Review
Gastroenterology & Hepatology
Yuval Ishay, Yotam Kolben, Asa Kessler, Yaron Ilan
Summary: Hepatic encephalopathy is a common and debilitating complication of cirrhosis, affecting many patients despite the effectiveness of various therapies. The circadian rhythm plays a crucial role in liver functions, impacting liver pathology and metabolism. Utilizing circadian rhythm-based approaches could potentially enhance the efficacy of treatments for recurrent and persistent hepatic encephalopathy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Amira Moustafa
Summary: Chronic circadian disruption results in changes in immune functions, clock genes expression, and antioxidant enzyme levels, leading to hematological disruptions and inflammatory responses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Chuanqi He, Weiyi Shen, Chaobo Chen, Qihan Wang, Qifan Lu, Wentao Shao, Zhaoyan Jiang, Hai Hu
Summary: Disruption of circadian rhythm in mice leads to dysregulation of clock-related gene expression and disruption of the circadian rhythms of genes involved in bile acid and cholesterol metabolism. This is associated with high biliary cholesterol content and promotes gallstone formation in mice with disrupted circadian rhythm.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Vibha Narayanan, Andre L. Rodrigues, Jonathan S. Dordick
Summary: This study investigates the influence of a three-dimensional microenvironment on the rhythmic expression of genes in the liver. The cells were synchronized using serum shock and the expression of core clock regulators was assessed, demonstrating rhythmic expression of these genes. Statistical analysis revealed interrelations between various gene pairs. RNA sequencing provided in-depth understanding of the widespread effects of circadian regulation on genes involved in metabolic processes in the liver.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Gastroenterology & Hepatology
Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
Summary: Nonalcoholic fatty liver disease (NAFLD) is related to the disruption of the liver's biological clock, and nobiletin can improve NAFLD by restoring the biological clock. The study suggests that nobiletin reduces hepatic lipid accumulation and alleviates steatosis in obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Jia Luo, Zheng Yan, Manyun Dai, Liping Xu, Haoyue Zhang, Yang Xi, Julin Yang, Aiming Liu
Summary: This study aimed to investigate the role of PPAR alpha in modifying the circadian clock and its relevance to NAFLD. The authors used a mouse model and hepatocyte experiments to verify the effects of PPAR alpha on CLOCK regulation and lipid accumulation. They found that high-fat diet led to the down-regulation of CLOCK in the liver, and this down-regulation was dependent on PPAR alpha activity. Furthermore, they observed that down-regulation of hepatic CLOCK by basal PPAR alpha contributed to the inhibition of NAFLD development, while inhibition of CLOCK by activated PPAR alpha was involved in the inhibition of NAFLD by PPAR alpha agonists.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Environmental Sciences
Jinjin Jiang, Yaqin Gu, Shibin Ding, Guofu Zhang, Jinfeng Ding
Summary: Evidence shows that long-term ambient PM exposure disrupts the hepatic core circadian clock rhythm and disturbs glucose metabolism. The expression of BMAL1, Clock, and SIRT1 is significantly affected by ambient PM. However, this disruption can be restored by RES supplementation to improve glucose metabolism disorder.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Francesca Manocchio, Jorge R. Soliz-Rueda, Aleix Ribas-Latre, Francisca Isabel Bravo, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza
Summary: This study investigates the modulation of hepatic clock genes by grape seed proanthocyanidins extract (GSPE) through miRNAs. The results demonstrate that GSPE regulates the expression of Bmal1 and miR-27b-3p in the liver, and the modulation of peripheral clocks by GSPE via miRNA may involve a complex mechanism that interacts with the central system.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Physiology
Zhida Zhang, Le Cheng, Junxian Ma, Xiaomei Wang, Yingying Zhao
Summary: The circadian rhythm allows organisms to adapt to environmental changes through changes in physiology and behavior. This study explores the adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure. The findings suggest that chronic cold exposure does not alter the rhythmic expression of core clock genes in the liver, but rather rewires the expression of clock control genes to optimize liver metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ulrik Kraemer Sundekilde, Caroline Maag Kristensen, Mette Algot Olsen, Henriette Pilegaard, Martin Kroyer Rasmussen
Summary: The circadian rhythm has a significant impact on various physiological processes, including sleep-wake patterns, eating behavior, and hepatic detoxification. This study investigated the role of hepatic peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha) in the circadian regulation of cytochrome P450 enzymes (Cyps) in the liver. The results showed that the expression of circadian regulator genes Bmal1 and Clock was influenced by PGC-1 alpha, and the mRNA content of certain Cyps exhibited rhythmic expression. However, no significant circadian regulation was observed at the protein level. Principal component analysis further demonstrated the distinct differences between the control and PGC-1a LKO mice. These findings provide valuable insights into the molecular mechanisms underlying circadian regulation of Cyps and hepatic detoxification.
