Review
Biochemistry & Molecular Biology
Licen Li, Chu-Xia Deng, Qiang Chen
Summary: SRC-3, also known as AIB1, is a member of the SRC family and plays a crucial role in regulating the transcriptional activity of nuclear receptors and promoting cancer development. Understanding the mode of action of SRC-3 can provide insights for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lu Xu, Zhe Huang, Tak-ho Lo, Jimmy Tsz Hang Lee, Ranyao Yang, Xingqun Yan, Dewei Ye, Aimin Xu, Chi-Ming Wong
Summary: The activation of the PRMT1/HNF-4α/PGC-1α signaling pathway may serve as a potential therapeutic strategy for combating non-alcoholic fatty liver disease in obese individuals.
Article
Medicine, Research & Experimental
Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Y. Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy Babwah, Moshmi Bhattacharya
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease associated with obesity, diabetes, and metabolic syndrome. Activation of the kisspeptin 1 receptor (KISS1R) signaling pathway has therapeutic effects in treating NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Plant Sciences
Yuanyuan Zhai, Wenling Zhou, Xu Yan, Yuan Qiao, Lingling Guan, Zhichun Zhang, Hao Liu, Jizhi Jiang, Jiang Liu, Liang Peng
Summary: This study investigated the effect of AS-IV on NAFLD and explored the involvement of intestinal flora. AS-IV treatment alleviated diet-induced metabolic impairments, particularly hepatic steatosis. The changes in intestinal flora and BAs were found to play an essential role in the remission of hepatic steatosis by AS-IV.
Article
Biochemistry & Molecular Biology
Xiaoqian Yu, Xiaoqi Bian, Hongmei Zhang, Shanshan Yang, Daxin Cui, Zhiguang Su
Summary: Liraglutide has been shown to improve hepatic steatosis in clinical practice, and this study reveals that the ameliorating effect may be dependent on the activity of RORa. Through experiments with mouse models and hepatocyte models, it was found that RORa plays a key role in the effect of liraglutide on hepatic lipid deposition.
Article
Gastroenterology & Hepatology
Yeeun Choi, Min-Ji Song, Woong-Jae Jung, Haengdueng Jeong, Seokjae Park, Bobae Yang, Eun-Chong Lee, Jung-Sik Joo, Dahee Choi, Seung-Hoi Koo, Eun-Kyoung Kim, Ki Taek Nam, Hyoung-Pyo Kim
Summary: This study demonstrated that liver-specific deletion of CTCF leads to hepatic steatosis and inflammation in mice, which is associated with increased nuclear accumulation of PPAR gamma and upregulation of downstream target genes such as CD36. Repression of PPAR gamma through pharmacologic blockade or adenovirus-mediated knockdown could ameliorate hepatic steatosis in CTCF-deficient mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xushan Yang, Linye Sun, Dongliang Feng, Yudi Deng, Wenzhen Liao
Summary: This study found that Nobiletin (NOB) can protect against hepatic steatosis and global lipid metabolism disorder. The lipidomic study revealed potential lipid markers of NOB treatment, particularly in glycerophospholipid metabolism. These findings provide new insights into the pathogenesis of hepatic steatosis and the antihepatic steatosis effect of NOB based on altering hepatic lipidome.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlene Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Helene Choubley, Loic Mazzeo, Louise Menegaut, Lorene Josiane Lebrun, Kevin Van Dongen, Marion Xolin, Tony Jourdan, Chloe Buch, Jerome Labbe, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober
Summary: Recent studies have found that LPCAT3 plays an important role in controlling the PUFA composition of cell membranes in the liver and intestine, but its role in macrophages remains controversial. Partial LPCAT3 deficiency in macrophages alters the PUFA composition of phospholipid subclasses and reduces cholesterol efflux, but does not impact inflammatory response or ER stress. Ultimately, myeloid LPCAT3 deficiency may affect AA homeostasis in the liver, leading to metabolic disorders and triglyceride accumulation.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sang Jun Han, Prashi Jain, Yosef Gilad, Yan Xia, Nuri Sung, Mi Jin Park, Adam M. Dean, Rainer B. Lanz, Jianming Xu, Clifford C. Dacso, David M. Lonard, Bert W. O'Malley
Summary: It was found that SRC-3 is highly expressed in regulatory T cells (Tregs) and B cells, indicating its important role in Treg function regulation. By using a genetically engineered tamoxifen-inducible Treg-cell-specific SRC-3 knockout (KO) mouse, it was observed that breast tumors and prostate cancer were permanently eradicated without autoimmune side effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Gastroenterology & Hepatology
Guannan Li, Hanqing Chen, Feng Shen, Steven Blake Smithson, Gavyn Lee Shealy, Qinggong Ping, Zerong Liang, Jingyan Han, Andrew C. Adams, Yu Li, Dechun Feng, Bin Gao, Masahiro Morita, Xianlin Han, Tim H. Huang, Nicolas Musi, Mengwei Zang
Summary: This study reveals the involvement of SRPK2 in the regulation of alternative splicing in lipogenesis in ALD patients. FGF21 alleviates ALD pathologies by inhibiting SRPK2. Targeting SRPK2 signaling by FGF21 may offer potential therapeutic approaches to combat ALD.
