Article
Clinical Neurology
Gianvincenzo Sparacia, Giuseppe Parla, Roberto Cannella, Giuseppe Mamone, Ioannis Petridis, Luigi Maruzzelli, Vincenzina Lo Re, Mona Shahriari, Alberto Iaia, Albert Comelli, Roberto Miraglia, Angelo Luca
Summary: The study aimed to evaluate the performance of MRI-based radiomic features for diagnosing and grading chronic HE in adult patients affected by cirrhosis. The results showed that radiomic features were effective in predicting the presence of chronic HE and grading its severity.
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Xinyue Zhang, Jun Zhou, Mengyuan Guo, Shirui Cheng, Yilin Chen, Nannan Jiang, Xinling Li, Shengjie Hu, Zilei Tian, Zhengjie Li, Fang Zeng
Summary: This study comprehensively summarizes and meta-analyzes voxel-based morphometric neuroimaging studies of migraine. The findings reveal gray matter alterations in multiple brain regions in migraine patients, which may be a consequence of repeated migraine attacks.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Feifei Zhang, Song Wang, Yang Feng, Kun Qin, Huiru Li, Baolin Wu, Zhiyun Jia, Qiyong Gong
Summary: The study highlights the potential risk of exercise dependence (EXD) due to excessive exercise and the role of stress in its onset and development. The findings suggest that gray matter volume (GMV) in specific brain regions may mediate the relationship between stress and EXD, even after controlling for various factors such as sex, age, and psychological conditions.
HUMAN BRAIN MAPPING
(2021)
Article
Medicine, General & Internal
Piotr F. Czempik, Michal P. Pluta, Mariusz Hofman, Piotr S. Liberski, Tomasz Jaworski, Anna Szczepanska, Oskar Bozek
Summary: A 54-year-old male with impaired consciousness was admitted to the ICU. His medical history included alcohol dependence, liver cirrhosis, esophageal varices, previous banding procedures, and obesity. Imaging tests initially showed no abnormalities, but an urgent esophagogastroduodenoscopy revealed esophageal varices and scarification. Further investigations including neurologic assessment and MRI led to a diagnosis of hepatic encephalopathy. CT of the abdomen confirmed the diagnosis by showing intussusception of the ileum.
Article
Neuroimaging
Xiaoxi Ji, Hui Wang, Minwei Zhu, Yingjie He, Hong Zhang, Xiaoguang Chen, Wenpeng Gao, Yili Fu
Summary: The study revealed bilateral loss in the pons and left part of the midbrain in patients with mild Alzheimer's disease (AD-M) compared to the normal control group. There was also greater loss in the left midbrain in the AD-M group compared to those with very mild AD (AD-VM). This is the first VBM study providing evidence of early brainstem alterations in Alzheimer's disease.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Clinical Neurology
Alessandro Miola, Nicola Meda, Giulia Perini, Fabio Sambataro
Summary: Around one-third of patients with major depressive disorder do not see significant improvement in their symptoms even after adequate treatment with two different antidepressant medications. This condition, known as treatment-resistant depression (TRD), severely impacts the quality of life of millions of people worldwide, leading to long-lasting interpersonal problems and social costs. A systematic review of neuroimaging studies indicates that frontal, cerebellar, and brainstem functions may be involved in the pathophysiology of TRD, although the heterogeneity and limitations of the available literature restrict the generalizability of the findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Hernan C. Kulsgaard, Jose I. Orlando, Mariana Bendersky, Juan P. Princich, Luis S. R. Manzanera, Alberto Vargas, Silvia Kochen, Ignacio Larrabide
Summary: The study proposed to refine the findings of single subject VBM using SVM technique, which successfully reduced the false positive detections while maintaining the true positive findings. This method has the potential to assist radiologists and clinicians in manual analysis and increase the usability of SS-VBM for image reading.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Computer Science, Interdisciplinary Applications
Gabriel Solana-Lavalle, Roberto Rosas-Romero
Summary: This study proposes a new method for classifying 3-D MRI scans as an assisting tool for Parkinson's disease diagnosis, using separate experiments for men and women due to gender differences in disease prevalence. High detection performance was achieved, with men showing 99.01% accuracy and women showing 96.97% accuracy in classification experiments, highlighting the effectiveness of the proposed approach.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Review
Neurosciences
Licheng Zhu, Weihua Zhang, Lei Chen, Yanqiao Ren, Yanyan Cao, Tao Sun, Bo Sun, Jia Liu, Jing Wang, Chuansheng Zheng
Summary: This meta-analysis of voxel-based morphometry (VBM) studies reveals gray matter alterations in patients with hepatic encephalopathy (HE). The results suggest that gray matter volume in HE patients varies significantly and may be influenced by plasma ammonia. These findings contribute to a better understanding of the pathophysiology of cognitive dysfunction in HE patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Francina Hartmann, Julia Reinhardt, Christoph Stippich, Sabine Krumm
Summary: Voxel-based morphometry (VBM) is a method used to assess grey matter volumes in the brain, and the quality of MRI and data preprocessing steps can affect the results. This study found a lack of standardized protocols and that manual correction of voxel misclassification had minimal impact on Alzheimer's disease research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anatomy & Morphology