Article
Engineering, Marine
Wenwen Wang, Jing Hu, Zhengyi Fu, Gang Yu, Zhenhua Ma
Summary: This study demonstrates that the rhythm, lipid metabolism, and immune genes in the livers of mackerel tuna are influenced by time and weather, resulting in significant changes in gene expression.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher Amos, Yong Xu, Li Chen, Zheng Sun
Summary: The nuclear receptors REV-ERB-alpha and REV-ERB-beta in GABAergic neurons control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production, peaking at waking. This mechanism is crucial for understanding the extended dawn phenomenon in type 2 diabetes.
Article
Nutrition & Dietetics
Jorge Gutierrez-Hellin, Juan Del Coso, Millan Aguilar-Navarro, David Varillas-Delgado, Carlos Ruiz-Moreno, Alvaro Lopez-Samanes, Francisco J. Amaro-Gahete, Alejandro Munoz
Summary: This study aimed to evaluate the effect of p-synephrine on fat oxidation during exercise at different times of the day. The results showed that p-synephrine did not increase MFO and Fatmax, regardless of the time of day.
Article
Immunology
Jared Stern, Ajantha Solomon, Ashanti Dantanarayana, Rachel Pascoe, Arnold Reynaldi, Miles P. Davenport, Jeffrey Milush, Steven G. Deeks, Wendy Hartogensis, Frederick M. Hecht, Leslie Cockerham, Michael Roche, Sharon R. Lewin
Summary: This study found that cell-associated unspliced HIV RNA in people with HIV on antiretroviral therapy varies temporally with a circadian rhythm, while HIV DNA remains constant. Circulating estradiol is highly predictive of HIV RNA variation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Charlotte Andriessen, Daniel Doligkeit, Esther Moonen-Kornips, Marco Mensink, Matthijs K. C. Hesselink, Joris Hoeks, Patrick Schrauwen
Summary: The study found that energy expenditure has a day-night rhythm, while the day-night rhythm of carbohydrate and fat oxidation is mainly influenced by food intake. After an extended period of fasting, the absolute rate of fat oxidation rapidly increases, while carbohydrate oxidation gradually decreases.
CLINICAL NUTRITION
(2023)
Article
Oncology
Caroline Driescher, Katharina Fuchs, Lena Haeberle, Wolfgang Goering, Lisa Frohn, Friederike V. Opitz, Dieter Haeussinger, Wolfram Trudo Knoefel, Verena Keitel, Irene Esposito
Summary: This study demonstrated the feasibility and reliability of bile-derived cfDNA in the diagnosis of pancreatobiliary cancers, showing higher sensitivity compared to plasma and offering a potential alternative when tissue sampling is not feasible.
Article
Anesthesiology
Mark Michael, Noemi Freise, Verena Keitel, Andreas Schaper, Christian Plettenberg, Sven Dreyer, Michael Bernhard
Summary: Breathing lime is used in closed circuit and semi-closed circuit rebreathers for technical diving. Ingestion of components of the lime can lead to burns of the esophageal mucosa, requiring early endoscopy for assessment.
Article
Infectious Diseases
Lisa Muller, Philipp Niklas Ostermann, Andreas Walker, Tobias Wienemann, Alexander Mertens, Ortwin Adams, Marcel Andree, Sandra Hauka, Nadine Lubke, Verena Keitel, Ingo Drexler, Veronica Di Cristanziano, Derik Franz Hermsen, Rolf Kaiser, Friedrich Boege, Florian Klein, Heiner Schaal, Joerg Timm, Tina Senff
Summary: Evaluation and power of seroprevalence studies depend on the performed serological assays. This study compared four commercial serological tests and an in-house test for identifying SARS-CoV-2 seropositive individuals in a high-prevalence setting. Results showed that commercial assays detected antibodies in a higher percentage of individuals, and spike-based assays were better at predicting neutralization titer than nucleoprotein-based assays.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Obstetrics & Gynecology
Carsten Hagenbeck, Amr Hamza, Sven Kehl, Holger Maul, Frank Lammert, Verena Keitel, Matthias C. Hutten, Ulrich Pecks
Summary: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy, characterized by pruritus and elevated levels of bile acids and/or ALT. Maternal prognosis is good, while fetal outcome depends on bile acid levels and is associated with increased risks of preterm delivery and stillbirth.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Letter
Gastroenterology & Hepatology
Sven H. Loosen, Karel Kostev, Verena Keitel, Frank Tacke, Christoph Roderburg, Tom Luedde
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Sami-Alexander Safi, Lena Haeberle, Sophie Heuveldop, Patric Kroepil, Stephen Fung, Alexander Rehders, Verena Keitel, Tom Luedde, Guenter Fuerst, Irene Esposito, Farid Ziayee, Gerald Antoch, Wolfram Trudo Knoefel, Georg Fluegen
Summary: Preoperative CT scans can predict cancerous infiltration of the fat surrounding the pancreas, which can differentiate between patients receiving complete or incomplete resections. Identifying this infiltration can potentially lead to better treatment decisions and improved surgical outcomes.
Article
Public, Environmental & Occupational Health
Noemi F. Freise, Bjoern Jensen, Verena Keitel, Tom Luedde
Summary: Dengue virus infection causing gallbladder wall thickening is a differential diagnosis that should be considered in travelers returning from endemic areas, and should be managed conservatively due to the high risk of bleeding and mortality under surgical therapy.