Article
Gastroenterology & Hepatology
Moris Sangineto, Christoph Grander, Felix Grabherr, Lisa Mayr, Barbara Enrich, Julian Schwarzler, Marcello Dallio, Vidyasagar Naik Bukke, Archana Moola, Antonio Moschetta, Timon E. Adolph, Carlo Sabba, Gaetano Serviddio, Herbert Tilg
Summary: Alcohol-related liver disease (ALD) is a major global burden. This study reveals the important role of Bacteroides thetaiotaomicron (Bt) in ethanol-induced liver steatosis and suggests Bt supplementation as a potential treatment for ALD, as it restores intestinal homeostasis and improves lipid metabolism.
Article
Gastroenterology & Hepatology
Feng Chen, Yingxia Liu, Qianhui Li, Fei Wang
Summary: This study found that there is a common activation of NLRP3 inflammasome between chronic hepatitis B (CHB) and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). Inhibiting NLRP3 inflammasome may be an effective strategy for the treatment of CHB and NASH.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zheng Zhang, Xiao Chen, Bo Cui
Summary: Manipulating the intestinal microbiome with resistant dextrin shows promise in ameliorating high-fat diet-induced hepatic steatosis, improving hepatic mitochondrial integrity, and reducing oxidative stress. Resistant dextrin alters the fecal microbial composition and metabolites, influencing pathways related to bile acids, tryptophan metabolism, and lipid metabolism, while also decreasing inflammatory cytokine levels and intestinal damage.
Article
Biochemistry & Molecular Biology
Yixiu Zhao, Na Sun, Xia Song, Jia Zhu, Tianshuo Wang, Zhiqi Wang, Yuanyuan Yu, Jing Ren, Huan Chen, Tingting Zhan, Jiaying Tian, Chunyue Ma, Jian Huang, Jinhui Wang, Yan Zhang, Baofeng Yang
Summary: This study has identified a novel anthraquinone compound called ESME that activates AdipoR2 to inhibit hepatic lipogenesis and promote fatty acid oxidation, thereby alleviating experimental hepatic steatosis. ESME has a strong binding potential with AdipoR2 and shows potent efficacy and safety in reducing hepatic steatosis and protecting hepatocytes. Oral administration of ESME reduces liver lipid production and accumulation in hamsters and Apoe-/-mice induced by high-fat diet.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Medicinal
Mingjie Sun, Yu Li, Songtao Su, Jiayi Gao, Lin Yu, Xinyi Qi, Huanjie Liang, Xiangling Li, Xinyu Qi, Yunxiao Liang, Lei Zhou, Guo Zhang, Yixing Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant health concern with limited effective treatment options. This study explored the potential of Tussilagone (TUS), a natural sesquiterpene, to treat NAFLD. In vitro and in vivo experiments demonstrated that TUS reduced lipid synthesis, improved glucose metabolism, increased energy metabolism, and decreased oxidative stress levels. TUS also showed promising results in reducing fat accumulation and improving liver injury in mice. These findings suggest that TUS may be a promising compound for the treatment of NAFLD by regulating lipid metabolism.
PHYTOTHERAPY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Bing Zhou, Caizhi Liu, Lingyan Xu, Youwen Yuan, Jiejie Zhao, Wenjun Zhao, Yiyan Chen, Jin Qiu, Meiyao Meng, Ying Zheng, Dongmei Wang, Xin Gao, Xiaoying Li, Qihong Zhao, Xiaohui Wei, Duojiao Wu, Huijie Zhang, Cheng Hu, Xiaozhen Zhuo, Minghua Zheng, Hua Wang, Yan Lu, Xinran Ma
Summary: In this study, it was found that m(6)A enrichment and mRNA expression of lipogenic genes were increased in leptin-receptor-deficient mice. The m(6)A reader, Ythdc2, was down-regulated in obese mice and NAFLD patients, and its suppression in lean mice led to TG accumulation while overexpression in obese mice improved liver steatosis and insulin resistance. This suggests that Ythdc2 plays a crucial role in regulating hepatic lipogenesis and TG homeostasis, presenting a potential target for treating obesity-related NAFLD.