Stephanie Seidenbecher, Maria Schoene, Joern Kaufmann, Kolja Schiltz, Bernhard Bogerts, Thomas Frodl
Summary: The present study examined the structural brain characteristics in two healthy samples differing only in their propensity for aggressive behavior, revealing brain structural differences between the two groups in frontal and parietal brain areas critical for emotion processing/inhibition and empathy processes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Li, Tejasav S. Sehrawat, Jingbiao Chen, Moira B. Hilscher, Kevin J. Glaser, Juan P. Arab, Thiago Milech De Assuncao, Douglas A. Simonetto, Taofic Mounajjed, Armando Manduca, Richard L. Ehman, Vijay H. Shah, Meng Yin
Summary: The bi-parametric dual-frequency hepatic MRE model showed improved diagnostic accuracy for predicting portal hypertension in mouse models, especially in cases of hepatic congestion and cholestatic liver injury. This technical advancement has the potential to monitor PHTN progression and treatment efficacy in the presence of varying fibrosis.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Robert Grimm, Steven Sourbron, Hersh Chandarana, Yohan Son, Susmita Basak, Kyoung-Bun Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study demonstrates that liver MRI using GRASP technique can provide sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences in MRI-derived portal blood flow were found at different hepatic fibrosis stages.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Tripti Goel, Sirigineedi A. Varaprasad, M. Tanveer, Raveendra Pilli
Summary: This study aims to classify individuals with schizophrenia accurately using structural magnetic resonance imaging and to identify brain regions associated with the disorder. The findings suggest that deep learning can be a valuable tool for predicting, diagnosing, and treating schizophrenia.
Review
Gastroenterology & Hepatology
Gabriel Mezzano, Adria Juanola, Andres Cardenas, Esteban Mezey, James P. Hamilton, Elisa Pose, Isabel Graupera, Pere Gines, Elsa Sola, Ruben Hernaez
Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.
Article
Neurosciences
Enrico Premi, Tommaso Costa, Stefano Gazzina, Alberto Benussi, Franco Cauda, Roberto Gasparotti, Silvana Archetti, Antonella Alberici, John C. van Swieten, Raquel Sanchez-Valle, Fermin Moreno, Isabel Santana, Robert Laforce, Simon Ducharme, Caroline Graff, Daniela Galimberti, Mario Masellis, Carmela Tartaglia, James B. Rowe, Elizabeth Finger, Fabrizio Tagliavini, Alexandre de Mendonca, Rik Vandenberghe, Alexander Gerhard, Chris R. Butler, Adrian Danek, Matthis Synofzik, Johannes Levin, Markus Otto, Roberta Ghidoni, Giovanni Frisoni, Sandro Sorbi, Georgia Peakman, Emily Todd, Martina Bocchetta, Johnathan D. Rohrer, Barbara Borroni
Summary: The preGRN-MRI tool, based on baseline MRI measurements, can predict MRI atrophy at follow-up in presymptomatic FTD patients with good accuracy. It has potential applications in clinical trials.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Medicine, General & Internal
Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Jarvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Nuria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey Lazarus, Pere Gines, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns
Review
Gastroenterology & Hepatology
Jonel Trebicka, Alexandre Louvet, Vicente Arroyo, Rajiv Jalan, Vijay H. Shah, Richard Moreau
Summary: Alcoholic hepatitis is a severe form of alcoholic liver disease with rapid onset or worsening of jaundice. Diagnosis and treatment are challenging due to its complex pathogenesis. Current management is limited, and the use of liver transplantation and novel approaches is controversial.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Review
Gastroenterology & Hepatology
Paolo Caraceni, Alastair O'Brien, Pere Gines
Summary: Long-term administration of albumin may be effective and safe for treating patients with cirrhosis and ascites, but further research is needed to determine the target population, optimal dose and frequency of treatment, stopping rules, and cost-effectiveness in different healthcare systems.
JOURNAL OF HEPATOLOGY
(2022)
Article
Geriatrics & Gerontology
Lorenzo Pini, Francesca Benedetta Pizzini, Ilaria Boscolo-Galazzo, Clarissa Ferrari, Samantha Galluzzi, Maria Cotelli, Elena Gobbi, Annamaria Cattaneo, Maria Sofia Cotelli, Cristina Geroldi, Orazio Zanetti, Maurizio Corbetta, Martijn van den Heuvel, Giovanni Battista Frisoni, Rosa Manenti, Michela Pievani
Summary: The default mode and salience networks in Alzheimer's disease and behavioral variant of frontotemporal dementia exhibit different patterns of functional connectivity and modulatory effects. Anodal stimulation improves cognition, while cathodal stimulation improves behavior. Neither functional connectivity nor perfusion measurements show significant effects in both patient groups. The changes in functional connectivity between DMN and SN in AD are dependent on the stimulation protocol.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Domile Tautvydaite, Alexandra Adam-Darque, Paulina Andryszak, Lea Poitrine, Radek Ptak, Giovanni B. Frisoni, Armin Schnider
Summary: This study investigated the early electrophysiological correlates of novelty detection and encoding in patients with early Alzheimer's disease. The results showed that AD patients had difficulty in detecting novel stimuli and recognizing repeated ones, with abnormal weak early MTL activity compared to healthy controls.