TROPICAL DISEASES TRAVEL MEDICINE AND VACCINES
(2021)
Editorial Material
Gastroenterology & Hepatology
Javier Vaquero, Verena Keitel
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sven H. Loosen, Christoph Roderburg, Muenevver Demir, Natalia Qvartskhava, Verena Keitel, Karel Kostev, Tom Luedde
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Biochemical Research Methods
Alina Schrimpf, Olivia Knappe, Natalia Qvartskhava, Gereon Poschmann, Kai Stuehler, Hans Jurgen Bidmon, Tom Luedde, Dieter Haeussinger, Boris Goerg
Summary: This study investigates the molecular alterations in the brain associated with cerebral impairment in hyperammonemic disorders. Through transcriptomics and proteomics analysis, the researchers identified genes and proteins whose expressions were altered in a brain region-specific way in the brains of mice with systemic hyperammonemia. Further analyses of selected candidates revealed their roles in oxidative stress, cell proliferation, heme metabolism, senescence, RNA quality control, and disturbed iron homeostasis, suggesting their potential relevance in cerebral dysfunction in hyperammonemic disorders.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Dieter Haeussinger, Radha K. Dhiman, Vicente Felipo, Boris Gorg, Rajiv Jalan, Gerald Kircheis, Manuela Merli, Sara Montagnese, Manuel Romero-Gomez, Alfons Schnitzler, Simon D. Taylor-Robinson, Hendrik Vilstrup
Summary: Hepatic encephalopathy is a neuropsychiatric syndrome that occurs in patients with liver disease. It affects the quality of life of patients and is the most serious complication of decompensated liver cirrhosis. Ammonia and inflammation play key roles in the development of hepatic encephalopathy, leading to cerebral edema, oxidative/nitrosative stress, inflammation, and disturbances in brain networks. Lactulose and rifaximin are currently the main medical treatments.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Gastroenterology & Hepatology
Nils Bardeck, Martha Paluschinski, Mirco Castoldi, Claus Kordes, Boris Goerg, Jan Stindt, Tom Luedde, Stephan Vom Dahl, Dieter Haeussinger, David Schoeler
Summary: This study identified microRNA 141-3p as an osmosensitive miRNA that inhibits proliferation during liver cell swelling. Upregulation of microRNA 141-3p, controlled by Src-, Erk-, and p38-MAPK signaling, results in decreased mRNA levels of various genes involved in metabolic processes, macromolecular biosynthesis, and cell cycle progression.
Article
Gastroenterology & Hepatology
Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, Joerg Reinders, Stefan Hoehme, Abdel-latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher-Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez-Rodriguez, Ahmed Ghallab
Summary: The study revealed consistently regulated genes between mouse models and human chronic liver diseases, with the highest recall and precision observed in the 12-month CCl4-induced damage and Western diet model. Up-regulated genes in the chronic CCl4 model were enriched in inflammatory and developmental processes, predominantly mapping to specific liver cell types, while down-regulated genes were associated with metabolic processes in hepatocytes.
HEPATOLOGY COMMUNICATIONS
(2022)
Correction
Medicine, Research & Experimental
Johannes C. Fischer, Albrecht G. Schmidt, Edwin Bolke, Verena Keitel, Torsten Feldt, Bjorn Jensen, Noemi F. Freise, Dieter Haussinger, E. Marion Schneider, Derik Hermsen, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini, Jutta Rox, Vera Balz, Kitti Maas, Livia Schmidt, Olaf Grebe, Anja Ehrhardt, Peter Arne Gerber, Matthias Peiper, Bettina Alexandra Buhren, Artur Lichtenberg, Amir Rezazadeh, Wilfried Budach, Christiane Matuschek
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Johannes C. Fischer, Albrecht G. Schmidt, Edwin Boelke, Markus Uhrberg, Verena Keitel, Torsten Feldt, Bjoern Jensen, Dieter Haeussinger, Ortwin Adams, E. Marion Schneider, Vera Balz, Juergen Enczmann, Jutta Rox, Derik Hermsen, Karin Schulze-Bosse, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Martijn van Griensven, Jan Haussmann, Balint Tamaskovics, Christian Plettenberg, Kathrin Scheckenbach, Stefanie Corradini, Alessia Pedoto, Kitti Maas, Livia Schmidt, Olaf Grebe, Irene Esposito, Anja Ehrhardt, Matthias Peiper, Bettina Alexandra Buhren, Christian Calles, Andreas Stoehr, Artur Lichtenberg, Noemi F. Freise, Matthias Lutterbeck, Amir Rezazadeh, Wilfried Budach, Christiane Matuschek
Summary: The study found an association between certain HLA alleles and protective effects on disease duration in mild and moderate cases of COVID-19, while AB0 blood group antigens were linked to disease severity. There was a suggestive association between a heterozygous CCR5 delta 32 mutation status and prolonged disease duration, but further research is needed to confirm this.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