Review
Endocrinology & Metabolism
Tianpei Hong, Qing Su, Xiaoying Li, Zhongyan Shan, Li Chen, Yongde Peng, Liming Chen, Li Yan, Yuqian Bao, Zhaohui Lyu, Lixin Shi, Weiqing Wang, Lixin Guo, Guang Ning, Yiming Mu, Dalong Zhu
Summary: It is important to assess and screen for cardiovascular risk factors, ASCVD and CKD in patients with T2DM. Metformin is recommended as a first-line therapy and additional medications like GLP-1RA or SGLT2 inhibitors may be considered for patients with established ASCVD, HF, or CKD. Comprehensive regimen including lifestyle intervention and management of multiple risk factors should be part of the treatment strategy for these patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Genetics & Heredity
Yakun Wang, Yinghui Qi, Tingting Ji, Bo Tang, Xiaoying Li, Pengxi Zheng, Shoujun Bai
Summary: In diabetic nephropathy, the expression level of circ_LARP4 is lower than in normal cells. Overexpression of circ_LARP4 can inhibit cell proliferation and fibrosis, but increase cell apoptosis, possibly through its sponge action on miR-424.
Review
Endocrinology & Metabolism
Fernando Gomez-Peralta, Ebaa Al-Ozairi, Edward B. Jude, Xiaoying Li, Julio Rosenstock
Summary: Despite numerous therapeutic options, many type 2 diabetes patients fail to achieve their HbA1c targets. This review examines the limitations of premix insulin injections and explores the potential benefits of fixed-ratio combinations (FRCs) of basal insulin and GLP-1 RAs as an alternative treatment option for intensification therapy. Results suggest that FRCs may offer improved HbA1c reductions, lower risk of hypoglycemia, and less weight gain compared to premix insulin in a simplified treatment regimen.
DIABETES OBESITY & METABOLISM
(2021)
Article
Immunology
Ling Wu, Yang Jiao, Yao Li, Jingjing Jiang, Lin Zhao, Menghui Li, Bin Li, Zheng Yan, Xuejin Chen, Xiaoying Li, Yan Lu
Summary: This study identified a pathway dependent on Gadd45 beta that stimulates hepatic glucose production, leading to hyperglycemia, while liver-specific Gadd45 beta-knockout mice showed resistance to high-fat diet or steroid-induced hyperglycemia. This suggests that Gadd45 beta promotes DNA demethylation, resulting in gluconeogenesis and hyperglycemia.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yang Liu, Xin Dou, Wei-Yu Zhou, Meng Ding, Ling Liu, Ruo-Qi Du, Liang Guo, Shu-Wen Qian, Yan Tang, Qi-Qi Yang, Dong-Ning Pan, Xiao-Ying Li, Yan Lu, Jin-Ke Cheng, Qi-Qun Tang
Summary: The liver-specific knockout of SENP2 in mice showed resistance to high-fat diet-induced hepatic steatosis and obesity, upregulation of genes involved in fatty acid oxidation, and downregulation of genes in lipogenesis. Additionally, ablation of hepatic SENP2 activated thermogenesis in adipose tissues, promoting energy homeostasis. FGF21 was identified as a key factor in maintaining metabolic balance in SENP2 knockout mice.