Correction
Public, Environmental & Occupational Health
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Nuria Fabrellas, Llorenc Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Joern M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernandez, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adria Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Soenke Detlefsen, Pere Toran, Guillem Pera, Celine Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falco, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Gines
Review
Gastroenterology & Hepatology
Adria Juanola, Neha Tiwari, Cristina Sole, Danielle Adebayo, Florence Wong, Pere Gines
Summary: Acute-on-chronic liver failure (ACLF) is a complex syndrome associated with different organ failures in patients with chronic liver disease, mainly cirrhosis. Various definitions have been proposed, with differences in the severity of underlying liver disease, precipitating factors, and organs considered. Regardless of the definition, ACLF is characterized by hyperactive immune response, profound hemodynamic disturbances, and metabolic alterations leading to organ dysfunction. The triggers include bacterial infections, alcoholic hepatitis, gastrointestinal bleeding, and hepatitis B virus flare. Prompt recognition and treatment of the trigger event, as well as specific organ support, are crucial to improve short-term mortality. Liver transplantation may be considered in carefully selected patients.
LIVER INTERNATIONAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Adria Juanola, Ann T. Ma, Koos De Wit, Kohilan Gananandan, Olivier Roux, Giacomo Zaccherini, Cesar Jimenez, Marta Tonon, Cristina Sole, Clara Villaseca, Frank Erhard Uschner, Isabel Graupera, Elisa Pose, Elsa Sola, Ulrich Beuers, Rajeshwar P. Mookerjee, Claire Francoz, Victor Vargas, Salvatore Piano, Sonia Alonso, Jonel Trebicka, Wim Laleman, Sumeet K. Asrani, German Soriano Pastor, Miquel Serra-Burriel, Manuel Morales-Ruiz, Ferran Torres, Andrew S. Allegretti, Aleksander Krag, Paolo Caraceni, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Pere Gines, Ruben Hernaez
Article
Neuroimaging
Luigi Lorenzini, Silvia Ingala, Alle Meije Wink, Joost P. A. Kuijer, Viktor Wottschel, Mathijs Dijsselhof, Carole H. Sudre, Sven Haller, Juan Domingo Gispert, David M. Cash, David L. Thomas, Sjoerd B. Vos, Ferran Prados, Jan Petr, Robin Wolz, Alessandro Palombit, Adam J. Schwarz, Gael Chetelat, Pierre Payoux, Carol Di Perri, Joanna M. Wardlaw, Giovanni B. Frisoni, Christopher Foley, Nick C. Fox, Craig Ritchie, Cyril Pernet, Adam Waldman, Frederik Barkhof, Henk J. M. M. Mutsaerts
Summary: The European Prevention of Alzheimer Dementia (EPAD) study aims to characterize the early stages of Alzheimer's Disease using MRI data. This study presents a pipeline for curating, preprocessing, quality control, and computing image-derived phenotypes from the EPAD MRI dataset. The pipeline ensures standardized preprocessing and utilizes visual and quantitative assessments to evaluate image quality. The results demonstrate the potential of the dataset for future clinical analyses by showing associations with aging and dementia biomarkers.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marta Cervera, Marta Carol, Ana Belen Rubio, Martina Perez, Carlota Riba, Rosario Hernandez, Ann Ma, Emma Avitabile, Anna Soria, Octavi Bassegoda, Sara Martinez, Jordi Gratacos-Gines, Adria Juanola, Laura Napoleone, Elisa Pose, Isabel Graupera, Pere Gines, Nuria Fabrellas
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Maria Del Barrio Azaceta, Paula Iruzubieta, Rocio Aller de la Fuente, Jesus Maria Banales, Alvaro Santos-Laso, Jose Luis Calleja Panero, Luis Ibanez, Maria Teresa Arias Loste, Manuel Romero Gomez, Carmelo Garcia-Monzon, Judith Gomez-Camarero, Pere Gines, Rosa M. Morillas, Juan Manuel Pericas, Patricia Aspichueta, Rosa Martin-Mateos, Rocio Gallego-Duran, Mercedes De La Torre Sanchez, Desamparados Escudero-Garcia, Vanesa Bernal Monterde, Salvador Benlloch, Juan Turnes, Javier Crespo
JOURNAL OF HEPATOLOGY
(2022)