A. Kumamoto, Jesus A. Romo
Summary: The study reveals that Debaryomyces hansenii fungus contributes to delayed wound healing in mice and is enriched in inflamed tissue from Crohn's disease patients, emphasizing the importance of further investigating fungal-host interactions.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Article
Business
Eirik Sjaholm Knudsen, Ivan Belik
Summary: Digital technologies have enhanced firms' ability to gain and maintain competitive advantages through network effects and large user bases. However, the seemingly stable advantage of large-scale user networks can quickly decline if influential users depart, especially for networks with small-world and scale-free properties. Through an analytical approach inspired by computational networks literature, we examine the impact of different network characteristics on the risk of rapid collapse and provide insights into the vulnerabilities of interconnected user networks.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Food Science & Technology
Yi Yang, Zhilei Zhou, Yufei Liu, Xibiao Xu, Yuezheng Xu, Weibiao Zhou, Shuguang Chen, Jian Mao
Summary: The consumption of fermented wine, Huangjiu, can alleviate the progression of alcoholic liver disease by regulating the intestinal barrier function and gut microbiota.
Review
Biochemical Research Methods
Suruchi Aggarwal, Anurag Raj, Dhirendra Kumar, Debasis Dash, Amit Kumar Yadav
Summary: Proteogenomics integrates genome and proteome analysis to improve genome annotation and discover new insights by controlling error rates. However, challenges arise due to database size inflation, leading to reduced sensitivity and specificity in proteogenomic studies. Understanding key factors and applying modified strategies can enhance interpretation of mass spectrometry data and effectively manage false positives and negatives.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Food Science & Technology
Erasme Mutuyemungu, Mukti Singh, Sean Liu, Devin J. Rose
Summary: In addition to causing embarrassment, intestinal gas can be associated with more serious symptoms. This review provides an overview of gas production by the human gut microbiome and outlines foods associated with intestinal gas. Foods rich in non-digestible carbohydrates such as pulses, vegetables, fruits, grains, and, for sensitive individuals, dairy, are fermented by colonic bacteria and produce gases directly or by cross-feeding, contributing to intestinal gas.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Studies
Brock Bergseth, Jon C. Day
Summary: Recent trends in rapidly establishing large protected areas indicate global interest in protecting natural environments. However, the effectiveness of these efforts is uncertain due to past implementation failures. Non-compliance in protected areas remains a significant issue, highlighting the need for a systematic approach to compliance management. We are collaborating with compliance experts to develop a framework and approach to address this problem and foster a global community.
Article
Surgery
Molly Kobritz, Colleen Nofi, Maria Sfakianos, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151 has the potential to therapeutically reduce acute intestinal injury in sepsis.