Article
Medicine, Research & Experimental
Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin, Pu Xia
Summary: Circulating levels of dhS1P and dhS1P/dhSph ratio are strongly associated with increased risk of T2DM, and could serve as a useful biomarker for predicting incident T2DM in normoglycemic populations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xiaowei Wang, Tingting Ji, Xiaoying Li, Xiaolei Qu, Shoujun Bai
Summary: The study reveals that FOXO3a protects against injury in type II diabetic nephropathy by increasing Sirt6 expression, which inhibits Smad3 transcriptional activity. This highlights the potential therapeutic strategy of targeting the FOXO3a-mediated Sirt6/Smad3 signaling pathways in treating type II diabetic nephropathy.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Yingchun Zhu, Fangfang Zha, Bo Tang, Ting-Ting Ji, Xiao-Ying Li, Linhong Feng, Shou-Jun Bai
Summary: The study found that high glucose-induced circ_0125310 promotes the progression of diabetic nephropathy by regulating miR-422a and the IGF1R/p38 axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Ting Hong, Yiyan Chen, Xiaoying Li, Yan Lu
Summary: The overproduction of ROS and oxidative stress play crucial roles in the pathogenesis of acute and chronic liver diseases. NAFLD is characterized as a redox-centered disease, and dysregulation of nuclear receptors (NRs) may be key in regulating this process. Targeting NRs could be a promising strategy for improving oxidation damage and treating NAFLD.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Multidisciplinary Sciences
Hua Zhang, Lin Zhao, Jingjing Jiang, Jie Zheng, Li Yang, Yanyan Li, Jian Zhou, Tianshu Liu, Jianmin Xu, Wenhui Lou, Weige Yang, Lijie Tan, Weiren Liu, Yiyi Yu, Meiling Ji, Yaolin Xu, Yan Lu, Xiaomu Li, Zhen Liu, Rong Tian, Cheng Hu, Shumang Zhang, Qinsheng Hu, Yangdong Deng, Hao Ying, Sheng Zhong, Xingdong Zhang, Yunbing Wang, Hua Wang, Jingwei Bai, Xiaoying Li, Xiangfeng Duan
Summary: As cancer is increasingly seen as a metabolic disorder, serum metabolite profiling is proposed as a viable method for detecting cancer. In this study, a machine learning model using mass spectrometry-based liquid biopsy data is reported for pan-cancer screening and classification. The Multiplexed Nanomaterial-Assisted LDI for Cancer Identification (MNALCI) achieves high sensitivity and specificity for distinguishing cancers from healthy controls and accurately identifying the tissue of origin of tumors. This high throughput assay shows promising potential for non-invasive cancer diagnosis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dalong Zhu, Xiaoying Li, Jianhua Ma, Jiao'e Zeng, Shenglian Gan, Xiaolin Dong, Jing Yang, Xiaohong Lin, Hanqing Cai, Weihong Song, Xuefeng Li, Keqin Zhang, Qiu Zhang, Yibing Lu, Ruifang Bu, Huige Shao, Guixia Wang, Guoyue Yuan, Xingwu Ran, Lin Liao, Wenjuan Zhao, Ping Li, Li Sun, Lixin Shi, Zhaoshun Jiang, Yaoming Xue, Hongwei Jiang, Quanmin Li, Zongbao Li, Maoxiong Fu, Zerong Liang, Lian Guo, Ming Liu, Chun Xu, Wenhui Li, Xuefeng Yu, Guijun Qin, Zhou Yang, Benli Su, Longyi Zeng, Houfa Geng, Yongquan Shi, Yu Zhao, Yi Zhang, Wenying Yang, Li Chen
Summary: Dorzagliatin is a drug that improves insulin secretion and glycemic control in drug-naive patients with type 2 diabetes, showing good efficacy and safety.
Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Article
Nutrition & Dietetics
Chunlan Zhang, Xi Chen, Shiping Liu, Wei Liu, Dalong Zhu, Xiaoying Li, Shen Qu, Zhiming Zhu, Jingjing Zhang, Zhiguang Zhou
Summary: Metabolic surgery has been shown to effectively treat obesity, but there is limited research on nutritional evaluations after surgery in Chinese patients. In this retrospective study, we found that Chinese patients undergoing metabolic surgery experienced changes in their nutritional status. Premenopausal females had a higher incidence of anemia at 12 months post-surgery, and preoperative anemia increased the risk of postoperative anemia. Ferritin levels decreased and iron deficiency increased among premenopausal females. However, there were no significant changes in folate deficiency and vitamin B12 deficiency throughout the study. Bone mineral density (BMD) significantly decreased from baseline to 12 months after surgery, but there were no new cases of osteopenia or osteoporosis. Nutrient supplements and long-term follow-up are necessary postoperation.
Article
Oncology
Xiaoyan Xiong, Bo Tang, Tingting Ji, Xiaoying Li, Shoujun Bai
Summary: miR-186 levels are significantly decreased in AKI patients and cells exposed to cisplatin, and overexpression of miR-186 can enhance cell proliferation and protect against cisplatin-induced apoptosis. ZEB1 has been identified as a target gene of miR-186, and its inhibition rescues cell proliferation and apoptosis. Therefore, miR-186 may serve as an effective biomarker for AKI by targeting ZEB1.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)